Skip to main content

Advertisement

SpringerLink
Log in

Epigenetische Analysen – neue Ansätze für die Therapie rheumatischer Erkrankungen?

Epigenetic analyses – new therapeutic approaches for rheumatic diseases?

  • Neues aus der Forschung
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1

Literatur

  1. Ballestar E (2011) Epigenetic alterations in autoimmune rheumatic diseases. Nat Rev Rheumatol 7:263–271

    Article  PubMed  CAS  Google Scholar 

  2. Belcaro G, Cesarone MR, Dugall M et al (2010) Efficacy and safety of Meriva(R), a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients. Altern Med Rev 15:337–344

    PubMed  Google Scholar 

  3. Branco MR, Ficz G, Reik W (2012) Uncovering the role of 5-hydroxymethylcytosine in the epigenome. Nat Rev Genet 13:7–13

    CAS  Google Scholar 

  4. Chandran B, Goel A (2012) A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res 26:1719–1725

    Article  PubMed  CAS  Google Scholar 

  5. Clayton AL, Hazzalin CA, Mahadevan LC (2006) Enhanced histone acetylation and transcription: a dynamic perspective. Molecular cell 23:289–296

    Article  PubMed  CAS  Google Scholar 

  6. De Groote ML, Verschure PJ, Rots MG (2012) Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes. Nucleic Acids Res 40(21):10596–10613

    Article  Google Scholar 

  7. Gray SG (2013) Perspectives on epigenetic-based immune intervention for rheumatic diseases. Arthritis Res Ther 15:207

    Article  PubMed  Google Scholar 

  8. Hu N, Qiu X, Luo Y et al (2008) Abnormal histone modification patterns in lupus CD4+ T cells. J Rheumatol 35:804–810

    PubMed  CAS  Google Scholar 

  9. Huehn J, Polansky JK, Hamann A (2009) Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol 9:83–89

    Article  PubMed  CAS  Google Scholar 

  10. Jeffries MA, Dozmorov M, Tang Y et al (2011) Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics 6:593–601

    Article  PubMed  CAS  Google Scholar 

  11. Nakano K, Whitaker JW, Boyle DL et al (2013) DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis 72:110–117

    Article  PubMed  CAS  Google Scholar 

  12. Quintero-Ronderos P, Montoya-Ortiz G (2012) Epigenetics and autoimmune diseases. Autoimmune Dis 2012:593720

    PubMed  Google Scholar 

  13. Richardson B, Scheinbart L, Strahler J et al (1990) Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis. Arthritis Rheum 33:1665–1673

    Article  PubMed  CAS  Google Scholar 

  14. Vojinovic J, Damjanov N, D’urzo C et al (2011) Safety and efficacy of an oral histone deacetylase inhibitor in systemic-onset juvenile idiopathic arthritis. Arthritis Rheum 63:1452–1458

    Article  PubMed  CAS  Google Scholar 

  15. Weng NP, Araki Y, Subedi K (2012) The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation. Nat Rev Immunol 12:306–315

    Article  PubMed  CAS  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Polansky, U. Syrbe und A. Hamann geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Experimentelle Rheumatologie, Deutsches Rheuma-Forschungszentrum, Charitéplatz 1, 10117, Berlin, Deutschland

    J.K. Polansky & A. Hamann

  2. Med. Klinik I, Rheumatologie, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Berlin, Deutschland

    U. Syrbe

Authors
  1. J.K. Polansky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. U. Syrbe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Hamann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J.K. Polansky.

Additional information

Anmerkung der Autoren: Wir möchten uns bei Kollegen entschuldigen, deren Arbeiten aus Platzgründen nicht zitiert werden konnten.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Polansky, J., Syrbe, U. & Hamann, A. Epigenetische Analysen – neue Ansätze für die Therapie rheumatischer Erkrankungen?. Z. Rheumatol. 72, 804–808 (2013). https://doi.org/10.1007/s00393-012-1121-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-012-1121-6

Search

Navigation