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Integrated comparison of the mRNAome in cartilage, synovium, and macrophages in osteoarthritis

Integrierter Vergleich des mRNAome in Knorpel, Synovium und Makrophagen bei Arthrose

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Abstract

The precise molecular mechanisms associated with osteoarthritis (OA), the most common musculoskeletal disorder, are poorly understood. There are currently no effective treatments to prevent the initiation and progression of the disease. In recent years, the development of mRNAome has made it possible to identify new mechanisms and therapeutic targets. However, the differentially expressed genes screened by different microarrays are not completely the same. In order to avoid this shortcoming, we integrate the different genes from different tissues and data sets, and select the commonly expressed genes for further studies.

Zusammenfassung

Bisher sind die genauen molekularen Mechanismen, die mit Arthrose, der häufigsten mukuloskeletalen Erkrankung, einhergehen, nur unzureichend verstanden. Derzeit stehen keine wirksamen Therapien zu Verfügung, um den Beginn und das Fortschreiten der Krankheit zu verhindern. In den letzten Jahren ist es durch die Entwicklung des mRNAoms möglich geworden, neue Mechanismen und therapeutische Ziele zu identifizieren. Aber die unterschiedlich exprimierten Gene, die mittels verschiedener Microarrays untersucht werden, sind nicht völlig identisch. Um diesem Mangel abzuhelfen, werden die unterschiedlichen Gene aus verschiedenen Geweben und Datensätzen integriert und die häufig exprimierten Gene für weitere Studien ausgewählt.

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Funding

This work was supported by grants from the National Natural Science Foundation of China (81901668) and Beijing Jishuitan Hospital Nova Program (XKXX-202112).

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  1. Department of Rheumatology, Beijing Jishuitan Hospital, No. 31, Xin Jie Kou East Street, Xicheng District, 100035, Beijing, China

    Siming Gao & Hui Song

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  1. Siming Gao
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  2. Hui Song
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Correspondence to Hui Song.

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S. Gao and H. Song declare that they have no competing interests.

For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case.

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Ulf Müller-Ladner, Bad Nauheim

Uwe Lange, Bad Nauheim

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Table S1

Differentially expressed mRNAs in osteoarthritis (upregulated)

Table S2

Differentially expressed mRNAs in osteoarthritis (downregulated)

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Gao, S., Song, H. Integrated comparison of the mRNAome in cartilage, synovium, and macrophages in osteoarthritis. Z Rheumatol 83 (Suppl 1), 62–70 (2024). https://doi.org/10.1007/s00393-022-01171-y

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