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Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis

A meta-analysis

Polymorphismen von MMP-1 und MMP-3 und die Prädisposition für rheumatoide Arthritis

Eine Metaanalyse

  • Aktuelles aus der Immunologie
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Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Abstract

Objective

To determine the correlation between rheumatoid arthritis (RA) and polymorphisms of the matrix metalloproteinase (MMP) genes MMP-1 and MMP-3.

Background

The 1607 1G/2G and 1171 5A/6A polymorphisms of MMP genes MMP-1 and MMP-3 have been discovered to be functional, and may be conducive to RA. In order to determine whether MMP-1 and MMP-3 gene polymorphisms correlate with RA development, we performed a meta-analysis to further validate the function of these polymorphisms in RA.

Methods

We searched PubMed, ISI Web of Knowledge, MEDLINE, Embase, Google Scholar Chinese Biomedical Literature Database, and Wanfang Data to identify all published case–control studies on the MMP-1-1607 1G/2G and MMP-3-1171 5A/6A polymorphisms and RA risk. Odds ratios (OR) and 95 % confidence intervals (CI) were used to estimate the association between these polymorphisms and RA risk.

Results

After being assessed, five articles fulfilled the inclusion criteria. To assess associations, the pooled OR with 95 % CIs was calculated. Neither the MMP-1-1607 1G/2G nor the MMP-3-1171 5A/6A polymorphism was statistically associated with RA in any of the five models, nor in the subgroup analysis models of MMP-3-1171 5A/6A in Caucasian and Asian patients.

Conclusion

Our study suggests that MMP-1 and MMP-3 polymorphisms have no significant association with the risk of RA.

Zusammenfassung

Ziel

Ziel war die Untersuchung der Korrelation zwischen rheumatoider Arthritis (RA) und Polymorphismen der Matrixmetalloproteinase(MMP)-Gene MMP-1 und MMP-3.

Hintergrund

Die 1607-1G/2G- und 1171-5A/6A-Polymorphismen der MMP-Gene MMP-1 und MMP-3 haben sich als funktionell herausgestellt und tragen möglicherweise zur Entstehung der RA bei. Um zu ermitteln, ob MMP-1- und MMP-3-Gen-Polymorphismen mit der Entstehung der RA korreliert sind, führten die Autoren eine Metaanalyse zur weiteren Validierung der Funktion dieser Polymorphismen für die RA durch.

Methoden

Durchsucht wurden die Datenbanken PubMed, ISI Web of Knowledge, MEDLINE, Embase, Google Scholar Chinese Biomedical Literature Database und Wanfang Data, um sämtliche veröffentlichten Fall-Kontroll-Studien zu den MMP-1-1607-1G/2G- und MMP-3-1171-5A/6A-Polymorphismen sowie zum RA-Risiko zu erfassen. Mithilfe der Odds Ratio (OR) und des 95 %-Konfidenzintervalls (95%-KI) wurde die Assoziation zwischen diesen Polymorphismen und dem RA-Risiko ermittelt.

Ergebnisse

Nach entsprechender Prüfung erfüllten 5 Artikel die Einschlusskriterien. Um eine etwaige Assoziation festzustellen, wurde die gepoolte OR bei einem 95%-KI berechnet. Der MMP-1-1607-1G/2G- und der MMP-3-1171-5A/6A-Polymorphismus waren statistisch weder in einem der 5 Modelle mit der RA assoziiert noch in den Subgruppenanalysemodellen von MMP-3-1171 5A/6A bei kaukasischen und asiatischen Patienten.

Schlussfolgerung

Der vorliegenden Studie zufolge besteht für die MMP-1- und MMP-3-Polymorphismen keine signifikante Assoziation mit dem RA-Risiko.

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References

  1. Harris ED Jr (1990) Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med 322:1277–1289

    Article  PubMed  Google Scholar 

  2. Decock J, Paridaens R, Ye S (2008) Genetic polymorphisms of matrix metalloproteinases in lung, breast and colorectal cancer. Clin Genet 73:197–211

    Article  CAS  PubMed  Google Scholar 

  3. Ye S (2000) Polymorphism in matrix metalloproteinase gene promoters: implication in regulation of gene expression and susceptibility of various diseases. Matrix Biol 19:623–629

    Article  CAS  PubMed  Google Scholar 

  4. Scherer S, Souza TB de, Paoli J de et al (2010) Matrix metalloproteinase gene polymorphisms in patients with rheumatoid arthritis. Rheumatol Int 30:369–373

    Article  CAS  PubMed  Google Scholar 

  5. Abd-Allah SH, Shalaby SM, Pasha HF et al (2012) Variation of matrix metalloproteinase 1 and 3 haplotypes and their serum levels in patients with rheumatoid arthritis and osteoarthritis. Genet Test Mol Biomarkers 16:15–20

    Article  CAS  PubMed  Google Scholar 

  6. Constantin A, Lauwers-Cances V, Navaux F et al (2002) Collagenase-1 (MMP-1) and HLA-DRB1 gene polymorphisms in rheumatoid arthritis: a prospective longitudinal study. J Rheumatol 29:15–20

    PubMed  Google Scholar 

  7. Zhou L, Gao Q (2014) Genetic polymorphism of matrix metallopoteiase 3 and correlation between its mRNA expression and rheumatoid arthritis. J Clin Med Pract 18:16–19

    CAS  Google Scholar 

  8. Constantin A, Lauwers-Cances V, Navaux F et al (2002) Stromelysin 1 (matrix metalloproteinase 3) and HLA-DRB1 gene polymorphisms: association with severity and progression of rheumatoid arthritis in a prospective study. Arthritis Rheum 46:1754–1762

    Article  CAS  PubMed  Google Scholar 

  9. DerSimonian R, Kacker R (2007) Random-effects model for meta-analysis of clinical trials: an update. Contemp Clin Trials 28:105–114

    Article  PubMed  Google Scholar 

  10. Rutter JL, Mitchell TI, Buttice G et al (1998) A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter creates an Ets binding site and augments transcription. Cancer Res 58:5321–5325

    CAS  PubMed  Google Scholar 

  11. Munafo MR, Flint J (2004) Meta-analysis of genetic association studies. Trends Genet 20:439–444

    Article  CAS  PubMed  Google Scholar 

Download references

Compliance with ethical guidelines

Conflict of interest. C. Zhang, L. Chen, and Y. Gu state that there are no conflicts of interest. The accompanying manuscript does not include studies on humans or animals.

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Correspondence to L. Chen Ph.D.

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Zhang, C., Chen, L. & Gu, Y. Polymorphisms of MMP-1 and MMP-3 and susceptibility to rheumatoid arthritis. Z. Rheumatol. 74, 258–262 (2015). https://doi.org/10.1007/s00393-014-1537-2

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  • DOI: https://doi.org/10.1007/s00393-014-1537-2

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