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Labordiagnostik bei systemischer Sklerose

Laboratory diagnostics for systemic sclerosis

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Zusammenfassung

Laboranalysen können bei der systemischen Sklerose (SSc) klinische Untersuchungen, bildgebende Verfahren und funktionelle Tests punktuell ergänzen. Charakteristische Autoantikörper stützen die Frühdiagnose sowie die Zuordnung der Patienten zu Subsets der Erkrankung. Das Fehlen von antinukleären Antikörpern legt den Diagnoseausschluss nahe. Zur Erkennung von Organbeteiligungen und Komorbidität trägt das Labor vor allem durch verschiedene klinisch-chemische Analysen, mitunter auch histologische Verfahren sowie die zytologische Analyse der BAL-Flüssigkeit bei. Entzündungsparameter sind von untergeordneter Bedeutung. Vielfache Autoantikörperbestimmungen im Verlauf sind bislang nicht sinnvoll. Zahlreiche für die Pathogeneseforschung bedeutsame Laborparameter haben noch keinen Eingang in die Routinediagnostik der systemischen Sklerose gefunden.

Abstract

For systemic sclerosis, laboratory tests can play a supplementary role to clinical investigations, imaging techniques and functional tests. Typical autoantibodies support early diagnosis and help in assigning patients to subgroups of the disease; negative results for antinuclear antibodies suggest exclusion of the diagnosis. To detect organ involvement and comorbidity, the laboratory contributes by clinical chemistry, in certain cases by histopathological findings and by the cytological assessment of broncho-alveolar lavage fluid. Inflammatory parameters are of minor importance. Multiple autoantibody determinations in the course of the disease are not yet helpful. Numerous additional laboratory parameters are of value for investigating pathogenesis, but have not yet been generally introduced into the routine diagnostics of systemic sclerosis.

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Authors and Affiliations

  1. Labor an der Rheumaklinik Aachen, Burtscheider Markt 24, 52066, Aachen, Deutschland

    R. Mierau

  2. Klinik und Poliklinik für Dermatologie und Venerologie, Universität zu Köln, Köln, Deutschland

    A. Roers

  3. Rheumaklinik und Rheumaforschungsinstitut Aachen, Aachen, Deutschland

    E. Genth

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  1. R. Mierau
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  2. A. Roers
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  3. E. Genth
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Correspondence to R. Mierau.

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Mierau, R., Roers, A. & Genth, E. Labordiagnostik bei systemischer Sklerose. Z. Rheumatol. 66, 206–211 (2007). https://doi.org/10.1007/s00393-007-0156-6

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  • DOI: https://doi.org/10.1007/s00393-007-0156-6

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