Skip to main content
SpringerLink
Log in

Empfehlungen für die Behandlung der ankylosierenden Spondylitis gemäß ASAS/EULAR

Evaluation der Updates von 2010 im deutschsprachigen Raum

ASAS/EULAR recommendations for the management of ankylosing spondylitis

Evaluation of the 2010 update in the German-speaking area

Zeitschrift für Rheumatologie volume 72, pages 71–80 (2013)Cite this article

Zusammenfassung

Die ASAS/EULAR-Empfehlungen für die Behandlung der ankylosierenden Spondylitis sind im Jahr 2010 überarbeitet worden. Aufgrund des Expertenkonsens und der Evidenzlage wurden die ursprünglichen 10 Empfehlungen auf 11 Empfehlungen erweitert und zusätzlich eine Rubrik „übergeordnete Prinzipien“ eingeführt, in der grundlegende Aspekte der Erkrankung angesprochen werden. Im vorliegenden Bericht werden die Ergebnisse der Evaluation der deutschen Übersetzung dieser Empfehlungen vorgestellt. Insgesamt 25 Experten aus Deutschland, Österreich und der Schweiz haben die Übersetzung hinsichtlich des Grades der Empfehlung auf einer Skala zwischen 0 (keine Übereinstimmung) bis 10 (volle Übereinstimmung) bewertet. Die Übereinstimmung der Experten mit den Empfehlungen war insgesamt mit 9,6 ± 1,05 sehr hoch.

Abstract

The ASAS/EULAR recommendations for the management of ankylosing spondylitis have been updated in 2010. The recommendations have been extended from 10 to 11 recommendations and 4 superior principles have been introduced based on the level of evidence and expert knowledge. The recommendations have been translated into German and have been evaluated by 25 experts from Germany, Austria and Switzerland. The experts scored the strength of the recommendations (SOR) on an 11 point numerical rating scale (from 0 = no agreement to 10 = total agreement). With a mean score of 9.6 ± 1.05 the SOR was generally very good.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

USD 39.95

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Abb. 1

Notes

  1. ASAS Core Set: van der Heijde D et al. J Rheumatol 1997;24:2225–2229 [20].

Abbreviations

AxSpA:

Axiale Spondyloarthritiden

AS:

Ankylosierende Spondylitis

ASAS:

Assessment of SpondyloArthritis International Society

BASFI:

Bath Ankylosing Spondylitis Functional Index

CED:

Chronisch entzündliche Darmerkrankung

EULAR:

European League against Rheumatism

ICF:

Internationale Klassifikation für Funktionsfähigkeit, Behinderung und Gesundheit

nr-axSpA:

Nichtröntgenologische axiale Spondyloarthritiden

SIG:

Sakroiliakalgelenke

SpA:

Spondyloarthritiden

SLR:

Systematische Literatursuche

TNF:

Tumornekrosefaktor

Literatur

  1. Zochling JJ, Heijde D van der, Burgos-Vargas R et al (2006) ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 65:442–452

    Article  PubMed  CAS  Google Scholar 

  2. Zochling JJ, Heijde D van der, Dougados M et al (2006) Current evidence for the management of ankylosing spondylitis: a systematic literature review for the ASAS/EULAR management recommendations in ankylosing spondylitis. Ann Rheum Dis 65:423–432

    Article  PubMed  CAS  Google Scholar 

  3. Braun J, van den Berg R, Baraliakos X et al (2011) Update 2010 of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Ann Rheum Dis 70:896–904

    Article  PubMed  CAS  Google Scholar 

  4. Berg R van den, Baraliakos X, Braun J et al (2012) First update of the current evidence for the management of ankylosing spondylitis with non-pharmacological treatment and non-biologic drugs: a systematic literature review for the ASAS/EULAR management recommendations in ankylosing spondylitis. J Rheumatol 51:1388–1396

    Article  Google Scholar 

  5. Kiltz U van der, Heijde D, Mielants H et al (2009) ASAS/EULAR recommendations for the management of ankylosing spondylitis: the patient version. Ann Rheum Dis 68:1381–1386

