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Rekrutierung osteogener Zellen an den Ort der Knochenbildung während Entwicklung und Frakturheilung

Recruitment of osteogenic cells to bone formation sites during development and fracture repair – German Version

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Zusammenfassung

Die Rekrutierung von Zellen der Osteoblastenlinie an den Ort der Knochenbildung ist wesentlich für die skeletale Entwicklung und Frakturheilung. In sich entwickelnden Knochen wandern Osteoprogenitorzellen in das Knorpelgewebe ein und bilden dort das primäre Ossifikationszentrum. In ähnlicher Weise infiltrieren und besiedeln osteogene Zellen das Kallusgewebe, das nach einer Verletzung gebildet wird. Ordnungsgemäße Knochenentwicklung und erfolgreiche Frakturheilung ist daher auf kontrollierte zeitliche und räumliche Orientierungssignale angewiesen. Dadurch werden die Zellen an die Stellen geführt, an denen die Neubildung von Knochen notwendig ist. Einige daran beteiligte zelluläre Mechanismen und molekulare Signalwege sind bereits aufgeklärt.

Abstract

Recruitment of osteoblast lineage cells to their bone-forming locations is essential for skeletal development and fracture healing. In developing bones, osteoprogenitor cells invade the cartilage mold to establish the primary ossification center. Similarly, osteogenic cells infiltrate and populate the callus tissue that is formed following an injury. Proper bone development and successful fracture repair must, therefore, rely on controlled temporal and spatial navigation cues guiding the cells to the sites where new bone formation is needed. Some cellular mechanisms and molecular pathways involved have been elucidated.

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Danksagung und Angaben zur Finanzierung

Die Forschungsarbeiten der Autoren werden mit Fördermitteln des Europäischen Forschungsrats (ERC Starting Grant 282131 an C. Maes) im Rahmen des 7. Forschungsrahmenprogramms der Europäischen Union (FP7/2007–2013) sowie mit Geldern der KU Leuven und der Flämischen Stiftung für Wissenschaftliche Forschung (FWO; Fördermittel an C. Maes) unterstützt. A.-M. Böhm ist Postdoktorand der FWO, N. Dirckx erhält ein Promotionsstipendium der Behörde für Innovation durch Wissenschaft und Technik (IWT).

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Authors and Affiliations

  1. Laboratory of Skeletal Cell Biology and Physiology (SCEBP), Skeletal Biology and Engineering Research Center (SBE), Department of Development and Regeneration, KU Leuven, Gasthuisberg O&N 1, Herestraat 49, Box 813, 3000, Leuven, Belgien

    A.-M. Böhm, N. Dirckx &  C. Maes

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  1. A.-M. Böhm
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  2. N. Dirckx
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  3. C. Maes
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Correspondence to C. Maes.

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Interessenkonflikt

A.-M. Böhm, N. Dirckx und C. Maes geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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A. Radbruch, Berlin

H. Schulze-Koops, München

Dieser Beitrag ist die deutsche Version von Recruitment of osteogenic cells to bone formation sites during development and fracture repair, DOI 10.1007/s00393-015-1574-5.

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Böhm, AM., Dirckx, N. & Maes, C. Rekrutierung osteogener Zellen an den Ort der Knochenbildung während Entwicklung und Frakturheilung. Z Rheumatol 75, 316–321 (2016). https://doi.org/10.1007/s00393-016-0065-7

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  • DOI: https://doi.org/10.1007/s00393-016-0065-7

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