Alten R, Märker-Hermann E (2010) Selektive Kostimulationsblockade. CTLA4-Ig (Abatacept). Z Rheumatol 69:601–607
CAS
PubMed
Article
Google Scholar
Furst DE, Keystone EC, So AK et al (2013) Updated consensus statement on biological agents for the treatment of rheumatic diseases, 2012. Ann Rheum Dis 72(Suppl III) ii2–ii34
Kremer JM, Genant HK, Moreland LW et al (2006) Effects of abatacept in patients with methotrexate-resistant active rheumatoid arthritis: a randomized trial. Ann Intern Med 144:865–876
CAS
PubMed
Article
Google Scholar
Genovese MC, Becker JC, Schiff M et al (2005) Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition. N Engl J Med 353:1114–1123
CAS
PubMed
Article
Google Scholar
Krüger K, Wollenhaupt J, Albrecht K et al (2012) S1-Leitlinie der DGRh zur sequenziellen medikamentösen Therapie der rheumatoiden Arthritis 2012. Z Rheumatol 71:592–603
PubMed
Article
Google Scholar
Manger B, Michels H, Nüsslein H et al (2007) Neufassung der Empfehlungen der DGRh zur Therapie mit Tumornekrosefaktor-hemmenden Wirkstoffen bei entzündlich-rheumatischen Erkrankungen (Stand März 2006). Z Rheumatol 66:72–75
CAS
PubMed
Article
Google Scholar
Kim PS, Ho GY, Prete PE, Furst DE (2012) Safety and efficacy of abatacept in eight rheumatoid arthritis patients with chronic hepatitis B. Arthritis Care Res 64:1265–1268
CAS
Google Scholar
Fachinformation ORENCIA®, 2013
Moreland LW, Alten R, Bosch F van den et al (2002) Costimulatory blockade in patients with rheumatoid arthritis: a pilot, dose-finding, double-blind, placebo-controlled clinical trial evaluating CTLA-4Ig and LEA29Y eighty-five days after the first infusion. Arthritis Rheum 46:1470–1479
CAS
PubMed
Article
Google Scholar
Schiff MH, Pritchard C, Huffstutter JE et al (2009) The 6-month safety and efficacy of abatacept in patients with rheumatoid arthritis who underwent a washout after anti-TNF therapy or were directly switched to abatacept: the ARRIVE-trial. Ann Rheum Dis 68:1708–1714
CAS
PubMed Central
PubMed
Article
Google Scholar
Tay L, Leon F, Vratsanos G et al (2007) Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, open-label, parallel group study in healthy subjects. Arthritis Res Ther 9:R38
PubMed Central
PubMed
Article
Google Scholar
Ribeiro AC, Laurindo IM, Guedes LK et al (2013) Abatacept and reduced immune response to pandemic 2009 influenza A/H1N1 vaccination in patients with rheumatoid arthritis. Arthritis Care Res 65:476–480
CAS
Article
Google Scholar
Nishida K, Nasu Y, Hashizume K et al (2014) Abatacept management during the perioperative period in patients with rheumatoid arthritis: report on eight orthopaedic procedures. Mod Rheumatol doi:10.3109/14397595.2013.874758
Google Scholar
Krüger K, Albrecht K, Rehart S et al (2014) Empfehlungen der Deutschen Gesellschaft für Rheumatologie zur perioperativen Vorgehensweise unter Therapie mit DMARDs und Biologika bei entzündlich-rheumatischen Erkrankungen. Z Rheumatol 73:77–84
PubMed
Article
Google Scholar
Genant HK, Peterfy CG, Westhovens R et al (2008) Abatacept inhibits progression of structural damage in rheumatoid arthritis: results from the longterm extension of the AIM trial. Ann Rheum Dis 67:1084–1089
CAS
PubMed Central
PubMed
Article
Google Scholar
Kremer JM, Russell AS, Emery P et al (2011) Long-term safety, efficacy, and inhibition of radiographic progression with abatacept treatment in patients with rheumatoid arthritis and an inadequate response to methotrexate: 3-year results from the AIM trial. Ann Rheum Dis 70:1826–1830
CAS
PubMed Central
PubMed
Article
Google Scholar
Genovese MC, Schiff M, Luggen M et al (2008) Efficacy and safety of the selective co-stimulation modulator abatacept following 2 years of treatment in patients with rheumatoid arthritis and an inadequate response to anti-tumour necrosis factor therapy. Ann Rheum Dis 67:547–554
CAS
PubMed
Article
Google Scholar
Schiff M, Keiserman M, Codding C et al (2008) Efficacy and safety of abatacept or infliximab vs placebo in ATTEST: a phase III, multicentre, randomised, double-blind, placebo-controlled study in patients with rheumatoid arthritis and an inadequate response to methotrexate. Ann Rheum Dis 67:1096–1103
CAS
PubMed Central
PubMed
Article
Google Scholar
Weinblatt ME, Schiff M, Valente R et al (2013) Head-to-head comparison of subcutaneous abatacept vs adalimumab for rheumatoid arthritis. Findings of a phase IIIb, multinational, prospective, randomized study. Arthritis Rheum 65:28–38
CAS
PubMed Central
PubMed
Article
Google Scholar
Schiff M, Weinblatt ME, Valente R et al (2014) Head-to-head comparison of subcutaneous abatacept versus adalimumab for rheumatoid arthritis: two-year efficacy and safety findings from AMPLE trial. Ann Rheum Dis 73:86–94
CAS
PubMed Central
PubMed
Article
Google Scholar
Emery P, Durez P, Dougados M et al (2010) Impact of T-cell costimulation modulation in patients with undifferentiated inflammatory arthritis or very early rheumatoid arthritis: a clinical and imaging study of abatacept (the ADJUST trial). Ann Rheum Dis 69:510–516
CAS
PubMed Central
PubMed
Article