    Article  PubMed  CAS  Google Scholar 

  6. Kiltz U, Feldtkeller E, Braun J (2010) German patient version of the ASAS/EULAR recommendations for the management of ankylosing spondylitis. Z Rheumatol 69:171–174, 176–179

    Article  PubMed  CAS  Google Scholar 

  7. Braun J, Sieper J (2009) Disseminierung und Evaluation der ASAS/EULAR Empfehlung für das Management der Spondylitis ankylosans in Europa. Z Rheumatol 68:417–419

    Article  PubMed  CAS  Google Scholar 

  8. Braun J, Zochling J, Märker-Hermann E et al (2006) Empfehlungen für das Management der ankylosierenden Spodylitis gemäß ASAS/EULAR. Evaluation im deutschsprachigen Raum. Z Rheumatol 65:728–742

    Article  PubMed  CAS  Google Scholar 

  9. Kiltz U, Feldtkeller E, Braun J (2008) Deutsche Patientenversion der Empfehlungen für das Management des Morbus Bechterew gemäß ASAS/EULAR. Z Rheumatol 67:694–700

    Article  PubMed  CAS  Google Scholar 

  10. Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379–1390

    Article  PubMed  Google Scholar 

  11. Rudwaleit Landewé R, Heijde D van der et al (2009) The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part I): classification of paper patients by expert opinion including uncertainty appraisal. Ann Rheum Dis 68:770–776

    Article  PubMed  CAS  Google Scholar 

  12. Rudwaleit M, Heijde D van der, Landewé R et al (2009) The development of assessment of spondyloarthritis international society classification criteria for axial spondyloarthritis (part II): validation and final selection. Ann Rheum Dis 68:777–783

    Article  PubMed  CAS  Google Scholar 

  13. Rudwaleit M, Jurik AG, Hermann KG et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI Group. Ann Rheum Dis 68:1520–1527

    Article  PubMed  CAS  Google Scholar 

  14. Sieper Rudwaleit M, Baraliakos X et al (2009) The assessment of spondyloarthritis international society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 68(Suppl 2):ii1–44

    Article  PubMed  Google Scholar 

  15. Rudwaleit M, Haibel H, Baraliakos X et al (2009) The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheum 60:717–727

    Article  PubMed  CAS  Google Scholar 

  16. Kiltz U, Baraliakos X, Karakostas P et al (2012) Patients with non-radiographic axial spondyloarthritis differ from patients with ankylosing spondylitis in several aspects. Arthritis Care Res 64:1415–1422

    Article  Google Scholar 

  17. WHO (2001) Internationale Klassifikation der Funktionsfähigkeit, Behinderung und Gesundheit. Welt-Gesundheitsorganisation, Genf

  18. Boonen Braun J, Horst-Bruinsma IE van der et al (2010) The ASAS/WHO ICF core sets for ankylosing spondylitis: how to classify the impact of AS on functioning and health. Ann Rheum Dis 69:102–107

    Article  PubMed  CAS  Google Scholar 

  19. Wanders A, Heijde D van der, Landewé R et al (2005) Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 52:1756–1765

    Article  PubMed  CAS  Google Scholar 

  20. Heijde D van der, Bellamy N, Calin A et al (1997) Preliminary core sets for endpoints in ankylosing spondylitis. Assessments in Ankylosing Spondylitis Working Group. J Rheumatol 24:2225–2229

    PubMed  Google Scholar 

  21. Dagfinrud H, Kvien TK, Hagen KB (2008) Physiotherapy interventions for ankylosing spondylitis. Cochrane Database Syst Rev 1:CD002822

    PubMed  Google Scholar 

  22. Vosse D, Landewé R, Heijde D van der et al (2009) Ankylosing spondylitis and the risk of fracture: results from a large primary care-based nested case – control study. Ann Rheum Dis 68:1839–1842

    Article  PubMed  CAS  Google Scholar 

  23. Peters MJ, Eijk IC van, Smulders YM et al (2010) Signs of accelerated preclinical atherosclerosis in patients with ankylosing spondylitis. J Rheumatol 37:161–166

