Abstract
Objective
The aim in this study was to determine whether solute carrier family 22, member 4 (SLC22A4), and runt-related transcription factor 1 (RUNX1) polymorphisms are associated with susceptibility to rheumatoid arthritis (RA) in populations of different ethnicities.
Methods
We conducted a literature search using the MEDLINE and EMBASE, and performed a meta-analysis using a fixed or random effects model.
Results
A total of 26 comparative studies from 14 articles met the study inclusion criteria. Studies on the SLC22A4 polymorphism involved 12,458 RA patients and 9283 controls, and studies on the RUNX1 polymorphism involved 3958 RA patients and 3773 controls. The meta-analysis showed no association between the 22 + 21 genotype of the SLC22A4 F1 and RA in overall group [odds ratio (OR) 1.074, 95 % confidence interval (CI) 0.952–1.212, p = 0.245]. After stratification by ethnicity, the meta-analysis indicated that the 22 + 21 genotype of the SLC22A4 F1 was associated significantly with RA in the East Asian population, but not in the European population (OR 1.124, 95 % CI 1.018–1.240, p = 0.021; OR 0.981, 95 % CI 0.773–1.243, p = 0.871).
Conclusion
This meta-analysis demonstrates that the SLC22A4 F1 polymorphism is associated with susceptibility to RA in East Asians, but not in Europeans.
Zusammenfassung
Ziel
Ziel der Studie war es zu ermitteln, ob Polymorphismen des 4. Mitglieds der SLC(solute carrier“)-Familie 22 (SLC22A4) und des „runt-related“ Transkriptionsfaktors 1 (RUNX1) in verschiedenen Ethnien mit der Suszeptibilität für rheumatoide Arthritis assoziiert sind.
Methoden
Nach Publikationen wurde in den Datenbanken MEDLINE und EMBASE gesucht, die Metaanalyse wurde nach einem „fixed or random effects“ Modell durchgeführt.
Ergebnisse
Insgesamt 26 vergleichende Studien aus 14 Publikationen erfüllten die Einschlusskriterien. In die Studien zum SLC22A4-Polymorphismus waren 12,458 RA-Patienten und 9283 Kontrollpersonen eingeschlossen, in die zum RUNX1-Polymorphismen 3958 bzw. 3773. In der Gruppe insgesamt ergab die Metaanalyse keine Assoziation zwischen dem 22 + 21-Genotyp von SLC22A4 F1 und RA (Odds Ratio, OR, 1,074, 95 %-Konfidenzintervall, KI, 0,952–1,212, p = 0,245). Bei Stratifikation nach ethnischer Zugehörigkeit zeigte sich eine statistisch signifikante Assoziation zwischen dem 22 + 21-Genotyp von SLC22A4 F1 und RA im ostasiatischen Kollektiv (OR 1,124, 95 %-KI 1,018–1,240, p = 0,021), nicht dagegen im europäischen Kollektiv (OR 0,981, 95 %-KI 0,773–1,243, p = 0,871).
Fazit
Die Metaanalyse weist eine Assoziation zwischen dem SLC22A4-F1-Polymorphismus und der Suszeptibilität für RA bei Ostasiaten nach, nicht dagegen bei Europäern.
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Acknowledgments
This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health & Welfare, Republic of Korea (HI12C1834).
Compliance with ethical guidelines
Conflict of interest. Y.H. Lee, S.-C. Bae, J.-H. Kim, Y.H. Seo, S.J. Choi, J.D. Ji, and G.G. Song state that there are no conflicts of interest. The accompanying manuscript does not include studies on humans or animals.
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Lee, Y., Bae, SC., Kim, JH. et al. Meta-analysis of SLC22A4 and RUNX1 polymorphisms. Z Rheumatol 74, 351–358 (2015). https://doi.org/10.1007/s00393-014-1447-3
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DOI: https://doi.org/10.1007/s00393-014-1447-3