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Neue Substanzen zur Therapie der juvenilen idiopathischen Arthritis

New drugs for treatment of juvenile idiopathic arthritis

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Zusammenfassung

Die Einführung der Biologika vor 20 Jahren hat die Pharmakotherapie der juvenilen idiopathischen Arthritis wesentlich gewandelt. Biologika zählen zu den erfolgreichsten Innovationen nicht nur in der Rheumatologie und bieten neben einem raschen Wirkeintritt und einer starken Wirksamkeit auch eine Option zur Prävention von Langzeitschäden und die realistische Aussicht auf eine Remission. Auf Innovationen bei den Biologika und die Bedeutung der neuesten Gruppe zur „targeted therapy“ mit „small molecules“ in der Kinderrheumatologie wird in diesem Beitrag eingegangen.

Abstract

The introduction of biologics 20 years ago has significantly changed the pharmacotherapy of juvenile idiopathic arthritis. Biologics are among the most successful innovations, not only in rheumatology. In addition to their strong efficacy the rapid onset of improvement , biologics offer an option for prevention of long-term damage and a realistic prospect of remission. This article discusses innovations in biologics and the importance of the latest group for targeted therapy with small molecules in pediatric rheumatology.

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  1. Zentrum für Allgemein Pädiatrie und Neonatologie, Asklepios Klinik Sankt Augustin, 53757, Sankt Augustin, Deutschland

    Gerd Horneff

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G. Horneff weist auf folgende Beziehungen hin: Forschungsunterstützung: Abbvie, Chugai, MSD, Novartis, Pfizer, Roche; Honorare für Vortragstätigkeit/Advisory-Board-Teilnahme: Abbvie, Bayer, BMS, Chugai, Lilly, MSD, Novartis, Pfizer, Roche.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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H.-I. Huppertz, Bremen,

K. Minden, Berlin

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Horneff, G. Neue Substanzen zur Therapie der juvenilen idiopathischen Arthritis. Z Rheumatol 78, 587–598 (2019). https://doi.org/10.1007/s00393-019-0646-3

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