Zusammenfassung
Hintergrund
Geschlechtsspezifische Unterschiede in Prävalenz und Ausprägung von immunologischen Erkrankungen sind seit Langem bekannt. Dennoch beginnen wir erst langsam, die Ursachen zu verstehen.
Material und Methoden
Es wurde die aktuelle Literatur zum Thema durchgesehen und zusammengestellt.
Ergebnis
Technische Fortschritte in der Gensequenzierung, neue Erkenntnisse über das Mikrobiom des Darms und verstärkte Sensibilität für geschlechts- und genderabhängige Risikofaktoren für Infektionen und Autoimmunität haben unser Verständnis des Immunsystems verändert.
Schlussfolgerung
Die Erkenntnisse der letzten Jahre werden nicht nur Diagnostik und Früherkennung dieser Erkrankungen verbessern, sondern auch die Forschung, Prävention und Therapie von Infektionen und Autoimmunerkrankungen prägen.
Abstract
Background
Sex-specific differences in the prevalence and severity of immune disorders are well-known phenomena; however, it is only recently that we have begun to understand the possible causes of such differences.
Material and methods
A literature search on this topic was carried out and the results are summarized.
Results
In the last few years research has been guided by technological advances in gene sequencing and new insights into the microbiome of the gut, as well as an awareness of sex- and gender-specific risk factors for infections and autoimmunity.
Conclusion
The knowledge acquired in recent years will not only improve diagnostics and early identification of these disorders but also influence future research, prevention and therapy of infections and autoimmune diseases.
Literatur
Gleicher N, Barad DH (2007) Gender as risk factor for autoimmune diseases. J Autoimmun 28:1–6
Lockshin MD (2002) Sex ratio and rheumatic disease: excerpts from an Institute of Medicine report. Lupus 11:662–666
Klein SL, Jedlicka A, Pekosz A (2010) The Xs and Y of immune responses to viral vaccines. Lancet infect Dis 10:338–349
Green MS (1992) The male predominance in the incidence of infectious diseases in children: a postulated explanation for disparities in the literature. Int J Epidemiol 21:381–386
Dillon SP, Kao L, Kaufman KM et al (2011) Triple X syndrome (47,XXX) increases the risk and accelerates the onset of systemic lupus erythematosus and Sjögren’s syndrome: support for a gene-dose effect from the X chromosome. Arthritis Rheum 63:643
Smith-Bouvier DL, Divekar AA, Sasidhar M et al (2008) A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med 205:1099–1108
Libert C, Dejager L, Pinheiro I (2010) The X chromosome in immune functions: when a chromosome makes the difference. Nat Rev Immunol 10:594–604
Zhou Y, Yuan J, Pan Y et al (2009) T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus. Clin Immunol 132:362–370
Finlay AY, Kingston HM, Holt PJA (1983) Chronic granulomatous disease carrier geno-dermatosis (CGDCGD). Clin Genet 23:276–280
Chitnis S, Monteiro J, Glass D et al (2000) The role of X-chromosome inactivation in female predisposition to autoimmunity. Arthritis Res 2:1–8
Özbalkan Z, Baǧışlar S, Kiraz S et al (2005) Skewed X chromosome inactivation in blood cells of women with scleroderma. Arthritis Rheum 52:1564–1570
Sybert VP, McCauley E (2004) Turner’s syndrome. N Engl J Med 351:1227–1238
Invernizzi P, Miozzo M, Battezzati PM et al (2004) Frequency of monosomy X in women with primary biliary cirrhosis. Lancet 363:533–535
Case LK, Wall EH, Dragon JA et al (2013) The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease. Genome Res 23:1474–1485
Dosiou C, Hamilton AE, Pang Y et al (2008) Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J Endocrinol 196:67–77
Miyaura H, Iwata M (2002) Direct and indirect inhibition of Th1 development by progesterone and glucocorticoids. J Immunol 168:1087–1094
Østensen M (1999) Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann N Y Acad Sci 876:131–144
Costenbader KH, Feskanich D, Stampfer MJ, Karlson EW (2007) Reproductive and menopausal factors and risk of systemic lupus erythematosus in women. Arthritis Rheum 56:1251–1262
Asscheman H, Giltay EJ, Megens JAJ et al (2011) A long-term follow-up study of mortality in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol 164:635–642
Cooper GS, Parks CG, Treadwell EL et al (2004) Occupational risk factors for the development of systemic lupus erythematosus. J Rheumatol 31:1928–1933
Koçar IH, Yesilova Z, Özata M et al (2000) The effect of testosterone replacement treatment on immunological features of patients with Klinefelter’s syndrome. Clin Exp Immunol 121:448–452
Zuk M (1990) Reproductive strategies and disease susceptibility: an evolutionary viewpoint. Parasitol Today 6:231–233
WHO (2011) Taking sex and gender into account in emerging infection disease programmes: an analytical framework. www.wpro.who.int/topics/gender_issues/Takingsexandgenderintoaccount.pdf. Zugegriffen 10.07.2014
Fish EN (2008) The X-files in immunity: sex-based differences predispose immune responses. Nat Rev Immunol 8:737–744
Markle JGM, Frank DN, Mortin-Toth S et al (2013) Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science 339:1084–1088
Yatsunenko T, Rey FE, Manary MJ et al (2012) Human gut microbiome viewed across age and geography. Nature 486:222–227
Yurkovetskiy L, Burrows M, Khan AA et al (2013) Gender bias in autoimmunity is influenced by microbiota. Immunity 39:400–412
Olszak T, An D, Zeissig S et al (2012) Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336:489–493
Adams Waldorf KM, Nelson JL (2008) Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy. Immunol Invest 37:631–644
Walsh JP, Bremner AP, Bulsara MK et al (2005) Parity and the risk of autoimmune thyroid disease: a community-based study. J Clin Endocrinol Metab 90:5309–5312
Miyashita Y, Ono M, Ono M et al (2000) Y chromosome microchimerism in rheumatic autoimmune disease. Ann Rheum Dis 59:654–656
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Interessenkonflikt. G. Riemekasten und E. Siegert geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.
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Riemekasten, G., Siegert, E. Geschlechtsspezifische Unterschiede des Immunsystems. Z. Rheumatol. 73, 600–606 (2014). https://doi.org/10.1007/s00393-014-1357-4
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DOI: https://doi.org/10.1007/s00393-014-1357-4