    Article  PubMed  Google Scholar 

  24. Peters MJ, Symmons DP, McCarey D et al (2010) EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis 69:325–331

    Article  PubMed  CAS  Google Scholar 

  25. Braun J, Zochling J, Baraliakos X et al (2006) Efficacy of sulfasalazine in patients with inflammatory back pain due to undifferentiated spondyloarthritis and early ankylosing spondylitis: a multicentre randomised controlled trial. Ann Rheum Dis 65:1147–1153

    Article  PubMed  CAS  Google Scholar 

  26. Braun J, Horst-Bruinsma IE van der, Huang F et al (2011) Clinical efficacy and safety of etanercept versus sulfasalazine in ankylosing spondylitis patients: a randomized, double-blind study (ASCEND Trial). Arthritis Rheum 63:1543–1551

    Article  PubMed  CAS  Google Scholar 

  27. Song IH, Hermann, Haibel H et al (2011) Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial. Ann Rheum Dis 70:590–596

    Article  PubMed  CAS  Google Scholar 

  28. Chen J, Liu C, Lin J (2006) Methotrexate for ankylosing spondylitis. Cochrane Database Syst Rev 4:CD004524

    PubMed  Google Scholar 

  29. Haibel H, Brandt HC, Song IH et al (2007) No efficacy of subcutaneous methotrexate in active ankylosing spondylitis: a 16-week open-label trial. Ann Rheum Dis 66:419–421

    Article  PubMed  CAS  Google Scholar 

  30. Heijde D van der, Sieper J, Maksymowych H et al (2011) 2010 Update of the international ASAS recommendations for the sue of anti-TNF-agents in patients with axial spondyloarthritis. Ann Rheum Dis 70:905–908

    Article  PubMed  Google Scholar 

  31. Colina M, Ciancio G, Garavini R et al (2009) Combination treatment with etanercept and an intensive spa rehabilitation program in active ankylosing spondylitis. Int J Immunopathol Pharmacol 22:1125–1129

    PubMed  CAS  Google Scholar 

  32. Westerveld LA, Verlaan JJ, Oner FC (2009) Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications. Eur Spine J 18:145–156

    Article  PubMed  CAS  Google Scholar 

  33. Sochardt DH, Porter ML (1997) Long-term results of total hip replacement in young patients who had ankylosing spondylitis. Eighteen to thirty-year results with survivorship analysis. J Bone Joint Surg Am 79:1181–1189

    Google Scholar 

  34. Bhan S, Eachempati KK, Malhotra R (2008) Primary cementless total hip arthroplasty for bony ankylosis in patients with ankylosing spondylitis. J Arthroplasty 23:859–866

    Article  PubMed  Google Scholar 

Download references

Danksagung

Xenofon Baraliakos, Beat Michel, Heinrich Böhm, Jan Brandt, Cem Gabay, Winfried Graininger, Michael Hammer, Kirsten Karberg, Herbert Kellner, Lars Köhler, Klaus Krüger, Jens Kuipers, Heinz-Jürgen Lakomek, Burkhard Leeb, Elisabeth Märker-Hermann, Bernhard Manger, Wilfried Mau, Denis Poddubnyy, Stefan Rehart, Martin Rudwaleit, Michael Schirmer, In-Ho Song, Peter Villiger, Ueli Weber, Jürgen Wollenhaupt.

Interessenkonflikt

Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

  1. Rheumazentrum Ruhrgebiet, Landgrafenstr. 15, 44652, Herne, Deutschland

    U. Kiltz & J. Braun

  2. Charite Berlin, Campus Benjamin Franklin, Berlin, Deutschland

    J. Sieper

Authors
  1. U. Kiltz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. Sieper
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Braun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to U. Kiltz.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Kiltz, U., Sieper, J. & Braun, J. Empfehlungen für die Behandlung der ankylosierenden Spondylitis gemäß ASAS/EULAR. Z. Rheumatol. 72, 71–80 (2013). https://doi.org/10.1007/s00393-012-1071-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00393-012-1071-z

Schlüsselwörter

Keywords

search

Navigation