Clinical Research in Cardiology

, Volume 107, Issue 4, pp 362–367 | Cite as

Systemic inflammation and functional capacity in elderly heart failure patients

  • Sara Radenovic
  • Goran Loncar
  • Andreas Busjahn
  • Svetlana Apostolovic
  • Marija Zdravkovic
  • Valentina Karlicic
  • Jovan Veskovic
  • Elvis Tahirovic
  • Javed Butler
  • Hans-Dirk Düngen
Original Paper



Elevated C-reactive protein (CRP) is associated with adverse outcomes in heart failure (HF) patients. Beta-blocker therapy may lower CRP levels.

Methods and results

To assess if the changes of high-sensitivity (hs) CRP levels in HF patients over 12-week titration with beta-blockers correlate with functional capacity, plasma hs-CRP levels were measured in 488 HF patients [72.1 ± 5.31 years, LVEF 40% (33/50)]. Hs-CRP, NT-proBNP and 6-min-walk-test (6MWT) were assessed at baseline and at week 12. Patients were divided based on hs-CRP changes (cut-off > 0.3 mg/dl) into low–low (N = 225), high–high (N = 132), low–high (N = 54), high–low (N = 77) groups. At baseline, median hs-CRP concentration was 0.25 (0.12/0.53) mg/dl, NT-proBNP 551 (235/1455) pg/ml and average 6MWT distance 334 ± 105 m. NT-proBNP changes were significantly different between the four hs-CRP groups (P = 0.011). NT-proBNP increased in the low–high group by 30 (− 14/88) pg/ml and decreased in the high–low group by − 8 (− 42/32) pg/ml. 6MWT changes significantly differed between groups [P = 0.002; decrease in the low–high group (− 18 ± 90 m) and improvement in the low–low group (24 ± 62 m)].


After beta-blocker treatment, hs-CRP levels are associated with functional capacity in HF patients. Whether this represents a potential target for intervention needs further study.


Inflammation Hs-CRP NT-proBNP 6-min-walk-test 


Compliance with ethical standards

Conflict of interest

J. Butler: Consultant to Amgen, Astra Zeneca, Bayer, Boehringer Ingelheim, Janssen, Novartis, Relypsa, Trevena, ZS Pharma, Stealth Peptide, Medtronic, Merck, CVRx, Luitpold, and Vifor.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Sara Radenovic
    • 1
  • Goran Loncar
    • 2
    • 3
  • Andreas Busjahn
    • 4
  • Svetlana Apostolovic
    • 5
  • Marija Zdravkovic
    • 6
  • Valentina Karlicic
    • 7
  • Jovan Veskovic
    • 1
  • Elvis Tahirovic
    • 1
  • Javed Butler
    • 8
  • Hans-Dirk Düngen
    • 1
  1. 1.Department of CardiologyCharité UniversitätsmedizinBerlinGermany
  2. 2.Cardiology DepartmentZvezdara University Medical CenterBelgradeSerbia
  3. 3.Faculty of MedicineUniversity of BelgradeBelgradeSerbia
  4. 4.HealthTwiSt GmbHBerlinGermany
  5. 5.Clinic for Cardiovascular DiseasesClinical Center NisNisSerbia
  6. 6.Department of Cardiology, Faculty of Medicine, University Hospital Medical Center Bezanijska KosaUniversity of BelgradeBelgradeSerbia
  7. 7.Health Center CacakCacakSerbia
  8. 8.Cardiology DivisionStony Brook UniversityStony BrookUSA

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