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Familiäre Häufung, genetische Wurzeln und Erkenntniszugewinn in der Pathogenese von Autoimmunerkrankungen

Familial clustering, genetic roots and insights into the pathogenesis of autoimmune diseases

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Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Genomweite Screening-Studien haben zu einem rasanten Erkenntniszuwachs über genetische Ursachen von Autoimmunerkrankungen geführt. Die identifizierten Gene sind Indikatoren für pathogenetisch relevante Signalwege und können zur Identifizierung therapeutischer Angriffspunkte beitragen.

Abstract

Genome-wide association studies have dramatically increased our knowledge about the genetic contribution to autoimmune diseases. The identified genes are indicators for signal transduction pathways involved in disease pathogenesis and could contribute to potential new therapeutic approaches.

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  1. Medizinische Klinik II, Sektion Rheumatologie, Universität Leipzig, Liebigstr. 22, 04103, Leipzig, Deutschland

    M. Pierer, C. Baerwald &  U. Wagner

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  1. M. Pierer
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  2. C. Baerwald
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  3. U. Wagner
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Correspondence to U. Wagner.

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Pierer, M., Baerwald, C. & Wagner, U. Familiäre Häufung, genetische Wurzeln und Erkenntniszugewinn in der Pathogenese von Autoimmunerkrankungen. Z. Rheumatol. 68, 758–762 (2009). https://doi.org/10.1007/s00393-009-0556-x

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  • DOI: https://doi.org/10.1007/s00393-009-0556-x

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