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Wie T-Lymphozyten rheumatische Entzündung koordinieren

How T lymphocytes coordinate rheumatic inflammation

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Zusammenfassung

T‑Helfer(TH)-Lymphozyten spielen eine entscheidende Rolle bei der Auslösung und Aufrechterhaltung chronischer rheumatischer Entzündungen. Über die Ausschüttung von entzündungsfördernden Botenstoffen und die Expression kostimulatorischer Oberflächenmoleküle koordinieren sie die Rekrutierung und Aktivierung von Effektorzellen, die letztendlich die Immunpathologie und Gewebezerstörung auslösen. Allerdings waren Therapieansätze, die auf die Eliminierung von TH-Zellen abzielten, aufgrund ihrer mangelnden Selektivität nicht erfolgreich. Am Deutschen Rheuma-Forschungszentrum (DRFZ) wollen wir deshalb TH-Zellen , die an chronischen Entzündungsreaktionen beteiligt sind, besser verstehen. Unser Ziel ist es, basierend darauf neue therapeutische Strategien zu entwickeln, die pathogene TH-Zellen bei rheumatischen Entzündungen gezielt und selektiv bekämpfen. Die Erkenntnisse des DRFZ zu diesem Thema fasst der vorliegende Beitrag zusammen.

Abstract

Helper T (Th) cells play a decisive role in triggering and maintaining chronic rheumatic inflammation. Via secretion of proinflammatory cytokines and expression of costimulatory cell surface molecules, Th lymphocytes coordinate the recruitment and activation of effector cells, which are ultimately responsible for the immunopathology and tissue destruction. However, therapeutic approaches aimed at eliminating Th cells were unsuccessful due to their lack of selectivity. At the German Rheumatism Research Center (Deutsches Rheuma-Forschungszentrum, DRFZ), we are working to improve the understanding of the Th cells involved in chronic inflammatory reactions. Based on this understanding, our aim is to develop novel treatment strategies that selectively target the pathogenic Th lymphocytes causing rheumatic inflammation. The current article summarizes the DRFZʼs research activities on this subject.

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Authors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum Berlin, ein Institut der Leibniz Gemeinschaft, Charitéplatz 1, 10117, Berlin, Deutschland

    Hyun-Dong Chang, Andreas Radbruch, Tilmann Kallinich, Mir-Farzin Mashreghi, Ahmed N. Hegazy, Andrey Kruglov & Ria Baumgrass

  2. Institut für Biotechnologie, Technische Universität Berlin, Berlin, Deutschland

    Hyun-Dong Chang

  3. Klinik für Pädiatrie mit Schwerpunkt Pneumologie, Immunologie und Intensivmedizin, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Tilmann Kallinich

  4. Single Cell Laboratory for Advanced Cellular Therapies, Berlin Center for Regenerative Therapies (BCRT), Berlin Institute of Health, Berlin, Deutschland

    Mir-Farzin Mashreghi

  5. Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité – Universitätsmedizin Berlin, Berlin, Deutschland

    Ahmed N. Hegazy

  6. Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russland

    Sergei Nedospasov

  7. Sirius University of Science and Technology, Sochi, Russland

    Sergei Nedospasov

Authors
  1. Hyun-Dong Chang
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  2. Andreas Radbruch
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  3. Tilmann Kallinich
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  4. Mir-Farzin Mashreghi
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  5. Ahmed N. Hegazy
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  6. Andrey Kruglov
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  7. Sergei Nedospasov
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  8. Ria Baumgrass
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Corresponding author

Correspondence to Hyun-Dong Chang.

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Interessenkonflikt

H.-D. Chang, A. Radbruch, T. Kallinich, M.-F. Mashreghi, A.N. Hegazy, A. Kruglov, S. Nedospasov und R. Baumgrass geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Andreas Radbruch, Berlin

Reinhold E. Schmidt, Hannover

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Chang, HD., Radbruch, A., Kallinich, T. et al. Wie T-Lymphozyten rheumatische Entzündung koordinieren. Z Rheumatol 81, 635–641 (2022). https://doi.org/10.1007/s00393-022-01186-5

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  • DOI: https://doi.org/10.1007/s00393-022-01186-5

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