Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study

Table 5 Interaction analysis of sex and treatment interaction (unadjusted) (n = 1161)

Outcome	p value for interaction^a sex by treatment
All-cause death through day 180	0.7229
CV death through day 60	0.7151
Days alive and out of hospital through day 60	0.2473
CV death or HF/RF rehospitalization through day 60	0.7247
RF rehospitalization through day 60	0.9933
HF rehospitalization through day 60	0.8778
Worsening heart failure through day 5	0.6764
SCr increase of ≥0.3 mg/dL above baseline through day 5	0.0585
Dyspnea VAS AUC to day 5	0.9228
Time to moderately or markedly better dyspnea through day 5 (days)	0.2050
Dyspnea Likert scale moderately/marked better at 6, 12, and 24 h	0.3869

^aInteraction p value comes from multiple linear regression models for continuous outcomes, logistic regression models for categorical outcomes, Cox proportional hazards models for time-to-event outcomes