Zeitschrift für Rheumatologie

, Volume 76, Issue 4, pp 351–356 | Cite as

Application value of laboratory indexes in the differential diagnosis of Henoch–Schoenlein purpura




The aim of this study was to explore the value of laboratory indexes in the differential diagnosis of Henoch–Schoenlein purpura (HSP).


Patients with HSP hospitalized at the Children’s Hospital of Zhejiang University School of Medicine between January 2010 and December 2014 were enrolled in this prospective study. In addition, septic patients with rash and patients with urticaria, simple hematuria, and acute appendicitis hospitalized during the same period were selected at random as differential diagnosis subjects, and healthy children were selected as normal controls. The levels of IgA, D‑dimer, fibrinogen (FIB), and platelet (PLT) and the platelet distribution width (PDW) of these individuals were tested and analyzed, and the ROC curve was used to determine the applicability of these indexes to differentiate between patients with HSP and other diseases easily confused with HSP, as well as to determine the efficacy of combined diagnosis.


There were remarkable differences in the levels of FIB, D‑dimer, IgA, PLT, and PDW among patients with HSP, sepsis patients with rash, patients with urticaria, simple hematuria, or acute appendicitis and healthy children (P < 0.01).


The levels of IgA, D‑dimer, and PLT can be applied separately for the differential diagnosis of HSP, and these indexes and FIB can be combined appropriately to improve the diagnostic efficacy.


Henoch–Schoenlein purpura Allergy Diagnosis IgA Platelets 

Praktischer Wert von Laborindizes bei der Differenzialdiagnose der Purpura Schoenlein-Henoch



Ziel der Studie war es, den Wert von Laborindizes für die Differenzialdiagnose der Purpura Schoenlein-Henoch (PSH) zu untersuchen.


In diese prospektive Studie aufgenommen wurden Patienten mit PSH, die in der Kinderklinik der Zhejiang University School of Medicine, Hangzhou, China, zwischen Januar 2010 und Dezember 2014 behandelt worden waren. Als Probanden für die Differenzialdiagnose wurden außerdem Patienten mit Sepsis und Exanthem sowie Patienten mit Urtikaria, einfacher Hämaturie und akuter Appendizitis zufällig ausgewählt, die im selben Zeitraum stationär behandelt wurden. Gesunde Kinder dienten als normale Kontrollen. Die Werte für Immunglobulin A (IgA), D‑Dimer, Fibrinogen (FIB) und Thrombozyten (PLT) sowie die Thrombozytenverteilungsbreite („platelet distribution width“, PDW) dieser Personen wurden bestimmt und ausgewertet. Anhand der Receiver-Operating-Characteristic(ROC)-Kurve wurde die Anwendbarkeit dieser Indizes für die Differenzierung zwischen Patienten mit PSH und anderen leicht mit PSH zu verwechselnden Erkrankungen sowie die Effektivität der kombinierten Diagnosestellung ermittelt.


Es bestanden deutliche Unterschiede bei den Werten für FIB, D‑Dimer, IgA, PLT und PDW zwischen Patienten mit PSH, Sepsispatienten mit Exanthem, Patienten mit Urikaria, einfacher Hämaturie oder akuter Appendizitis und gesunden Kindern (p < 0,01).


Die Werte für IgA, D‑Dimer und PLT können getrennt für die Differenzialdiagnose der PSH eingesetzt werden, außerdem können diese Indizes und FIB entsprechend kombiniert werden, um die diagnostische Effektivität zu verbessern.


Henoch-Schoenlein-Purpura Allergie Diagnose IgA Thrombozyten 



We are indebted to the parents and children who participated in this study for their time and generosity.


This project was supported by grants from the National Natural Science Foundation of China (Grant No. 81501760), Zhejiang Provincial Natural Science Foundation of China (Grant No. LQ16H050002), Zhejiang Provincial Healthy Science Foundation of China (Grant No. 2015KYB191). The funders did not take part in the study.

Compliance with ethical guidelines

Conflict of interest

W.-X. Shao, Q. Ye, and X.-J. Wang state that there are no conflicts of interest.

The accompanying manuscript does not include studies on humans or animals.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Hangzhou First People’s HospitalHangzhouChina
  2. 2.The Children’s Hospital of Zhejiang University School of MedicineHangzhouChina

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