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Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease

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Abstract

Background

Few studies have prospectively addressed the effects of exercise in the inflammatory activity of patients with coronary artery disease (CAD). We sought to evaluate the consequences of an acute bout of exercise on inflammatory markers and BNP in untrained CAD patients before and after randomization to a training program.

Methods

34 CAD patients underwent a 50-min acute exercise session on a cycle-ergometer at 65% peak oxygen uptake before and after blood sampling. They were then randomized to a 4-month chronic exercise program (15 patients) or general lifestyle recommendations (19 patients), undergoing a new acute session of exercise after that.

Results

In the overall population, acute exercise caused a significant increase in C-reactive protein [CRP; 1.79 (4.49) vs. 1.94 (4.89) mg/L, P < 0.001], monokine induced by interferon-γ [Mig; 351 (324) vs. 373 (330) pg/mL, P = 0.027] and vascular adhesion molecule-1 [VCAM-1; 226 (82) vs. 252 (110) pg/mL, P = 0.02]. After 4-months, in exercise-trained patients, there was a significant decrease in the inflammatory response provoked by the acute exercise compared to patients in the control group reflected by a significant decrease in the differences between rest and post-exercise levels of CRP [−0.29 (0.84) mg/L vs. −0.11 (0.21) mg/L, P = 0.05]. Resting BNP was also significantly lower in exercise-trained patients when compared to untrained controls [15.6 (16.2) vs. 9.7 (11.4) pg/mL, P = 0.04 and 19.2 (27.8) vs. 23.2 (27.5) pg/mL, P = 0.76; respectively].

Conclusions

Chronic exercise training might partially reverse the inflammatory response caused by acute exercise in CAD patients. These results suggest that regular exercise is an important nonpharmacological strategy to the improvement in inflammation in CAD patients.

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Acknowledgments

This study was supported by grants from Fundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP), Brazil.

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Authors and Affiliations

  1. University of Campinas (Unicamp), R. Antonio Lapa 1032, Campinas, SP, 13025-242, Brazil

    Juliano Lara Fernandes, Augusto Zamperini, Fabio H Teo, Romulo T Oliveira & Maria Heloisa Blotta

  2. Heart Institute, University of São Paulo Medical School, São Paulo, Brazil

    Carlos Vicente Serrano Jr, Flavia Toledo, Maria Fernanda Hunziker, Maria Urbana Rondon & Carlos Eduardo Negrão

Authors
  1. Juliano Lara Fernandes
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  2. Carlos Vicente Serrano Jr
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  3. Flavia Toledo
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Correspondence to Juliano Lara Fernandes.

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Lara Fernandes, J., Serrano, C.V., Toledo, F. et al. Acute and chronic effects of exercise on inflammatory markers and B-type natriuretic peptide in patients with coronary artery disease. Clin Res Cardiol 100, 77–84 (2011). https://doi.org/10.1007/s00392-010-0215-x

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  • DOI: https://doi.org/10.1007/s00392-010-0215-x

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