Zeitschrift für Rheumatologie

, Volume 76, Issue 4, pp 372–374 | Cite as

Adalimumab-induced pulmonary sarcoidosis not progressing upon treatment with etanercept

  • J. H. Jung
  • J.-H. Kim
  • G. G. Song


Tumor necrosis factor alpha (TNF-α) inhibitors effectively treat sarcoidosis, but can, paradoxically, induce sarcoidosis. The TNF-α inhibitor etanercept is most commonly associated with paradoxical sarcoidosis, which has previously been reported to be resolved by adalimumab. However, we describe the case of a patient with ankylosing spondylitis and adalimumab-induced sarcoidosis not aggravated by switching to etanercept, thus indicating that etanercept could be a treatment option for patients who develop paradoxical sarcoid-like reactions after treatment with other TNF-α inhibitors.


Adalimumab Etanercept Pulmonary sarcoidosis Tumor necrosis factor-α Paradoxical response 

Kein Fortschreiten einer Adalimumab-induzierten Lungensarkoidose unter Etanercept


Tumor-Nekrose-Faktor-α(TNF-α)-Inhibitoren sind ein wirksames Therapeutikum der Sarkoidose, können aber paradoxerweise eine Sarkoidose auch induzieren. Der TNF-α-Inhibitor Etanercept ist am häufigsten mit einer paradoxen Sarkoidose assoziiert. Wie berichtet wurde, konnte diese mit Adalimumab kuriert werden. In dieser Kasuistik beschreiben wir jedoch den Fall eines Patienten mit ankylosierender Spondylitis und Adalimumab-induzierter Sarkoidose, die sich nach einem Wechsel zu Etanercept nicht verschlechterte. Daher könnte Etanercept eine Behandlungsoption für Patienten sein, bei denen es nach Therapie mit anderen TNF-α-Inhibitoren zu paradoxen sarkoidähnlichen Reaktionen kommt.


Adalimumab Etanercept Lungensarkoidose Tumor-Nekrose-Faktor-α Paradoxe Antwort 


Compliance with ethical guidelines

Conflict of interest

J. H. Jung, J.-H. Kim, and G. G. Song declare that they have no competing interests.

All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Korea University College of MedicineSeoulKorea
  2. 2.Division of Rheumatology, Department of Internal MedicineKorea University Guro HospitalSeoulKorea

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