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Table 3 Inotrope/vasoactive medication, diuretic doses, treatment response and post-discharge outcome by sex

From: Sex differences in early dyspnea relief between men and women hospitalized for acute heart failure: insights from the RELAX-AHF study

  Total cohorta (n = 1161) Mena (n = 725) Womena (n = 436) p valueb
Inotrope/vasoactive medication
 All IV inotrope/vasoactive agents through day 5 161 (13.9) 93 (12.8) 68 (15.6) 0.1862 [C]
 Nitroglycerin 127 (10.9) 66 (9.1) 61 (14.0) 0.0098 [C]
Diuretic doses and treatment response
 Total IV loop diuretic dose through day 5 (mg) 187.21 (316.02) 215.36 (364.91) 140.76 (204.10) <0.0001 [S]
 Total oral loop diuretic dose through day 5 (mg) 187.70 (191.79) 199.12 (204.05) 168.86 (168.20) 0.0067 [S]
Treatment response
 Study day of moderately or markedly improved dyspnea through day 5 1.72 (2.00) 1.87 (2.07) 1.48 (1.85) 0.0005 [W]
 Study day of worsening HF through day 5 5.65 (1.19) 5.61 (1.25) 5.71 (1.08) 0.1395 [W]
 Worsening HF through day 14 157 (13.56%) 106 (14.67%) 51 (11.71%) 0.1522 [L]
Change in bodyweight from baseline (kg)
 Day 1 −1.48 (1.98) −1.56 (2.11) −1.33 (1.73) 0.0433 [S]
 Day 2 −2.03 (2.46) −2.13 (2.65) −1.87 (2.09) 0.0752 [S]
 Day 5 −2.86 (3.34) −2.93 (3.50) −2.76 (3.05) 0.4210 [S]
 Day 14 −3.31 (4.26) −3.49 (4.60) −3.02 (3.64) 0.0642 [S]
Relative change in bodyweight from baseline (%)
 Day 1 −1.82 (2.38) −1.83 (2.44) −1.81 (2.28) 0.8637 [1]
 Day 2 −2.48 (2.90) −2.45 (2.97) −2.53 (2.80) 0.6483 [1]
 Day 5 −3.46 (3.91) −3.30 (3.84) −3.72 (4.01) 0.0797 [1]
 Day 14 −3.87 (4.75) −3.82 (4.89) −3.95 (4.53) 0.6780 [1]
Outcome
 Uncontrolled blood pressurec 271 (23.3%) 157 (21.7%) 114 (26.1%) 0.0798 [C]
 Length of ICU/CCU stay (days) 3.71 (7.04) 3.51 (6.63) 4.05 (7.67) 0.0248 [W]
 Length of initial hospital stay (days) 10.06 (9.34) 9.87 (9.17) 10.37 (9.62) 0.0258 [W]
 Days alive and out of hospital before day 30 20.61 (6.64) 20.68 (6.80) 20.47 (6.38) 0.1001 [W]
 Death or worsening HF or readmission to hospital for HF through day 30 200 (17.30%) 129 (17.87%) 71 (16.34%) 0.4556 [L]
 CV death or readmission to hospital for HF or renal failure through day 30 83 (7.20%) 50 (6.95%) 33 (7.62%) 0.6769 [L]
 CV death or readmission to hospital for HF or renal failure through day 30 after discharge 92 (8.17%) 55 (7.82%) 37 (8.76%) 0.5790 [L]
 All-cause death through day 30 31 (2.68%) 16 (2.22%) 15 (3.46%) 0.2100 [L]
 All-cause death or readmission to hospital for HF or renal failure through day 60 154 (13.36%) 97 (13.48%) 57 (13.17%) 0.9028 [L]
 CV death through day 180 88 (7.68%) 57 (7.98%) 31 (7.20%) 0.6484 [L]
 All-cause death through day 180 107 (9.31%) 68 (9.46%) 39 (9.06%) 0.8059 [L]
  1. aMean (SD) for continuous variables; n (%) for categorical variables (% based on total number of patients with a non-missing value of the characteristic); and number of events (K-M%) for time-to-event variables
  2. bBased on Satterthwaite method [S] (if equal variance assumption violated) for continuous variables, Wilcoxon rank sum test [W] for count variables, Chi squared test [C] for categorical variables, and logrank test [L] for time-to-event variables
  3. cUncontrolled blood pressure is defined as systolic >150 mmHg or diastolic >90 mmHg at day 2 and through day 5, or at time of discharge (if discharge time ≤day 5), whichever occurs first