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Das DRFZ – ein Vorreiter bei der Erforschung des Zusammenspiels von Immun- und Stromazellen bei der De- und Regeneration des Bewegungsapparats

The DRFZ—a pioneer in research on the interaction between immune and stromal cells during de- and regeneration of the musculoskeletal system

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Zusammenfassung

Rheumatoide Arthritis und Arthrose sind zwei verwandte chronische Erkrankungen des Bewegungsapparats mit besonderer Ausprägung im Bereich von Gelenken und Knochen, deren Pathogenese mit chronischen Entzündungsprozessen verbunden ist. Chronische Entzündungsprozesse können die Homöostase von Knochen und Gelenkknorpel aus dem Gleichgewicht bringen. So können Abbauprodukte des Gelenkknorpels zur Verstärkung der Entzündung im Gelenkbereich beitragen. Zudem spielen mechanische Stimuli und Blutgefäße eine zentrale Rolle sowohl in der Regulierung des Knochenwachstums als auch in der Regeneration von Knochengewebe. Nicht nur chronische Entzündungsprozesse, sondern auch hormonelle Veränderungen nach der Menopause oder die unerwünschten Nebenwirkungen einer Glukokortikoidtherapie beeinflussen den Knochenhaushalt, indem sie den Knochenabbau fördern und die Knochenbildung reduzieren. Dadurch entstehen Minderungen der Knochenqualität sowie ein teilweise erheblicher Knochenverlust bzw. eine Osteoporose. Ein tiefes Verständnis dieser Prozesse auf molekularer, zellulärer und Gewebeebene und ihrer Veränderungen in chronisch-entzündlichen Erkrankungen stehen schon seit der Gründung des Deutschen Rheuma-Forschungszentrums im Fokus der Forschung mit dem Ziel, bereits früh im Krankheitsverlauf eine Verbesserung der Präventions- und Therapiestrategien entwickeln zu können.

Abstract

Rheumatoid arthritis and osteoarthritis are two related chronic diseases of the musculoskeletal system which are particularly pronounced in the region of joints and bones. Their pathogeneses are associated with chronic inflammation, which can disrupt homeostasis in bones and articular cartilage. Degradation products deriving from articular cartilage can contribute to the exacerbation of inflammation in the joint region. Mechanical stimuli and blood vessels also play a central role in both the regulation of bone growth as well as in the regeneration of bone tissue. Not only chronic inflammatory processes but also hormonal changes after menopause or undesired effects of glucocorticoid therapy have an influence on the balance between bone resorption and deposition, by promoting the former and reducing the latter. This results in decreased bone quality and, in some cases, considerable loss of bone or osteoporosis. An in-depth understanding of these processes at the molecular, cellular, and tissue level, as well as of the changes present in chronic inflammatory diseases, has been the focus of research at the German Rheumatism Research Center (Deutsches Rheuma-Forschungszentrum, DRFZ) since its foundation. Based on an improved understanding of these mechanisms, the DRFZ aims to develop improved prevention and treatment strategies with effects even in early disease stages.

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Authors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum Berlin (DRFZ), Leibniz-Institut, Charitéplatz 1, 10117, Berlin, Deutschland

    Max Löhning, Ping Shen, Maria Dzamukova, Nayar Durán-Hernández, Jay Roodselaar, Anja E. Hauser, Alexander Fiedler & Raluca A. Niesner

  2. Medizinische Klinik mit Schwerpunkt Rheumatologie und Klinische Immunologie, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Deutschland

    Max Löhning, Ping Shen, Maria Dzamukova, Nayar Durán-Hernández, Jay Roodselaar, Anja E. Hauser, Timo Gaber & Frank Buttgereit

  3. Institut für Veterinär-Physiologie, Freie Universität Berlin, Berlin, Deutschland

    Alexander Fiedler & Raluca A. Niesner

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  1. Max Löhning
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  2. Ping Shen
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  10. Frank Buttgereit
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Correspondence to Max Löhning.

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M. Löhning, P. Shen, M. Dzamukova, N. Durán-Hernández, J. Roodselaar, A.E. Hauser, A. Fiedler, R.A. Niesner, T. Gaber und F. Buttgereit geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Löhning, M., Shen, P., Dzamukova, M. et al. Das DRFZ – ein Vorreiter bei der Erforschung des Zusammenspiels von Immun- und Stromazellen bei der De- und Regeneration des Bewegungsapparats. Z Rheumatol 81, 652–659 (2022). https://doi.org/10.1007/s00393-022-01188-3

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