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Percutaneous septal ablation after unsuccessful surgical myectomy for patients with hypertrophic obstructive cardiomyopathy

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Abstract

Objective

To evaluate the long-term outcome of percutaneous septal ablation (PTSMA) after a previous myectomy.

Background

Myectomy usually results in symptomatic improvement and reduction of dynamic obstruction in hypertrophic obstructive cardiomyopathy patients (HOCM-pts.). However, a few pts. remain with severe symptoms and obstruction, and need additional interventions.

Methods

We reviewed our database of 450 pts. who underwent PTSMA in our institution, and identified 11 (7 women, 4 men, mean age: 50 ± 14 years) with residual or recurrent NYHA class symptoms ≥III and significant left ventricular outflow obstruction (LVOTO) despite a previous myectomy 4 ± 5 years ago. In-hospital and follow-up data covering 6 ± 4 years, focusing on mortality and morbidity, symptoms, exercise capacity, and echocardiographic measures were collected.

Results

PTSMA was performed by injection of 3.6 ± 2.9 ml of alcohol. There was no peri-procedural or late death in this cohort. CK peaked at 614 ± 434 U/l. In addition to two pts. who already had a pacemaker implanted, two more (18%) who both had pre-existing left bundle branch block were pacemaker-dependent after PTSMA. During follow-up, 9 pts. (81%) reported significant and stable improvement. Two pts. (18%) developed progressive class III symptoms until their last follow-up, one of these together with persistent AF and a non-fatal stroke, the other received an ICD for primary prophylaxis and entered our pre-transplant program. Echo-Doppler showed sustained LVOTO elimination without global LV dilatation in all cases.

Conclusions

PTSMA is an effective non-surgical option for treating symptoms and residual or recurrent LVOTO after a previous surgical myectomy. The high rate of conduction disturbances in this post-surgical cohort translated into a higher rate of pacemaker dependency after PTSMA.

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Authors and Affiliations

  1. Department of Cardiology, Heart and Diabetes Center North-Rhine Westphalia, Ruhr University Bochum, Georgstr. 11, 32545, Bad Oeynhausen, Germany

    Lothar Faber MD, FESC, FACC, Dirk Welge MD, Detlef Hering MD, Olaf Oldenburg MD & Dieter Horstkotte MD

  2. Leopoldina Hospital, Schweinfurt, Germany

    Hubert Seggewiss MD

  3. Marienhospital Herne, Herne, Germany

    Thomas Butz MD

Authors
  1. Lothar Faber MD, FESC, FACC
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  2. Dirk Welge MD
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  3. Detlef Hering MD
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  4. Thomas Butz MD
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  5. Olaf Oldenburg MD
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  6. Hubert Seggewiss MD
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  7. Dieter Horstkotte MD
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Corresponding author

Correspondence to Lothar Faber MD, FESC, FACC.

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Faber, L., Welge, D., Hering, D. et al. Percutaneous septal ablation after unsuccessful surgical myectomy for patients with hypertrophic obstructive cardiomyopathy. Clin Res Cardiol 97, 899–904 (2008). https://doi.org/10.1007/s00392-008-0707-0

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  • DOI: https://doi.org/10.1007/s00392-008-0707-0

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