Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis

A meta-analysis

FokI, BsmI und TaqI-Polymorphismus des Vitamin-D-Rezeptors und Anfälligkeit für rheumatoide Arthritis

Eine Metaanalyse

Zeitschrift für Rheumatologie volume 75, pages322–329(2016)Cite this article

Abstract

Objective

The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA).

Methods

Meta-analyses were conducted on the associations between the VDR FokI, BsmI, and TaqI polymorphisms and RA.

Results

A total of seven studies were considered in the meta-analysis, involving a total of 923 patients and 912 controls. Meta-analysis of the VDR FokI polymorphism showed no association between RA and the F allele in the entire studied cohort (odds ratio, OR = 1.1740, 95 % confidence interval, CI = 0.994–1.387, p = 0.059). However, stratification by ethnicity revealed a significant association between the F allele and RA in Europeans (OR = 1.402, 95 % CI = 1.126–1.746, p = 0.003). Furthermore, an association was found between RA and the VDR FokI polymorphism using both the dominant model and homozygote contrast. Meta-analysis revealed no association between RA and the VDR BsmI B and TaqI T polymorphisms in Europeans (OR for the B allele = 1.065, 95 % CI = 0.911–1.245, p = 0.427; OR for the T allele = 1.065, 95 % CI = 0.834–1.361, p = 0.613).

Conclusion

This meta-analysis suggests that the VDR FokI polymorphism is associated with susceptibility to RA in European populations.

Zusammenfassung

Ziel

Ziel der vorliegenden Studie war es zu untersuchen, ob Vitamin-D-Rezeptor(VDR)-Polymorphismen mit der Anfälligkeit für rheumatoide Arthritis (RA) in Zusammenhang stehen.

Methoden

Es wurden Metaanalysen zu den Assoziationen zwischen den FokI-, BsmI- und TaqI-Polymorphismen des VDR und RA durchgeführt.

Ergebnisse

In der Metaanalyse wurden 7 Studien berücksichtigt, die 923 Patienten und 912 Kontrollen umfassten. Die Metaanalyse des VDR-FokI-Polymorphismus ergab keine Assoziation zwischen RA und dem F-Allel in der gesamten untersuchten Kohorte (Odds Ratio, OR = 1,1740; 95 %-Konfidenzintervall, 95%-KI = 0,994–1,387; p = 0,059). Jedoch zeigte die Stratifizierung nach Ethnizität eine signifikante Assoziation zwischen dem F-Allel und RA bei Europäern (OR = 1,402; 95 %-KI = 1,126–1,746; p = 0,003). Darüber hinaus wurde eine Assoziation zwischen RA und dem VDR-FokI-Polymorphismus anhand des dominanten Modells und des homozygoten Kontrasts festgestellt. Wie die Metaanalyse zeigte, bestand keine Assoziation zwischen RA und den VDR-BsmI-B- und -TaqI-T-Polymorphismen bei Europäern (OR für das B-Allel = 1,065; 95 %-KI = 0,911–1,245; p = 0,427; OR für das T-Allel = 1,065; 95 %-KI = 0,834–1,361; p = 0,613).

Schlussfolgerung

Die vorliegende Metaanalyse liefert Hinweise darauf, dass der VDR-FokI-Polymorphismus mit der Anfälligkeit für RA in der europäischen Bevölkerung assoziiert ist.

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Acknowledgements

This study was supported in part by a grant from the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).

Compliance with ethical guidelines

Conflict of interest. G.G. Song, S.-C. Bae, and Y.H. Lee state that there are no conflicts of interest.

The accompanying manuscript does not include studies on humans or animals.

Author information

Affiliations

  1. Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126-1, Anam-dong 5-ga, Seongbuk-gu, 136–705, Seoul, Korea

    G.G. Song & Y.H. Lee MD, PhD

  2. Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea

    S.-C. Bae

Authors
  1. G.G. Song
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  2. S.-C. Bae
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  3. Y.H. Lee MD, PhD
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Correspondence to Y.H. Lee MD, PhD.

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Song, G., Bae, SC. & Lee, Y. Vitamin D receptor FokI, BsmI, and TaqI polymorphisms and susceptibility to rheumatoid arthritis. Z Rheumatol 75, 322–329 (2016). https://doi.org/10.1007/s00393-015-1581-6

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Keywords

  • Immune system
  • Autoimmune diseases
  • Hormone receptors, nuclear
  • MEDLINE
  • Linkage disequilibrium

Schlüsselwörter

  • Immunsystem
  • Autoimmunkrankheit
  • Hormonrezeptoren, nukleäre
  • MEDLINE
  • Kopplungsungleichgewicht