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T-Zell-abhängige Monozytenaktivierung, TNFα und Apolipoprotein A-I in Autoimmunität und Inflammation

T cell-dependent monocyte activation, TNFα and apolipoprotein A-I in autoimmunity and inflammation

  • BEITRAG ZUM SCHWERPUNKTTHEMA
  • Published:
Zeitschrift für Rheumatologie Aims and scope Submit manuscript

Zusammenfassung

Die Rheumatoide Arthritis ist gekennzeichnet durch eine massive Produktion der Monokine TNFα, IL-6 und IL-1β in der Synovialmembran, wobei Monozyten und Makrophagen die Hauptproduzenten dieser Zytokine sind. Bisher ist noch unklar, wie es zu einer Aktivierung dieser Zellen kommt. Ein möglicher Mechanismus ist die zellkontaktabhängige Aktivierung der Monozyten/Makrophagen durch aktivierte T-Zellen. Der direkte Zellkontakt von Monozyten/Makrophagen und T-Zellen führt zu einer starken Produktion von proinflammatorischen Zytokinen, wie z. B. TNFα und IL-1β. Unter nicht-pathologischen Bedingungen muss dieser Mechanismus einer strengen Kontrolle unterliegen, um systemische inflammatorische Reaktionen zu vermeiden. Das Vorhandensein von inhibitorischen Faktoren im Serum könnte einen solchen Mechanismus repräsentieren. Im Serum von gesunden Spendern wurde Apolipoprotein A-I als ein solcher Faktor identifiziert. Apolipoprotein A-I ist als negatives Akut- Phase-Protein bei Patienten mit Rheumatoider Arthritis in deutlich verminderten Konzentrationen im Serum zu finden. Die Rolle dieses und ähnlicher inhibitorischer Serummoleküle bei Autoimmunerkrankung, Sepsis und Arteriosklerose wird diskutiert.

Summary

Rheumatoid arthritis is characterized by a massive overproduction of monokines like TNFα, IL-6 and IL-1β, which are predominantly produced by monocytes and macrophages. To date, the exact mechanisms of monocyte/macrophage activation have not been fully elucidated. One possible mechanism is their cell contact-dependent activation by activated T cells. The direct cell contact of monocytes/macrophages and T cells leads to an increased production of pro-inflammatory cytokines such as TNFα and IL-1β. Stringent control of this mechanism by inhibitory factors appears mandatory under physiological conditions in order to avoid systemic cytokine release syndromes. The presence of inhibitory factors in the serum could represent such a mechanism. In healthy donors, apolipoprotein A-I was identified as such an inhibitory serum protein. In patients with rheumatoid arthritis, apolipoprotein A-I is found in decreased concentrations, possibly due to its role as a negative acute phase protein. The role of this and other inhibitory serum molecules are discussed.

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  1. Medizinische Klinik und Poliklinik IV, Zentrum für Innere Medizin der Universität Leipzig, Liebigstr. 22, 04103, Leipzig, Germany

    M. Rossol, H. Häntzschel & U. Wagner

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  2. H. Häntzschel
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  3. U. Wagner
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Rossol, M., Häntzschel, H. & Wagner, U. T-Zell-abhängige Monozytenaktivierung, TNFα und Apolipoprotein A-I in Autoimmunität und Inflammation. Z. Rheumatol. 64, 249–254 (2005). https://doi.org/10.1007/s00393-005-0735-3

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  • DOI: https://doi.org/10.1007/s00393-005-0735-3

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