OVERLOAD of joints and its role in osteoarthritis
Intact joints are necessary for skeletal function and mobility in daily life. A healthy musculoskeletal system is the basis for a functional cardiovascular system as well as an intact immune system. Locomotion, physiotherapy, and various forms of patient activity are essential clinical therapies used in the treatment of neurodegeneration, stroke, diabetes, and cancer. Mobility is substantially impaired with degeneration of joints and, in advanced stages, nighttime pain and sleep disturbance are particularly cumbersome.
Osteoarthritis (OA) is also known as degenerative joint disease. OA involves structural and compositional changes in the articular cartilage, as well as in the calcified cartilage, subchondral cortical bone, subchondral cancellous bone, meniscus, joint capsular tissue, and synovium; which eventually lead to degeneration of these tissues comprising synovial joints.
Epidemiology and treatment of osteoarthritis
OA is the most prevalent joint disease, affecting over...
KeywordsArticular Cartilage Calcify Cartilage Mechanical Overload Axial Malalignment Intact Joint
We thank Adam Trepczynski and Heide Boeth for designing figures and providing insights related to our research approach. This work was supported by a grant from the Bundesministerium für Bildung und Forschung (OVERLOAD–PrevOP consortium). The Berlin-Brandenburg School for Regenerative Therapies is funded by the Deutsche Forschungsgemeinschaft, GSC 203.
Compliance with ethical guidelines
Conflict of interest. B.M. Willie, T. Pap, C. Perka, C.O. Schmidt, F. Eckstein, A. Arampatzis, H.-C. Hege, H. Madry, A. Vortkamp, and G.N. Duda state that there are no conflicts of interest.
The accompanying manuscript does not include studies on humans or animals.
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