Reply to the letter “Cardiac autonomic evaluation in breast cancer patients: role of cytokines and heart rate recovery”
- 120 Downloads
We received a letter about our recently published article. Okutucu et al. have suggested certain evaluations for future investigations. The suggestions were about assessments of cardiac autonomic modulation, cytokines and heart rate recovery (HRR) in breast cancer patients. We agree with the authors and are thankful for the suggestions. Our responses to these suggestions are given in the following.
We agree with the authors and consider that investigating the relationship between breast cancer staging, cardiac autonomic modulation and inflammation is promising. In our article, we also discussed our result (i.e., lower vagal modulation in advanced breast cancer patients compared to early-stages) and we proposed that this could be due to the neuroimmunomodulatory role of the vagus nerve in cancer . Cancer tumors progress under the influence of inflammation . Animal model studies have shown interesting relationships between vagal modulation, inflammation and tumor...
- 3.Partecke LI, Käding A, Trung DN, Diedrich S, Sendler M, Weiss F, Kühn JP, Mayerle J, Beyer K, von Bernstorff W, Heidecke CD, Keßler W (2017) Subdiaphragmatic vagotomy promotes tumor growth and reduces survival via TNFa in a murine pancreatic cancer model. Oncotarget 8:22501–22502. https://doi.org/10.18632/oncotarget.15019 CrossRefPubMedPubMedCentralGoogle Scholar
- 7.Pierce BL, Ballard-Barbash R, Bernstein L, Baumgartner RN, Neuhouser ML, Wener MH, Baumgartner KB, Gilliland FD, Sorensen BE, McTiernan A, Ulrich CM (2009) Elevated biomarkers of inflammation are associated with reduced survival among breast cancer patients. J Clin Oncol 27:3437–3444. https://doi.org/10.1200/JCO.2008.18.9068 CrossRefPubMedPubMedCentralGoogle Scholar