Skip to main content
Log in

Aktuelle Diagnostik und Therapie von Herzklappenerkrankungen

Current standard in diagnosis and therapy of heart valve lesions

  • Published:
Zeitschrift für Kardiologie Aims and scope Submit manuscript

Summary

We present a survey of the current standard in diagnosis and therapy of the most frequent heart valve lesions. During the last 50 years there has been a dramatic shift concerning the etiology of valve lesions with a rise of the agedependent degenerative towards rheumatic valve diseases. The aim of the diagnostic evaluation of valve lesions is primarily the clinical and hemodynamic grading of the severity of the valve disease, the recognition of relevant coexisting cardiac and extracardiac diseases and furthermore, an optimal timing of surgery in close correlation with the cardiac surgeons.

Zusammenfassung

Die vorliegende Arbeit soll einen Überblick über den aktuellen Standard der Diagnostik und der Therapie der häufigsten Herzklappenvitien geben. In den letzten 50 Jahren kam es zu einem beträchtlichen Umschwung bezüglich der Ätiologie der Klappenvitien mit einem signifikanten Anstieg der altersabhängigen degenerativen Klappenerkrankung bei gleichzeitiger Abnahme der Häufigkeit rheumatischer Klappenfehler. Ziel der Diagnostik von Herzklappenerkrankungen sind v.a. die Erfassung des klinischen und hämodynamischen Schweregrads sowie das Erkennen relevanter kardialer und extrakardialer Komorbiditäten, um ein möglichst optimales Timing des Operationszeitpunkts bei niedrigen peri- und postoperativen Risiken zu entwickeln. Alle diese Schritte sind letztendlich nur in enger Kooperation mit den Kardiochirurgen denkbar.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Literatur

  1. Bonow RO (1994) Management of chronic aortic regurgitation. N Engl J Med 331: 736

    Article  CAS  PubMed  Google Scholar 

  2. Bonow RO, Rosing DR, McIntosh CL et al. (1983) The natural history of asymptomatic patients with aortic regurgitation and normal left ventricular function. Circulation 68: 509

    Article  CAS  PubMed  Google Scholar 

  3. Bonow RO, Lakatos E, Maron BJ et al. (1991) Serial long term assessment of the natural history of asymptomatic patients with chronic aortic regurgitation and normal left ventricular function. Circulation 84: 1625–1635

    Article  CAS  PubMed  Google Scholar 

  4. Bonow RO, Carabello B, Leon de AC et al. (1998) Guidelines for the management of patients with valvular heart disease. ACC/AHA Practice Guidelines. Circulation 98: 1949–1984

    Article  CAS  PubMed  Google Scholar 

  5. Borer JS, Hochreiter C, Herrold EM et al. (1998) Prediction of indications for valve replacement among asymptomatic or minimally symptomatic patients with chronic aortic regurgitation and normal left ventricular performance. Circulation 97: 525–534

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  6. Borow KM, Marcus RH (1991) Aortic regurgitation: the need for an integrated physiologic approach (editorial). J Am Coll Cardiol 17: 898–900

    Article  CAS  PubMed  Google Scholar 

  7. Bruce CJ, Nishimura R (1998) New advances in diagnosis and treatment of mitral stenosis. Curr Probl Cardiol 23: 125–128

    Article  CAS  PubMed  Google Scholar 

  8. Burwash IG, Blackmore GL, Koilpillai CJ (1992) Usefulness of left atrial and left ventricular chamber sizes as predictors of the severity of mitral regurgitation. Am J Cardiol 70: 774–779

    Article  CAS  PubMed  Google Scholar 

  9. Carabello BA (1990) Aortic regurgitation: a lesion with similarities to both, aortic stenosis and mitral regurgitation. Circulation 82: 1051–1053

    Article  CAS  PubMed  Google Scholar 

  10. Dare AJ, Veinot JP, Edwards WD et al. (1993) New observations on the etiology of aortic valve disease: a surgical pathologic study of 236 cases from 1990. Hum Pathol 24: 1330–1338

    Article  CAS  PubMed  Google Scholar 

  11. Delahaye JP, Gare JP, Viguier E et al. (1991) Natural history of severe mitral regurgitation. Eur Heart J (Suppl B) 12: 5–9

