Association between anti-Porphyromonas gingivalis antibody, anti-citrullinated protein antibodies, and rheumatoid arthritis

A meta-analysis
Originalien
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Abstract

Objective

The aim of this study was to determine the relationship between anti-Porphyromonas gingivalis (anti-P. gingivalis) antibody levels and rheumatoid arthritis (RA) and its correlation with anti-citrullinated protein antibodies (ACPA).

Methods

We performed a meta-analysis of studies comparing (a) anti-P. gingivalis antibody levels in RA patients and healthy controls and (b) the correlation coefficients between the anti-P. gingivalis antibody levels and ACPA in RA patients.

Results

The study included 14 articles with 3829 RA patients and 1239 controls. Our meta-analysis showed that anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group (standardized mean difference [SMD] = 0.630, 95% CI = 0.272–0.989, p = 0.001). Subgroup analysis revealed that RA patients had significantly elevated anti-P. gingivalis antibody levels compared with healthy controls, but not compared with the non-RA control group and also not between different sample sizes. Anti-P. gingivalis antibody levels were significantly higher in the RA group than in the control group in the age-/sex-matched population, but not in the unmatched population. Anti-P. gingivalis antibody levels were significantly higher in the ACPA-positive group than in the ACPA-negative group (SMD = 0.322, 95% CI = 0.164–0.480, p = 6.4 × 10−5). Meta-analysis of the correlation coefficients showed a significant positive correlation between anti-P. gingivalis antibody levels and ACPA (correlation coefficient = 0.147, 95% CI = 0.033–0.258, p = 0.012).

Conclusion

Our meta-analysis demonstrated that anti-P. gingivalis antibody levels were significantly higher in patients with RA and they were positively correlated with ACPA.

Keywords

Anti-Pgingivalis antibody Anti-citrullinated protein antibodies Rheumatoid arthritis 

Zusammenhang zwischen Anti-Porphyromonas-gingivalis-Antikörpern, Anti-citrulliniertes-Protein-Antikörpern und rheumatoider Arthritis

Eine Metaanalyse

Zusammenfassung

Ziel

Ziel der Studie war es, die Assoziation vom Anti-Porphyromonas-gingivalis-Antikörper-Spiegeln (Anti-P.-gingivalis-AK) und rheumatoider Arthritis (RA) sowie deren Korrelation mit Anti-citrulliniertes-Protein-Antikörpern (ACPA) zu ermitteln.

Methoden

Es erfolgte eine Metaanalyse von Studien, die zum einen die Anti-P.-gingivalis-AK-Spiegel bei RA-Patienten und gesunden Kontrollen verglichen und zum anderen die Korrelationskoeffizienten zwischen Anti-P.-gingivalis-AK-Spiegeln und ACPA bei RA-Patienten untersuchten.

Ergebnisse

Die Studie umfasste 14 Beiträge mit 3829 RA-Patienten und 1239 Kontrollen. Die vorliegende Metaanalyse zeigte, dass die Anti-P.-gingivalis-AK-Spiegel in der RA-Gruppe signifikant höher waren als in der Kontrollgruppe (standardisierte Mittelwertdifferenz, SMD: 0,630; 95%-Konfidenzintervall, 95%-KI: 0,272–0,989; p = 0,001). Die Subgruppenanalyse ergab, dass RA-Patienten im Vergleich zu gesunden Kontrollen signifikant erhöhte Anti-P. gingivalis-AK-Spiegel aufwiesen, nicht aber gegenüber der Kontrollgruppe ohne RA und auch nicht im Vergleich zwischen verschiedenen Stichprobengrößen. Die Anti-P.-gingivalis-AK-Spiegel waren in der RA-Gruppe signifikant höher als in der Kontrollgruppe in der nach Alter und Geschlecht gematchten Population, nicht aber in der ungematchten Population. In der ACPA-positiven Gruppe waren die Anti-P.-gingivalis-AK-Spiegel signifikant höher als in der ACPA-negativen Gruppe (SMD: 0,322; 95%-KI: 0,164–0,480; p = 6,4 × 10−5). Die Metaanalyse der Korrelationskoeffizienten zeigte eine signifikante positive Korrelation zwischen den Anti-P.-gingivalis-AK-Spiegeln und ACPA (Korrelationskoeffizient: 0,147; 95% -KI: 0,033–0,258; p = 0,012).

Schlussfolgerung

Die vorliegende Metaanalyse zeigte, dass die Anti-P.-gingivalis-AK-Spiegel bei RA-Patienten signifikant höher und mit APCA positiv korreliert waren.

Schlüsselwörter

Anti-Porphyromonas-gingivalis-Antikörper Anti-citrulliniertes-Protein-Antikörper Rheumatoide Arthritis 

Notes

Funding

This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI15C2958).

Compliance with ethical guidelines

Conflict of interest

S.-C. Bae and Y.H. Lee declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Department of RheumatologyHanyang University Hospital for Rheumatic DiseasesSeoulKorea (Republic of)
  2. 2.Division of Rheumatology, Department of Internal Medicine, Korea University Anam HospitalKorea University College of MedicineSeoulKorea (Republic of)

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