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Geschlechtsspezifische Unterschiede des Immunsystems

Sex-specific differences of the immune system

Zusammenfassung

Hintergrund

Geschlechtsspezifische Unterschiede in Prävalenz und Ausprägung von immunologischen Erkrankungen sind seit Langem bekannt. Dennoch beginnen wir erst langsam, die Ursachen zu verstehen.

Material und Methoden

Es wurde die aktuelle Literatur zum Thema durchgesehen und zusammengestellt.

Ergebnis

Technische Fortschritte in der Gensequenzierung, neue Erkenntnisse über das Mikrobiom des Darms und verstärkte Sensibilität für geschlechts- und genderabhängige Risikofaktoren für Infektionen und Autoimmunität haben unser Verständnis des Immunsystems verändert.

Schlussfolgerung

Die Erkenntnisse der letzten Jahre werden nicht nur Diagnostik und Früherkennung dieser Erkrankungen verbessern, sondern auch die Forschung, Prävention und Therapie von Infektionen und Autoimmunerkrankungen prägen.

Abstract

Background

Sex-specific differences in the prevalence and severity of immune disorders are well-known phenomena; however, it is only recently that we have begun to understand the possible causes of such differences.

Material and methods

A literature search on this topic was carried out and the results are summarized.

Results

In the last few years research has been guided by technological advances in gene sequencing and new insights into the microbiome of the gut, as well as an awareness of sex- and gender-specific risk factors for infections and autoimmunity.

Conclusion

The knowledge acquired in recent years will not only improve diagnostics and early identification of these disorders but also influence future research, prevention and therapy of infections and autoimmune diseases.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. G. Riemekasten und E. Siegert geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Correspondence to G. Riemekasten.

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Riemekasten, G., Siegert, E. Geschlechtsspezifische Unterschiede des Immunsystems. Z. Rheumatol. 73, 600–606 (2014). https://doi.org/10.1007/s00393-014-1357-4

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  • DOI: https://doi.org/10.1007/s00393-014-1357-4

Schlüsselwörter

  • Immunologie
  • Gender
  • Geschlechtshormone
  • Geschlechtschromosome
  • Autoimmunität

Keywords

  • Immunology
  • Gender
  • Sex hormones
  • Sex chromosomes
  • Autoimmunity