    Article  PubMed  Google Scholar 

  12. Douglas PS, Berko B, Lesh M et al. (1989) Alterations in diastolic function in response to progressive left ventricular hypertrophy. J Am Coll Cardiol 13: 461–7

    Article  CAS  PubMed  Google Scholar 

  13. Duran J, Goldberg S (1986) Acute aortic regurgitation: pathophysiology and management. Cardiovasc Clin 16: 281–288

    Google Scholar 

  14. Enriques-Sarano M, Tajik AJ, Schaaf HV et al. (1994) Echocardiographic prediction of survival after surgical correction of organic mitral regurgitation. Circulation 90: 830–837

    Article  Google Scholar 

  15. Enriques-Sarano M, Tajik AJ, Schaaf HV et al. (1994) Echocardiographic prediction of left ventricular function after correction of mitral regurgitation: results and clinical implications. J Am Coll Cardiol 24: 1536–1543

    Article  Google Scholar 

  16. Enriques-Sarano M, Schaaf HV, Orszulak TA et al. (1995) Valve repair improves the outcome of surgery for mitral regurgitation: a multi-variate analysis. Circulation 91: 1022–1028

    Article  Google Scholar 

  17. Galan A, Zoghbi WA, Quinones MA (1991) Determination of severity of valvular aortic stenosis by doppler echocardiography and relation of findings to clinical outcome and agreement with hemodynamic measurements determined at cardiac catheterization. Am J Cardiol 67: 1007–1012

    Article  CAS  PubMed  Google Scholar 

  18. Garbarez E, Iung B, Cormier B et al. (1999) Echocardiographic criteria in selection of patients for percutaneous mitral commissurotomy. Echocardiography 16: 711–721

    Article  Google Scholar 

  19. Hochreiter C, Niles N, Devereux RB (1986) Mitral regurgitation: relationship of noninvasive descritors of right and left ventricular performance to clinical and hemodynymic findings and to prognosis in medically and surgically treated patients. Circulation 73: 900–912

    Article  CAS  PubMed  Google Scholar 

  20. Horstkotte D, Loogen F (1988) The natural history of aortic valve stenosis. Eur Heart J (Suppl E) 9: 57–64

    Article  PubMed  Google Scholar 

  21. Horstkotte D, Niehues R, Strauer BE (1991) Pathomorphological aspects, aetiology and natural history of acquired mitral valve stenosis. Eur Heart J (Suppl) 12: 55–60

    Article  PubMed  Google Scholar 

  22. Ishii K, Hirota Y, Suwa M et al. (1996) Natural history and left ventricular response in chronic aortic regurgitation. Am J Cardiol 78: 357

    Article  CAS  PubMed  Google Scholar 

  23. Iung B, Drissi MF, Michel PL et al. (1993) Prognosis of valve replacement for aortic stenosis with or without coexisting coronary heart disease: a comparative study. J Heart Valve Dis 2: 430–439

    CAS  PubMed  Google Scholar 

  24. Julius BK, Spillmann M, Vassalli G et al. (1997) Angina pectoris in patients with aortic stenosis and normal coronary arteries: mechanisms and pathophysiological concepts. Circulation 95: 892–898

    Article  CAS  PubMed  Google Scholar 

  25. Kaufmann P, Vassalli G, Lupi Wagner S et al. (1996) Coronary artery dimensions in primary and secondary left ventricular hypertrophy. J Am Coll Cardiol 28: 745–750

    CAS  PubMed  Google Scholar 

  26. Kim S, Kuroda T, Nishinaga M et al. (1996) Relationship between severity of mitral regurgitation and prognosis of mitral valve prolapse: echocardiographic follow-up study. Am Heart J 132: 348–355

    Article  CAS  PubMed  Google Scholar 

  27. Lee MM, Park SW, Kim CH et al. (1993) Relation of pulmonary venous flow to mean atrial pressure in mitral stenosis with sinus rhythm. Am Heart J 126: 1401–1407

    Article  CAS  PubMed  Google Scholar 

  28. Leung DY, Griffin BP, Stewart WJ et al. (1996) Left ventricular function after valve repair for chronic mitral regurgitation: predictive value of preoperative assessment of contractile reserve by exercise echocardiography. J Am Coll Cardiol 28: 1198–1205

