Skip to main content

Advertisement

SpringerLink
Log in

Sind die Empfehlungen zum Tuberkulosescreening noch zeitgemäß?

Interferon-γ-Release-Assay-Test und/oder Tuberkulinhauttest zur Diagnostik einer latenten Tuberkuloseinfektion

Are the recommendations on tuberculosis screening still valid?

Interferon gamma release assay (IGRA) and/or tuberculin skin test for diagnosis of latent tuberculosis infection (LTBI)

  • Hot Topics
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Meyer-Olson D, Hoeper K, Schmidt RE (2010) Infectious complications of biologic therapy in patients with rheumatoid arthritis. Z Rheumatol 69(10):879–888

    Article  PubMed  CAS  Google Scholar 

  2. WHO (2012) Global tuberculosis report 2012. http://apps.who.int/tb

  3. Ernst D, Bange FC, Rana A et al (2010) Reactivation of tuberculosis with Mycobacterium bovis infection of the oral mucosa during immunosuppression. Dtsch Med Wochenschr 135(23):1179–1181

    Article  PubMed  CAS  Google Scholar 

  4. Winthrop K, Baxter R, Liu L et al (2013) Mycobacterial diseases and antitumour necrosis factor therapy in USA. Ann Rheum Dis 72(1):37–42

    Article  PubMed  CAS  Google Scholar 

  5. Tubach F, Salmon D, Ravaud P et al (2009) Risk of tuberculosis is higher with anti-tumor necrosis factor monoclonal antibody therapy than with soluble tumor necrosis factor receptor therapy: the three-year prospective French Research Axed on Tolerance of Biotherapies registry. Arthritis Rheum 60(7):1884–1894

    Article  PubMed  CAS  Google Scholar 

  6. Denis B, Lefort A, Flipo RM et al (2008) Long-term follow-up of patients with tuberculosis as a complication of tumour necrosis factor (TNF)-alpha antagonist therapy: safe re-initiation of TNF-alpha blockers after appropriate anti-tuberculous treatment. Clin Microbiol Infect 14(2):183–186

    Article  PubMed  CAS  Google Scholar 

  7. Carmona L, Gomez-Reino JJ, Rodriguez-Valverde V et al (2005) Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists. Arthritis Rheum 52(6):1766–1772

    Article  PubMed  CAS  Google Scholar 

  8. Zwerling A, Behr MA, Verma A et al (2011) The BCG World Atlas: a database of global BCG vaccination policies and practices. PLoS Med 8(3):e1001012

    Article  PubMed  Google Scholar 

  9. Diel R, Goletti D, Ferrara G et al (2011) Interferon-gamma release assays for the diagnosis of latent Mycobacterium tuberculosis infection: a systematic review and meta-analysis. Eur Respir J 37(1):88–99

    Article  PubMed  CAS  Google Scholar 

  10. Pai M, Zwerling A, Menzies D (2008) Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Ann Intern Med 149(3):177–184

    Article  PubMed  Google Scholar 

  11. Hsia EC, Cush JJ, Matteson EL et al (2013) A comprehensive tuberculosis screening program in patients with inflammatory arthritides treated with golimumab, a human anti-TNF antibody, in phase 3 clinical trials. Arthritis Care Res 65(2):309–313

    Article  CAS  Google Scholar 

  12. Diel R, Hauer B, Loddenkemper R et al (2009) Recommendations for tuberculosis screening before initiation of TNF-alpha-inhibitor treatment in rheumatic diseases. Z Rheumatol 68(5):411–416

    Article  PubMed  CAS  Google Scholar 

  13. Belard E, Semb S, Ruhwald M et al (2011) Prednisolone treatment affects the performance of the QuantiFERON gold in-tube test and the tuberculin skin test in patients with autoimmune disorders screened for latent tuberculosis infection. Inflamm Bowel Dis 17(11):2340–2349

    Article  PubMed  Google Scholar 

  14. Hamdi H, Mariette X, Godot V et al (2006) Inhibition of anti-tuberculosis T-lymphocyte function with tumour necrosis factor antagonists. Arthritis Res Ther 8(4):R114

