Severe eosinophilic myocarditis associated with modafinil in a patient with normal peripheral eosinophil count
- 79 Downloads
Eosinophilic myocarditis (EM) is a rare form of myocardial inflammation characterized by myocardial eosinophilic infiltration . It can lead to a broad spectrum of clinical symptoms, ranging from asymptomatic cases to dramatic and life-threatening progression with rapid myocardial damage and acute heart failure [1, 2, 3, 4]. The etiology is heterogeneous and hypersensitivity or allergic reactions as well as hematological diseases or neoplastic disorders can lead to EM . Eosinophilia in peripheral blood is present in the majority of patients and often suggestive for the diagnosis [1, 5]. EM in the absence of hypereosinophilia, however, is a diagnostic challenge and can lead to a potentially fatal delay in suitable treatment . We present the second description of modafinil-associated acute necrotizing myocarditis after a fatal case, which was published in 2006 . In our case, timely diagnosis by histology and administration of corticosteroid therapy enabled full recovery.
Compliance with ethical standards
Conflict of interest
All authors agreed to submit this case report and declared no conflict of interests.
- 13.Shoaib A, Farag M, Nolan J, Rigby A, Patwala A, Rashid M, Kwok CS, Perveen R, Clark AL, Komajda M, Cleland JGF (2018) Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the first euro heart failure survey. Clin Res Cardiol. https://doi.org/10.1007/s00392-018-1380-6 Google Scholar