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Interleukin-1-Zytokine, Inflammasome, NOD-Signalosome und Autoinflammation

Interleukin-1 cytokines, inflammasomes, NOD-signalosomes and autoinflammation

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Zusammenfassung

Die Erforschung der Grundlagen hereditärer autoinflammatorischer Syndrome hat große Bedeutung erlangt für das Verständnis und die Therapie von erworbenen IL-1β-assoziierten nichtinfektiösen Entzündungskrankheiten. Im Fokus des Interesses befinden sich makromolekulare zytosolische Komplexe zur Synthese und Aktivierung von Zytokinen der IL-1-Familie: NOD-Signalosome und Inflammasome.

Abstract

The understanding of the genetic and immunological basis of human periodic fever syndromes, in particular cryopyrin-associated periodic syndromes (CAPS), has led to important new insights into the pathogenesis of monogenic and complex interleukin-1beta-associated autoinflammatory diseases. Currently the focus of attention is on the nucleotide-binding oligomerization domain (NOD)-like receptors (NLR), which take part in the regulation of the synthesis and maturation of cytokines in the IL-1 families, NOD-signalosomes and inflammasomes.

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Abbreviations

ASC:

„Apoptosis-associated speck-like protein“

ATP:

Adenosintriphosphat

BIR:

„Baculovirus inhibitor of apoptosis protein repeat“

CIITA:

„Major histocompatibility complex (MHC) class II transactivator“

CAPS:

Cryopyrin-assoziiertes periodisches Fiebersyndrom

CARD:

Caspasen-rekrutierende Domäne

CINCA:

„Chronic infantile neurologic cutaneous and articular syndrome“

FCAS:

„Familial cold autoinflammatory syndrome“

FMF:

Familiäres Mittelmeerfieber

IL:

Interleukin

IPAF:

„ICE-protease activating factor“

JNK:

Januskinase

MWS:

Muckle-Wells-Syndrom

NOD:

Nukleotid-bindende Oligomerisierungsdomäne

NLR:

„NOD-like receptor“

NACHT:

Domäne, welche von NAIP, CIITA, HET-E, TP-1 verwendet wird

NAIP:

Neuronales Apoptose-inhibitorisches Protein

NALP:

NACHT-LRR-PYD-enthaltendes Protein

NOMID:

„Neonatal-onset multisystem inflammatory disease“

PAPA:

„Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome“

PRR:

„Pattern-recognition receptor“ (Mustererkennungsrezeptor)

PrySpry:

„Pry (PTPN13-related protein, Y-linked) and SpIA ryanodine receptor (RyR)-like“

PSTPIP1:

Prolin-Serin-Threonin-Phosphatasen-interagierendes Protein 1

PYD:

Pyrindomäne

RIP2:

Rezeptor-interagierendes Protein 2

SAPHO:

Synovitis, Akne, Pustulose, Hyperostose und Osteitis (Syndrom)

ST2:

„Signal transduction 2 protein“

TH:

T-Helfer-Zelltyp

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  1. Division of Infection, Inflammation & Immunity, Southampton General Hospital, School of Medicine, University of Southampton, UK, MP811 Tremona Road, SO16 6YD, Southampton, Großbritannien

    S.D. Gadola

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Gadola, S. Interleukin-1-Zytokine, Inflammasome, NOD-Signalosome und Autoinflammation. Z. Rheumatol. 68, 712–719 (2009). https://doi.org/10.1007/s00393-009-0488-5

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