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New technologies for intensive prevention programs after myocardial infarction: rationale and design of the NET-IPP trial

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Abstract

Introduction

Current health care data reveal suboptimal prevention in patients with coronary artery disease and an unmet need to develop effective preventive strategies. The New Technologies for Intensive Prevention Programs (NET-IPP) Trial will investigate if a long-term web-based prevention program after myocardial infarction (MI) will reduce clinical events and risk factors. In a genetic sub study the impact of disclosure of genetic risk using polygenic risk scores (PRS) will be assessed.

Study design

Patients hospitalized for MI will be prospectively enrolled and assigned to either a 12-months web-based intensive prevention program or standard care. The web-based program will include telemetric transmission of risk factor data, e-learning and electronic contacts between a prevention assistant and the patients. The combined primary study endpoint will comprise severe adverse cardiovascular events after 2 years. Secondary endpoints will be risk factor control, adherence to medication and quality of life. In a genetic sub study genetic risk will be assessed in all patients of the web-based intensive prevention program group by PRS and patients will be randomly assigned to genetic risk disclosure vs. no disclosure. The study question will be if disclosure of genetic risk has an impact on patient motivation and cardiovascular risk factor control.

Conclusions

The randomized multicenter NET-IPP study will evaluate for the first time the effects of a long-term web-based prevention program after MI on clinical events and risk factor control. In a genetic sub study the impact of disclosure of genetic risk using PRS will be investigated.

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Funding

The study is funded by the Stiftung Bremer Herzen.

Author information

Authors and Affiliations

  1. Bremen Institute for Heart and Circulation Research at the Klinikum Links der Weser, Senator-Wessling-Str. 1, 28277, Bremen, Germany

    Harm Wienbergen, Andreas Fach, Rico Osteresch, Johannes Schmucker & Rainer Hambrecht

  2. Medical Clinic II, Lübeck University Heart Center, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Harm Wienbergen, Roza Meyer-Saraei, Ingo Eitel & Harald Langer

  3. Institute for Cardiogenetics, Lübeck University Heart Center, Lübeck, Germany

    Jeanette Erdmann & Matthias Munz

  4. Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany

    Alexander Katalinic & Nora Eisemann

  5. Institute for Genomic Statistics and Bioinformatics, University Hospital of Bonn, Bonn, Germany

    Peter Krawitz, Carlo Maj & Oleg Borisov

  6. Institute of Human Genetics, University Hospital of Bonn, Bonn, Germany

    Markus Noethen

  7. Heart Center, University Hospital Carl Gustav Carus Dresden, Dresden, Germany

    Axel Linke

Authors
  1. Harm Wienbergen
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  2. Andreas Fach
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  3. Jeanette Erdmann
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  7. Carlo Maj
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  11. Roza Meyer-Saraei
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  12. Rico Osteresch
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  13. Johannes Schmucker
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  14. Axel Linke
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  15. Ingo Eitel
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  16. Rainer Hambrecht
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  17. Harald Langer
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Corresponding author

Correspondence to Harm Wienbergen.

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Wienbergen, H., Fach, A., Erdmann, J. et al. New technologies for intensive prevention programs after myocardial infarction: rationale and design of the NET-IPP trial. Clin Res Cardiol 110, 153–161 (2021). https://doi.org/10.1007/s00392-020-01695-w

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  • DOI: https://doi.org/10.1007/s00392-020-01695-w

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