Advertisement

Zeitschrift für Rheumatologie

, Volume 68, Issue 5, pp 405–408 | Cite as

Th17-Zellen – eine neue proinflammatorische T-Zell-Population und ihre Bedeutung für rheumatologische Autoimmunerkrankungen

  • J. LeipeEmail author
  • A. Skapenko
  • H. Schulze-Koops
Neues aus der Forschung

Zusammenfassung

In der Entstehung und Aufrechterhaltung von autoimmunen rheumatologischen Erkrankungen spielen CD4-T-Zellen eine wesentliche Rolle. Die kürzliche Entdeckung von Interleukin- (IL-)17-produzierenden Th17-Zellen als potente proinflammatorische T-Zell-Population erweitert das Verständnis pathophysiologischer Vorgänge, die zuvor nicht durch die Th1/Th2-Dichotomie erklärt werden konnten. Die in diesem Artikel diskutierten aktuellen Daten aus humanen Studien deuten auf eine wichtige pathogenetische Funktion von Th17-Zellen und dem von ihnen produzierten IL-17 bei zahlreichen rheumatologischen Erkrankungen hin, sodass auf Th17-Zellen/IL-17-zielende Therapien von potenziellem Nutzen in der Behandlung dieser Erkrankungen sein könnten.

Schlüsselwörter

T-Zellen Th17 IL-17 Arthritis Rheumatologische Erkrankungen 

Th17 cells – a new proinflammatory T cell population and its role in rheumatologic autoimmune diseases

Abstract

CD4 T cells play a major role in the development and persistence of autoimmune rheumatic diseases. The recent identification of IL-17-producing Th17 cells as a potent proinflammatory subset extends the understanding of pathophysiological processes not explained by the Th1/Th2 dichotomy. The recent data from human studies discussed in this article indicate an important pathogenic function for Th17 cells and Th17-derived IL-17 suggesting that therapies targeting Th17 cells/IL-17 may be of potential use in the treatment of those diseases.

Keywords

T cells Th17 IL-17 Arthritis Rheumatic disease 

Notes

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Literatur

  1. 1.
    Agarwal S, Misra R, Aggarwal A (2008) Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol 35:515–519PubMedGoogle Scholar
  2. 2.
    Cai L, Yin J, Starovasnik M et al (2001) Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo. Cytokine 16:10–21PubMedCrossRefGoogle Scholar
  3. 3.
    Chabaud M, Durand J, Buchs N et al (1999) Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum 42:963–970PubMedCrossRefGoogle Scholar
  4. 4.
    Chabaud M, Lubberts E, Joosten L et al (2001) IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis. Arthritis Res Ther 3:168–177Google Scholar
  5. 5.
    Codolo G, Amedei A, Steere A et al (2008) Borrelia burgdorferi NapA-driven Th17 cell inflammation in lyme arthritis. Arthritis Rheum 58:3609–3617PubMedCrossRefGoogle Scholar
  6. 6.
    Infante-Duarte C, Horton H, Byrne M et al (2000) Microbial lipopeptides induce the production of IL-17 in Th cells. J Immunol 165:6107–6115PubMedGoogle Scholar
  7. 7.
    Jandus C, Bioley G, Rivals J et al (2008) Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum 58:2307–2317PubMedCrossRefGoogle Scholar
  8. 8.
    Kirkham B, Lassere M, Edmonds J et al (2006) Synovial membrane cytokine expression is predictive of joint damage progression in rheumatoid arthritis: A two-year prospective study (the DAMAGE study cohort). Arthritis Rheum 54:1122–1131PubMedCrossRefGoogle Scholar
  9. 9.
    Kohno M, Tsutsumi A, Matsui H et al (2008) Interleukin-17 gene expression in patients with rheumatoid arthritis. Mod Rheumatol 18:15–22PubMedCrossRefGoogle Scholar
  10. 10.
    Kotake S, Udagawa N, Takahashi N et al (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest 103:1345–1352PubMedCrossRefGoogle Scholar
  11. 11.
    Kurasawa K, Hirose K, Sano H et al (2000) Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum 43:2455–2463PubMedCrossRefGoogle Scholar
  12. 12.
    Leipe S, Skapenko A, Schulze-Koops H (2008) Increased Th17 cell frequency and effector functions in patients with early rheumatoid and psoriatic arthritis. Arthritis Rheum 58 (Suppl):1253–1254Google Scholar
  13. 13.
    Lubberts E (2008) IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine 41:84–91PubMedCrossRefGoogle Scholar
  14. 14.
    Raza K, Falciani F, Curnow S et al (2005) Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 7:R784–795PubMedCrossRefGoogle Scholar
  15. 15.
    Singh R, Aggarwal A, Misra R (2007) Th1/Th17 cytokine profiles in patients with reactive arthritis/undifferentiated spondyloarthropathy. J Rheumatol 34:2285–2290PubMedGoogle Scholar
  16. 16.
    Tesmer L, Lundy S, Sarkar S et al (2008) Th17 cells in human disease. Immunol Rev 223:87–113PubMedCrossRefGoogle Scholar
  17. 17.
    Wendling D, Cedoz J, Racadot E et al (2007) Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 74:304–305PubMedCrossRefGoogle Scholar
  18. 18.
    Wong C, Lit L, Tam L et al (2008) Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity. Clin Immunol 127:385–393PubMedCrossRefGoogle Scholar
  19. 19.
    Yamada H, Nakashima Y, Okazaki K et al (2008) Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis 67:1299–1304PubMedCrossRefGoogle Scholar

Copyright information

© Springer Medizin Verlag 2009

Authors and Affiliations

  1. 1.Rheumaeinheit, Medizinische PoliklinikKlinikum der Universität MünchenMünchenDeutschland

Personalised recommendations