Google Scholar
Westhovens R, Robles M, Ximenes AC et al (2009) Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis 68:1870–1877
CAS
PubMed Central
PubMed
Article
Google Scholar
Wells AF, Westhovens R, Reed DM et al (2011) Abatacept plus methotrexate provides incremental clinical benefits versus methotrexate alone in methotrexate-naive patients with early rheumatoid arthritis who achieve radiographic nonprogression. J Rheumatol 38:2362–2368
CAS
PubMed
Article
Google Scholar
Genovese MC, Covarrubias A, Leon G et al (2011) Subcutaneous abatacept versus intravenous abatacept. A pahse III noninferiority study in patients with an inadequate response to methotrexate. Arthritis Rheum 63:2854–2864
CAS
PubMed Central
PubMed
Article
Google Scholar
Keystone EC, Kremer JM, Russell A et al (2012) Abatacept in subjects who switch from intravenous to subcutaneous therapy: results from the phase IIIb ATTUNE study. Ann Rheum Dis 71:857–861
CAS
PubMed
Article
Google Scholar
Kremer JM, Dougados M, Emery P et al (2005) Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept. Arthritis Rheum 52:2263–2271
CAS
PubMed
Article
Google Scholar
Genovese MC, Schiff M, Luggen M et al (2012) Longterm safety and efficacy of abatacept through 5 years of treatment in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor inhibitor therapy. J Rheumatol 39:1546–1554
CAS
PubMed
Article
Google Scholar
Weinblatt ME, Moreland LW, Westhovens R et al (2013) Safety of abatacept administered intravenously in treatment of rheumatoid arthritis: integrated analyses of up to 8 years treatment from the abatacept clinical trial program. J Rheumatol 40:787–797
CAS
PubMed
Article
Google Scholar
Weinblatt M, Combe B, Covucci A et al (2006) safety of the selective co-stimulation modulator abatacept in rheumatoid arthritis patients receiving background biologic and non-biologic DMARDs: a 1 year randomised study. Arthritis Rheum 54:2807–2816
CAS
PubMed
Article
Google Scholar
Weinblatt M, Schiff M, Goldman A et al (2007) Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann Rheum Dis 66:228–234
CAS
PubMed Central
PubMed
Article
Google Scholar
Salliot C, Dougados M, Gossec L (2009) Risk of serious infections during rituximab, abatacept and anakinra therapies for rheumatoid arthritis: meta-analyses of randomized placebo-controlled trials. Ann Rheum Dis 68:25–32
CAS
PubMed Central
PubMed
Article
Google Scholar
Curtis JR, Xie F, Chen L et al (2011) The comparative risk of serious infections among rheumatoid arthritis patients starting or switching biological agents. Ann Rheum Dis 70:1401–1406
CAS
PubMed Central
PubMed
Article
Google Scholar
Simon TA, Askling J, Lacaille D et al (2010) Infections requiring hospitalization in the abatacept clinical development program: an epidemiological assessment. Arthritis Res Ther 12:R67
PubMed Central
PubMed
Article
Google Scholar
Simon TA, Smitten AL, Franklin J et al (2009) Malignancies in the rheumatoid arthritis abatacept clinical development programme: an epidemiological assessment. Ann Rheum Dis 68:1819–1826
CAS
PubMed Central
PubMed
Article
Google Scholar
Haggerty HG, Abbott MA, Reilly TP, DeVona DA et al (2007) Evaluation of immunogenicity of the T cell costimulation modulator abatacept in patients treated for rheumatoid arthritis. J Rheumatol 34:2365–2373
CAS
PubMed
Google Scholar
Nash P, Nayiager S, Genovese MC et al (2013) Immunogenicity, safety, and efficacy of abatacept administered subcutaneously with or without background methotrexate in patients with rheumatoid arthritis: results from a phase III international, multicenter, parallel-arm, open-label study. Arthritis Care Res 65:718–728
CAS
Article
Google Scholar
Kaine J, Gladstein G, Strusberg I et al (2012) Evaluation of abatacept administered subcutaneously in adults with active rheumatoid arthritis: impact of withdrawal and reintroduction on immunogenicity, efficacy and safety (phase IIIb ALLOW study). Ann Rheum Dis 71:38–44
CAS
PubMed Central
PubMed
Article
Google Scholar
Ruperto N, Lovell DJ, Quartier P et al (2008) Abatacept in children with juvenile idiopathic arthritis: a randomised, double blind, placebo-controlled withdrawal trial. Lancet 372:383–392
CAS
PubMed
Article
Google Scholar
Dueckers G, Guellac N, Arbogast M et al (2012) Evidence and consensus based GKJR guidelines for the treatment of juvenile idiopathic arthritis. Clin Immunol 142:176–193
CAS
PubMed
Article
Google Scholar
Record JL, Beukelman T, Cron RQ (2011) Combination therapy of abatacept and anakinra in children with refractory systemic juvenile idiopathic arthritis: a retrospective case series. J Rheumatol 38:180–181
PubMed
Article
Google Scholar
Zulian F, Balzarin M, Falcini F et al (2010) Abatacept for severe anti-tumor necrosis factor alpha refractory juvenile idiopathic arthritis-related uveitis. Arthritis Care Res 62:821–825
CAS
Article
Google Scholar
Ruperto N, Lovell DJ, Quartier P et al (2010) Long-term safety and efficiency of abatocept in children with juvenile idiopathic arthritis. Arthritis Rheum 62:1792–1802
CAS
PubMed
Article
Google Scholar