Skip to main content

Advertisement

SpringerLink
Log in

Immungerontologie – Alternsforschung

Immunogerontology – Research into aging

  • Neues aus der Forschung
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Araki K, Ellebedy AH, Ahmed R (2011) TOR in the immune system. Curr Opin Cell Biol 23:707–715

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Arnold CR, Wolf J, Brunner S et al (2011) Gain and loss of T cell subsets in old age – age-related reshaping of the T cell repertoire. J Clin Immunol 31:137–146

    Article  PubMed  Google Scholar 

  3. Brunner S, Herndler-Brandstetter D, Arnold CR et al (2012) Upregulation of miR-24 is associated with a decreased DNA damage response upon etoposide treatment in highly differentiated CD8(+) T cells sensitizing them to apoptotic cell death. Aging Cell 11:579–587

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Brunner S, Herndler-Brandstetter D, Weinberger B et al (2011) Persistent viral infections and immune aging. Ageing Res Rev 10:362–369

    Article  CAS  PubMed  Google Scholar 

  5. Cambier J (2005) Immunosenescence: a problem of lymphopoiesis, homeostasis, microenvironment, and signaling. Immunol Rev 205:5–6

    Article  PubMed  Google Scholar 

  6. Del Giudice G, Weinberger B, Grubeck-Loebenstein B (2015) Vaccines for the elderly. Gerontology 61(3):203–210

    Google Scholar 

  7. Den Braber I, Mugwagwa T, Vrisekoop N et al (2012) Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans. Immunity 36:288–297

    Article  Google Scholar 

  8. Franceschi C, Bonafe M, Valensin S et al (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254

    Article  CAS  PubMed  Google Scholar 

  9. Franceschi C, Campisi J (2014) Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci 69(Suppl 1):S4–S9

    Article  PubMed  Google Scholar 

  10. Gavazzi G, Krause KH (2002) Ageing and infection. Lancet Infect Dis 2:659–666

    Article  PubMed  Google Scholar 

  11. Geiger H, Rudolph KL (2009) Aging in the lympho-hematopoietic stem cell compartment. Trends Immunol 30:360–365

    Article  CAS  PubMed  Google Scholar 

  12. George AJ, Ritter MA (1996) Thymic involution with ageing: obsolescence or good housekeeping? Immunol Today 17:267–272

    Article  CAS  PubMed  Google Scholar 

  13. Guarente L (2013) Calorie restriction and sirtuins revisited. Genes Dev 27:2072–2085

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Herndler-Brandstetter D, Landgraf K, Tzankov A et al (2012) The impact of aging on memory T cell phenotype and function in the human bone marrow. J Leukoc Biol 91:197–205

    Article  PubMed  Google Scholar 

  15. Hubbard BP, Sinclair DA (2014) Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci 35:146–154

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Larbi A, Franceschi C, Mazzatti D et al (2008) Aging of the immune system as a prognostic factor for human longevity. Physiology (Bethesda) 23:64–74

  17. Pritz T, Lair J, Ban M et al (2015) Plasma cell numbers decrease in bone marrow of old patients. Eur J Immunol 45:738–746

    Article  CAS  PubMed  Google Scholar 

  18. Shaw AC, Joshi S, Greenwood H et al (2010) Aging of the innate immune system. Curr Opin Immunol 22:507–513

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Signer RA, Montecino-Rodriguez E, Dorshkind K (2007) Aging, B lymphopoiesis, and patterns of leukemogenesis. Exp Gerontol 42:391–395

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Skerka C, Lauer N, Weinberger AA et al (2007) Defective complement control of factor H (Y402H) and FHL-1 in age-related macular degeneration. Mol Immunol 44:3398–3406

    Article  CAS  PubMed  Google Scholar 

  21. Zender L, Rudolph KL (2009) Keeping your senescent cells under control. Aging 1:438–441

    CAS  PubMed Central  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. B. Grubeck-Loebenstein gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Universitätsprofessorin für Immungerontologie, Leiterin des Forschungsinstitut für Biomedizinische Alternsforschung, Universität Innsbruck, Rennweg 10, 6020, Innsbruck, Österreich

    B. Grubeck-Loebenstein

Authors
  1. B. Grubeck-Loebenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to B. Grubeck-Loebenstein.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Grubeck-Loebenstein, B. Immungerontologie – Alternsforschung. Z Rheumatol 74, 435–437 (2015). https://doi.org/10.1007/s00393-014-1562-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-014-1562-1

Search

Navigation