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Knochen- und Fettgewebebildung

Bone and adipose tissue formation

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Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Leptin wird eine zentrale Rolle in der Knochenhomöostase zugeschrieben, sowohl durch systemische als auch durch lokale Wirkungen. Systemisch scheint Leptin die Knochenbildung zu inhibieren, kontrolliert durch eine Rückkopplungsschleife unter Beteiligung von Osteocalcin und Insulin. Auch wenn die Wirkung spezifisch für bestimmte Knochen sowie geschlechts- und zeitabhängig zu sein scheint, sind die Studienergebnisse, welche die Interaktion dieser drei Faktoren zeigen, teilweise noch widersprüchlich. Im vorliegenden Beitrag fassen wir die komplexen Effekte von Leptin, Insulin und Osteocalcin auf den Knochen- und Fettstoffwechsel zusammen.

Abstract

Leptin has been described to have a crucial role in bone homeostasis by systemic as well as local action. Systemically, leptin seems to inhibit bone formation controlled by a feedback loop including osteocalcin and insulin. Even though the action seems to be bone site specific, as well as gender- and time-dependent, the results showing the interaction of these three factors are in part still inconsistent. In this article the complex effects of leptin, insulin, and osteocalcin on bone and fat metabolism are summarized.

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Authors and Affiliations

  1. Arbeitsgruppe Transkription und Genexpression, Institut für Osteologie und Biomechanik (IOBM), Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland

    J. Luther & J.-P. David PhD

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  1. J. Luther
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J. Luther und J.-P. David geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

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A. Radbruch, Berlin

H. Schulze-Koops, München

Dies ist die dt. Übersetzung des Beitrags doi:10.1007/s00393-016-0143-x.

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Luther, J., David, JP. Knochen- und Fettgewebebildung. Z Rheumatol 75, 701–706 (2016). https://doi.org/10.1007/s00393-016-0166-3

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