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Association of vitamin D status and blood pressure response after renal denervation

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Abstract

Background

Vitamin D deficiency is associated with hypertension; however, it is unclear whether vitamin D influences therapeutic blood pressure reduction. Renal sympathetic denervation (RDN) reduces blood pressure in resistant hypertension. We hypothesized that vitamin D might influence blood pressure response to RDN.

Methods

Vitamin D was measured in 101 patients with resistant hypertension undergoing RDN. The associations between vitamin D status and systolic blood pressure (SBP) reduction 6 months after RDN were analyzed.

Results

Mean office SBP at baseline was 171.5 ± 2 mmHg. After RDN, mean office SBP was reduced by 28.4 ± 2.3 mmHg (p = 0.007). 85 patients (84.2 %) had SBP reductions >10 mmHg (responders). Vitamin D concentrations were lower in non-responders as compared to responders (9.9 ± 4.5 vs. 13.7 ± 7.4 ng/ml, p = 0.008). Non-responders (n = 16, 15.8 %), more often had a vitamin D concentration below the median as compared to responders (81 vs. 46 %, p = 0.013). The percentage of patients with normal vitamin D concentrations increased with increasing tertiles of SBP reduction (p for trend = 0.020). In patients with vitamin D concentrations below the median, SBP reduction was lower as compared to patients with a vitamin D concentration above the median (23.5 ± 3.2 vs. 33.7 ± 3.2 mmHg, p = 0.026). Baseline vitamin D concentrations correlated with SBP reduction (r = 0.202, p = 0.043).

Conclusions

In patients with resistant hypertension, low vitamin D concentrations were associated with a decreased SBP response and a higher rate of non-response.

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Acknowledgments

FM, CU and MB are supported by the Ministry of Science and Economy of the Saarland. FM is supported by the Deutsche Hochdruckliga. FM and MB are supported by the Deutsche Forschungsgemeinschaft (KFO 196). MS is supported by an NHMRC Senior Research Fellowship.

Conflict of interest

All authors received scientific support from Medtronic Ardian Inc. FM, BC, CU, MS, ME, UL, and MB received speaker honorarium from Medtronic.

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Authors and Affiliations

  1. Klinik für Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Straße, 66421, Homburg/Saar, Germany

    Janine Pöss, Felix Mahfoud, Christian Ukena, Bodo Cremers, Ulrich Laufs & Michael Böhm

  2. Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, Australia

    Murray David Esler, Markus Schlaich & Dagmara Hering

  3. Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland

    Dagmara Hering

Authors
  1. Janine Pöss
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  2. Felix Mahfoud
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  3. Christian Ukena
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Corresponding author

Correspondence to Janine Pöss.

Additional information

J. Pöss and F. Mahfoud contributed equally to this study.

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Pöss, J., Mahfoud, F., Ukena, C. et al. Association of vitamin D status and blood pressure response after renal denervation. Clin Res Cardiol 103, 41–47 (2014). https://doi.org/10.1007/s00392-013-0621-y

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  • DOI: https://doi.org/10.1007/s00392-013-0621-y

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