Literatur
Holliday R (2006) Epigenetics: a historical overview. Epigenetics 1(2):76–80
Hughes V (2014) Epigenetics: the sins of the father. Nature 507(7490):22–24
Jeffries MA, Dozmorov M, Tang Y et al (2011) Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics 6(5):593–601
Lin SY, Hsieh SC, Lin YC et al (2012) A whole genome methylation analysis of systemic lupus erythematosus: hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity. Genes Immun 13(3):214–220
Wang Y, Fan PS, Kahaleh B (2006) Association between enhanced type I collagen expression and epigenetic repression of the FLI1 gene in scleroderma fibroblasts. Arthritis Rheum 54(7):2271–2279
Huber LC, Distler JH, Moritz F et al (2007) Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis. Arthritis Rheum 56(8):2755–2764
Brueckner B, Kuck D, Lyko F (2007) DNA methyltransferase inhibitors for cancer therapy. Cancer J 13(1):17–22
Dees C, Akhmetshina A, Busch N et al (2009) Inhibitors of DNA methyltransferases exert potent anti-fibrotic effects via re-activation of socs-3. Ann Rheum Dis 68(Suppl3):94
Vettori SBM, Iwamoto N, Maurer B et al (2011) Anti-fibrotic effects of microRNA-145 in systemic sclerosis via a multi-step regulation of TGF-Beta/CTGF signaling. Arthritis Rheum 63(Suppl 10):2536
Karouzakis E, Gay RE, Michel BA et al (2009) DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 60(12):3613–3622
Karouzakis E, Rengel Y, Jungel A et al (2011) DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun 12(8):643–652
Stanczyk J, Pedrioli DM, Brentano F et al (2008) Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum 58(4):1001–1009
Kurowska-Stolarska M, Alivernini S, Ballantine LE et al (2011) MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A 108(27):11193–11198
Bluml S, Bonelli M, Niederreiter B et al (2011) Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum 63(5):1281–1288
Pandis I, Ospelt C, Karagianni N et al (2012) Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis 71(10):1716–1723
Niederer F, Trenkmann M, Ospelt C et al (2012) Down-regulation of microRNA-34a* in rheumatoid arthritis synovial fibroblasts promotes apoptosis resistance. Arthritis Rheum 64(6):1771–1779
Filkova M, Aradi B, Senolt L et al (2013) Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis. Ann Rheum Dis (Epub ahead of print)
Zhou Q, Haupt S, Kreuzer JT et al (2014) Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis. Ann Rheum Dis (Epub ahead of print)
Gray SG (2013) Perspectives on epigenetic-based immune intervention for rheumatic diseases. Arthritis Res Ther 15(2):207
Hewings DS, Rooney TP, Jennings LE et al (2012) Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions. J Med Chem 55(22):9393–9413
Neidhart M, Karouzakis E, Jungel A et al (2014) Inhibition of spermidine/spermine n1-acetyltransferase activity: a new therapeutic concept in rheumatoid arthritis. Arthritis Rheumatol 66(7):1723–1733
Interessenkonflikt
A. Ramming, J.H.W. Distler, G. Schett, S. Gay und A. Jüngel geben an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ramming, A., Distler, J., Schett, G. et al. Epigenetische Modifikationen bei Autoimmunerkrankungen. Z. Rheumatol. 73, 636–638 (2014). https://doi.org/10.1007/s00393-014-1388-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00393-014-1388-x