    Article  CAS  PubMed  Google Scholar 

  29. Ling LH, Enriques-Sarano M, Seward JB et al. (1996) Clinical outcome of mitral regurgitation due to flail leaflet. N Engl J Med 335: 1417–1423

    Article  CAS  PubMed  Google Scholar 

  30. Naqri TZ, Siegel RJ (1999) Aortic stenosis: the role of transesophageal echocardiography. Echocardiography 16: 677–688

    Article  Google Scholar 

  31. Otto CM (1999) In: Otto CM (eds) Valvular heart disease. Saunders, Philadelphia

  32. Otto CM, Burwash IG, Legget ME et al. (1997) A prospective study of asymptomatic valvular aortic stenosis: clinical, echocardiographic and exercise predictors of outcome. Circulation 95: 2262–2270

    Article  CAS  PubMed  Google Scholar 

  33. Padial L, Freitas N, Sagie A et al. (1996) Echocardiography can predict which patients will develop severe mitral regurgitation after percutaneous mitral valvulotomy. J Am Coll Cardiol 27: 1225–1231

    Article  CAS  PubMed  Google Scholar 

  34. Pape LA, Price JM, Alpest JS et al. (1991) Relation of left atrial size to pulmonary capillary wedge pressure in severe mitral regurgitation. Cardiology 78: 297–303

    Article  CAS  PubMed  Google Scholar 

  35. Rahimtoola SA (1997) Chronic mitral regurgitation. In: Alpert JS, Dalen JE (eds) Valvular heart disease, St Louis

    Google Scholar 

  36. Reed D, Abbott RD, Smucker ML et al. (1991) Prediction of outcome after mitral valve replacement in patients with symptomatic chronic mitral regurgitation: the importance of left atrial size. Circulation 84: 23–34

    Article  CAS  PubMed  Google Scholar 

  37. Reid CL (1997) Echocardiography in the patient undergoing catheter balloon mitral commissurotomy. In Otto CM (ed) The practice of clinical echocardiography. Saunders, Philadelphia, pp 373–388

    Google Scholar 

  38. Sagie A, Freitas N, Chen MH et al. (1997) Echocardiographic assessment of mitral stenosis and in associated valvular lesions in 205 patients and lack of association with mitral valve prolapse. J Am Soc Echocardiog 10: 141–148

    Article  CAS  Google Scholar 

  39. Sciemienczuk D, Greenberg B, Morris C et al. (1989) Chronic aortic insufficiency: factors associated with progression to aortic valve replacement. Ann Intern Med 110: 587

    Article  Google Scholar 

  40. Scognamiglio R, Fasoli G, Dalla Volta S (1986) Progression of myocardial dysfunction in asymptomatic patients with severe aortic insufficiency. Clin Cardiol 9: 151

    Article  CAS  PubMed  Google Scholar 

  41. Scognamiglio R, Rahimtoola S, Fasoli G et al. (1994) Nifedipine in asymptomatic patients with severe aortic regurgitation and normal left ventricular function. N Engl J Med 331: 689

    Article  CAS  PubMed  Google Scholar 

  42. Selzer A (1987) Changing aspects of the natural history of valvular aortic stenosis. N Engl J Med 317: 91–98

    Article  CAS  PubMed  Google Scholar 

  43. Tornos MP, Olona M, Permanyer-Miralda G et al. (1995) Clinical outcome of severe asymptomatic chronic aortic regurgitation: a long-term prospective follow-up study. Am Heart J 130: 333

    Article  CAS  PubMed  Google Scholar 

  44. Wilkins GT, Weyman AE, Abascal VM et al. (1988) Percutaneous balloon dilatation of the mitral valve: an analysis of echocardiographic variables related to outcome and the mechanism of dilatation. Br Heart J 60: 299–308

    Article  CAS  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sebastian Reith.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reith, S., Körtke, H., Volk, O. et al. Aktuelle Diagnostik und Therapie von Herzklappenerkrankungen. Z Kardiol 90 (Suppl 6), 13–21 (2001). https://doi.org/10.1007/s003920170003

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s003920170003

Key words

Schlüsselwörter

Navigation