Abstract
The aim of this study was to estimate the serum concentration of carbohydrate-deficient transferrin (CDT) in patients with rheumatoid arthritis (RA) and the relationship between the CDT level and disease activity in RA patients. Studies were carried out in 47 female patients with RA and 32 healthy women. Disease activity of RA was evaluated using the 28-joint count Disease Activity Score (DAS 28). Serum CDT was determined by particle-enhanced immunononephelometry using the N Latex CDT test. Patients with RA had significantly lower serum concentrations of CDT compared with controls. The correlation study showed the significant negative relationship between CDT and DAS 28 (r = − 0.483, p = 0.011). There were no correlations between serum CDT level and patient’s age, disease duration, number of tender and swollen joints, and degree of disability evaluated by the Health Assessment Questionnaire. The level of CDT in patients with RA was significantly decreased and confirms the changes in transferrin glycosylation which are dependent on the disease activity. Therefore, measurement of CDT in the sera of patients with RA can be useful for the evaluation of disease activity in these patients.
Zusammenfassung
Ziel der Studie war es, die Serumkonzentration von Carbohydrate-Deficient Transferrin (CDT) bei Patienten mit rheumatoider Arthritis (RA) und den Zusammenhang zwischen dem CDT-Spiegel und der Krankheitsaktivität bei RA-Patienten zu ermitteln. Studienteilnehmer waren 47 Patientinnen mit RA und 32 gesunde Frauen. Die Krankheitsaktivität wurde anhand des auf 28 Gelenke bezogenen Disease Activity Score (DAS 28) bestimmt. Das Serum-CDT wurde durch partikelverstärkte Immunnephelometrie mit dem N-Latex-CDT-Test gemessen. Die RA-Patientinnen wiesen signifikant niedrigere Serumkonzentrationen von CDT als die Kontrollen auf. Die Korrelationsstudie zeigte die signifikante negative Beziehung zwischen CDT und Krankheitsaktivitätswert (DAS 28; r = − 0,483; p = 0,011). Es gab keine Korrelation zwischen dem Serum-CDT-Spiegel und dem Patientenalter, der Krankheitsdauer, der Anzahl der empfindlichen und geschwollenen Gelenke sowie dem Grad der Behinderung gemäß Health Assessment Questionnaire. Der CDT-Spiegel bei RA-Patienten war signifikant vermindert und bestätigt Veränderungen bei der Transferrin-Glykosylierung, die von der Krankheitsaktivität abhängig sind. Daher können Messungen des CDT im Serum von RA-Patienten zur Beurteilung der Krankheitsaktivität sinnvoll sein.
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Cylwik, B., Chludzinska, A., Chrostek, L. et al. Relationship between CDT and disease activity in rheumatoid arthritis. Z. Rheumatol. 71, 220–223 (2012). https://doi.org/10.1007/s00393-011-0853-z
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DOI: https://doi.org/10.1007/s00393-011-0853-z
Keywords
- Carbohydrate-deficient transferrin
- Rheumatoid arthritis
- Disease activity score
- Severity of illness index