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Clinical Research in Cardiology

, Volume 107, Issue 6, pp 524–526 | Cite as

The clinical relevance of drug–drug interaction between co-trimoxazole and sacubitril/valsartan treatment in a heart failure patient: a case report and overview of mechanisms and management in clinical practice

  • Eleni S. Nakou
  • Maria E. Marketou
  • Panos E. Vardas
  • Fragiskos I. Parthenakis
Letter to the Editors

Sirs:

Given the high prevalence of comorbidities needed to be treated in heart failure (HF) population, sacubitril/valsartan, which is the new promising therapy in HF, has been assessed for potential pharmacokinetic or pharmacodynamic drug–drug interactions that could result in adverse events. These potential complications pose a therapeutic dilemma, since they may deter the majority of patients from enjoying the cardiovascular benefits of sacubitril/valsartan (LCZ696) treatment [1] or even increase the burden of morbidity. Despite the existing evidence, real-world data on its safety in combination with concurrent medications are eagerly expected. We present an interesting case of a patient presenting with hyperkalemia caused by the co-administration of LCZ696 and co-trimoxazole (sulfamethoxazole/trimethoprim), highlighting the underlying pathophysiological mechanisms and the clinical approach to patients at risk of hyperkalemia caused by the drug interactions with the novel therapy,...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of CardiologyHeraklion University HospitalHeraklion-CreteGreece

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