    Article  PubMed  Google Scholar 

  15. Matulis G, Juni P, Villiger PM, Gadola SD (2008) Detection of latent tuberculosis in immunosuppressed patients with autoimmune diseases: performance of a Mycobacterium tuberculosis antigen-specific interferon gamma assay. Ann Rheum Dis 67(1):84–90

    Article  PubMed  CAS  Google Scholar 

  16. Del Tedesco E, Roblin X, Laharie D, Peyrin Biroulet L (2011) Does anti-TNF therapy influence the performance of Mycobacterium tuberculosis antigen-specific interferon-gamma assays? A French multicenter experience. Inflamm Bowel Dis 17(8):1824

    Article  Google Scholar 

  17. Kleinert S, Tony HP, Krueger K et al (2012) Screening for latent tuberculosis infection: performance of tuberculin skin test and interferon-gamma release assays under real-life conditions. Ann Rheum Dis 71(11):1791–1795

    Article  PubMed  CAS  Google Scholar 

  18. Mariette X, Baron G, Tubach F et al (2012) Influence of replacing tuberculin skin test with ex vivo interferon gamma release assays on decision to administer prophylactic antituberculosis antibiotics before anti-TNF therapy. Ann Rheum Dis 71(11):1783–1790

    Article  PubMed  CAS  Google Scholar 

  19. Ponce de Leon D, Acevedo-Vasquez E, Alvizuri S et al (2008) Comparison of an interferon-gamma assay with tuberculin skin testing for detection of tuberculosis (TB) infection in patients with rheumatoid arthritis in a TB-endemic population. J Rheumatol 35(5):776–781

    Google Scholar 

  20. Mrozek N, Pereira B, Soubrier M et al (2012) Screening of tuberculosis before biologics. Med Mal Infect 42(1):1–4

    Article  PubMed  CAS  Google Scholar 

  21. Hsia EC, Schluger N, Cush JJ et al (2012) Interferon-gamma release assay versus tuberculin skin test prior to treatment with golimumab, a human anti-tumor necrosis factor antibody, in patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis. Arthritis Rheum 64(7):2068–2077

    Article  PubMed  CAS  Google Scholar 

  22. Gomez-Reino JJ, Carmona L, Angel Descalzo M (2007) Risk of tuberculosis in patients treated with tumor necrosis factor antagonists due to incomplete prevention of reactivation of latent infection. Arthritis Rheum 57(5):756–761

    Article  PubMed  CAS  Google Scholar 

  23. Winthrop KL, Weinblatt ME, Daley CL (2012) You can’t always get what you want, but if you try sometimes (with two tests – TST and IGRA – for tuberculosis) you get what you need. Ann Rheum Dis 71(11):1757–1760

    Article  PubMed  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. Folgende Unterstützungen (Honorare für Beratertätigkeiten, Reisekostenunterstützungen, Vortragsgebühren und Forschungsförderung) durch pharmazeutische Unternehmen wurden von den Autoren angegeben: D. Ernst: Abbvie, Bristol-Myers Squibb, Chugai, GKS, Pfizer, Roche, UCB; R.E. Schmidt: Roche, Chugai, Abbot; T. Witte: Abbott, Aesku.Diagnostics, Berlin-Chemie Menarini, BMS, Chugai, CSL-Behring, GSK, Merck, MSD, Novartis, Octapharma, Pfizer, Phadia, Roche, UCB; D. Meyer-Olson: Abbvie/Abbott, Boehringer Ingelheim, Bristol-Myers Squibb, CSL-Behring, Chugai, Pfizer, Roche, UCB, MSD, Janssen und ViiV. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    D. Ernst, T. Witte & R.E. Schmidt

  2. Rheumatologie und Innere Medizin, m&i Fachklinik Bad Pyrmont, Auf der Schanze 3, 31812, Bad Pyrmont, Deutschland

    D. Meyer-Olson

Authors
  1. D. Ernst
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Witte
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R.E. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. Meyer-Olson
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. Meyer-Olson.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ernst, D., Witte, T., Schmidt, R. et al. Sind die Empfehlungen zum Tuberkulosescreening noch zeitgemäß?. Z. Rheumatol. 72, 846–850 (2013). https://doi.org/10.1007/s00393-013-1169-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-013-1169-y

Search

Navigation