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Zur Bedeutung der Genvariante PTPN22 620W für die Rheumatologie

Relevance of the gene variant PTPN22 620W for rheumatology

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Zusammenfassung

PTPN22 620W gilt als zweitwichtigster genetischer Risikofaktor für Typ-1-Diabetes und rheumatoide Arthritis. Die Molekularbiologie des Enzyms, die geographische Verbreitung der Variante und ihre Bedeutung auch für seltenere rheumatische Erkrankungen werden beschrieben.

Abstract

PTPN22 620W is regarded as the second most important risk factor for type 1 diabetes and rheumatoid arthritis. Here we describe aspects of the molecular biology of the enzyme and its function, the geographical distribution of the 620W variant, as well as its importance in less frequent rheumatic diseases.

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Danksagung

Förderung: BMBF 01 GM 0310/0634.

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Authors and Affiliations

  1. Klinische Forschergruppe für Rheumatologie, Abteilung für Rheumatologie und Klinische Immunologie, Universitätsklinikum Freiburg, Breisacher Str. 66 (ZKF), 79106, Freiburg, Deutschland

    I. Melchers

  2. Institut für Medizinische Informatik, Statistik und Epidemiologie und Institut für Klinische Immunologie und Transfusionsmedizin, Biotechnologisch-Biomedizinisches Zentrum, Universität Leipzig, Leipzig, Deutschland

    P. Ahnert

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  1. I. Melchers
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  2. P. Ahnert
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Correspondence to I. Melchers.

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Melchers, I., Ahnert, P. Zur Bedeutung der Genvariante PTPN22 620W für die Rheumatologie. Z. Rheumatol. 67, 593–595 (2008). https://doi.org/10.1007/s00393-008-0381-7

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  • DOI: https://doi.org/10.1007/s00393-008-0381-7

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