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Table 6 Interaction analysis of sex, treatment, and HF interaction (unadjusted) (n = 1091)

From: Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study

Outcome p value for interactiona sex by treatment p value for interactiona sex by HFpEF p value for interactiona HFpEF by treatment p value for interactiona sex by treatment by HF
Dyspnea VAS AUC to day 5 0.4714 0.4987 0.2436 0.0945
Dyspnea Likert scale moderately/marked better at 6, 12, and 24 h 0.6301 0.1481 0.5462 0.2927
Days alive and out of hospital through day 60 0.0790 0.0737 0.0488 0.0737
CV death or HF/RF rehospitalization through day 60 0.7925 0.5682 0.9335 0.9726
CV death through day 60 0.2961 0.1565 0.2685 0.1468
HF rehospitalization through day 60 0.5582 0.9552 0.5330 0.4230
RF rehospitalization through day 60 0.9947 1.0000 0.9970 0.9999
All-cause death through day 180 0.9661 0.3898 0.7160 0.7908
Time to moderately or markedly better dyspnea through day 5 (days) 0.7899 0.5204 0.2896 0.1543
SCr increase of ≥0.3 mg/dL above baseline through day 5 0.0602 0.4721 0.8447 0.7312
Worsening heart failure through day 5 0.4598 0.3090 0.0864 0.0319
  1. HFpEF vs. HFrEF
  2. Subjects with missing HF were omitted from the analysis
  3. aInteraction p value comes from multiple linear regression models for continuous outcomes, logistic regression models for categorical outcomes, Cox proportional hazards models for time-to-event outcomes