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Cardioverter–defibrillator does not improve short-term survival among patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction

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Abstract

Introduction

The DANISH trial raised doubts about the effectiveness of primary prevention of sudden cardiac death by ICD implantation among patients with non-ischemic heart failure. We sought to analyse data from the EVITA-HF registry to give an answer from real-world registry data to the DANISH trial.

Methods

1804 patients were identified from the EVITA-HF registry with chronic heart failure (CHF) due to ischemic or dilated heart disease and reduced left ventricular ejection fraction of ≤ 35%. The patients were divided into two groups: Patients with newly implanted cardioverter–defibrillator (ICD group; mean age 66 ± 12 years, 77% male) and without ICD (no-ICD group; mean age 66 ± 14 years, 77% male). The subgroups were compared with regard to mortality and predictive parameters affecting survival.

Results

Cardiovascular risk factors were similar among patients in the non-ICD group (n = 1473) compared to ICD group (n = 331). After 1-year follow-up patients with ischemic heart disease showed a significant improved survival in the ICD group compared to non-ICD group [92.1% vs. 80.6%, HR 0.37 (0.22–0.62)]. Patients with non-ischemic cardiomyopathy did not show a difference with regard to survival between the ICD and the non-ICD group [93.7% vs. 93.1%, HR 0.92 (0.43–1.97)]. The data were stable in a Cox-regression model.

Conclusion

In a real-world setting, no benefit was evident for patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction by adding ICD therapy in a short-term follow-up of 12 months in contrast to patients with ischemic cardiomyopathy.

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Authors and Affiliations

  1. Peter Osypka Herzzentrum München, Internistisches Klinikum München Süd, Munich, Germany

    Clemens Jilek & Thorsten Lewalter

  2. Klinik für Kardiologie, Klinikum Nürnberg, Nuremberg, Germany

    Matthias Pauschinger

  3. I. Medizinische Klinik, Klinikum Augsburg, Augsburg, Germany

    Wolfgang von Scheidt

  4. Klinik für Innere Medizin III: Kardiologie, Angiologie und Pneumologie, Uniklinikum, Heidelberg, Germany

    Lutz Frankenstein

  5. Klinik für Kardiologie, Universitätsspital Basel, Basel, Switzerland

    Otmar Pfister

  6. Klinik für Kardiologie und Angiologie, Klinikum links der Weser, Bremen, Germany

    Rainer Hambrecht

  7. Klinik für Kardiologie und Angiologie, Elisabeth-Krankenhaus Essen, Essen, Germany

    Oliver Bruder

  8. Klinik für Kardiologie, Angiologie und Pneumologie, Regiomed Kliniken Coburg, Coburg, Germany

    Johannes Brachmann

  9. Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Leipzig, Germany

    Andreas Hartmann

  10. Klinik für Innere Medizin und Kardiologie, Uniklinikum Dresden, Dresden, Germany

    Ruth Strasser

  11. Stiftung Institut für Herzinfarktforschung Ludwigshafen, Ludwigshafen, Germany

    Matthias Hochadel & Jochen Senges

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  1. Clemens Jilek
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  2. Thorsten Lewalter
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  8. Oliver Bruder
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Correspondence to Clemens Jilek.

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Jilek, C., Lewalter, T., Pauschinger, M. et al. Cardioverter–defibrillator does not improve short-term survival among patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction. Clin Res Cardiol 109, 115–123 (2020). https://doi.org/10.1007/s00392-019-01503-0

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  • DOI: https://doi.org/10.1007/s00392-019-01503-0

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