Skip to main content

Advertisement

SpringerLink
Log in

The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery

  • ORIGINAL PAPER
  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

Abstract

Background

Cognitive decline (CD) and delirium (PD) are commonly observed complications after bypass heart surgery. In this study we aimed to investigate whether certain genetic factors (alleles of the SOAT-1 gene) play a role in their appearance.

Patients and methods

We examined 137 patients receiving coronary bypass surgery with a neuropsychiatric test battery consisting of the Mini Mental State Examination (MMSE), the Brief Psychiatric Rating Scale (BPRS), the Wechsler's Memory Scale-Revised (WMS-R) on admission and one month after surgery, and the Delirium Rating Scale postoperatively, when indicated, and genotyped them in relation to the SOAT–1 genotypes (AA positive group with augmented protection of the nerve cells against stress and the AA negative group – AC and CC subgroups – with diminished protection against stress).

Results

We noted a significant decline in test results postoperatively and a high frequency of delirium (29.92% of the patients). None of these complications could be associated to the SOAT-1 genotypes.

Conclusions

Our study confirmed the expected cognitive decline and highly frequent delirium after bypass heart surgery and excluded the possible role of SOAT-1 genotype polymorphisms in their genesis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Elsasser A, Mollmann H, Nef HM, Hamm CW (2006) How to revascularize patients with diabetes mellitus: Bypass or stents and drugs? Clin Res Cardiol 95(4):195–203

    Article  PubMed  Google Scholar 

  2. Newman Mark F, Croughwell Nada D, Blumenthal James A et al (1995) Predictors of cognitive decline after cardiac operation. Ann Thorac Surg 59:1326–1330

    Article  PubMed  CAS  Google Scholar 

  3. Bucerius J, Gummert JF, Borger MA et al (2004) Predictors of delirium after cardiac surgery: effect of beating- heart (off pump) surgery. J Thoracic and Cardiovascular Surgery 127(1):7–9

    Article  Google Scholar 

  4. Jung W, Meyerfeldt U, Birkemeyer R (2006) Atrial arrhythmias after cardiac surgery in patients with diabetes mellitus. Clin Res Cardiol 95(Suppl 1):i88–i97

    Article  PubMed  Google Scholar 

  5. Rolfson DB, Mac Elhaney JE, Rockwood H et al (1999) Incidence and risk factors for delirium and other adverse outcomes in older adults after coronary artery bypass graft surgery. Can J Cardiol 15(7):771–776

    PubMed  CAS  Google Scholar 

  6. Tardiff BE, Newman MF , Saunders AM et al (1997) Preliminary report of a genetic basis for cognitive decline after cardiac operations. Ann Thorac Surg 64:715–720

    Article  PubMed  CAS  Google Scholar 

  7. Steed L, Kong R, Stygall J et al (2001) The role of apolipoprotein E in cognitive decline after cardiac operation. Ann of Thorac Surg 71:823–826

    Article  CAS  Google Scholar 

  8. Lelis RG, Krieger JE, Pereira AC, Schmidt AP, Carmona MJ, Olivaira SA, Auler JO Jr (2006) Apolipoprotein E4 genotype imcreases the risk of postoperative cognitive dysfunction in patients undergoing coronary artery bypass graft surgery. J Cardiovasc Surg (Torino) 47(4):451–456

    CAS  Google Scholar 

  9. Askar FZ, Cetin HY, Kumral E et al (2005) Apolipoprotein E epsilon 4 allele and neurobehavioral status after on- pump coronary artery bypass grafting. J Card Surg 20(5):501–505

    Article  PubMed  Google Scholar 

  10. Tagarakis GI, Tsolaki-Tagaraki F, Tsolaki M, Diegeler A, Papassotiropoulos A (2007) The role of apolipoprotein E in cognitive decline and delirium after bypass heart operations. Am J of Alzheimers Dis and Other Demen. June-July (in press)

  11. Wollmer MA, Streffer JR, Tsolaki M, Grimaldi LM, Lutjohann D, Thal D, von Bergmann H, Nitsch RM, Hock C, Papassotiropoulos A (2003) Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load and risk for Alzheimer’s disease. Mol Psychiatry 8(6):635–638

    Article  PubMed  CAS  Google Scholar 

  12. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT et al (2001) Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid betapeptide. Nat Cell Biol 3:905–912

    Article  PubMed  CAS  Google Scholar 

  13. Zhao FG, Wang YH, Yang JF, Ma OZ, Tang Z, Dong XM, Chan P (2005) Association between acyl- coenzyme A:cholesterol acyltransferase gene and risk for Alzheimer’s Disease in Chinese. Neuroscience Letters 388(1):17–20

    Article  PubMed  CAS  Google Scholar 

  14. Folstein MF, Folstein SE, Mac Hugh RR (1975) Mini Mental State: a practical method for grading the state of patients for the clinician. Journal of Psychiatric Research 12:189–198

    Article  PubMed  CAS  Google Scholar 

  15. Kessler J, Markowitsch HJ, Denzler P (1990) Der Mini Mental Status Test. Beltz, Weinheim

  16. Wechsler D (1987) Wechsler Memory Scale Revised, S CP San Antonio, Texas: The Psychological Corporation – Harcourt Brace Jovanovich

  17. Haerting C, Markowitsch HJ, Neufeld H, Calabrese P, Deisinger K, Kessler J (2000) Wechsler Gedächtnis Test – Revidierte Fassung (WMS-R), Huber, Bern

  18. Ventura MA, Green MF, Shaner A, Liberman RP (1993) Training and quality assurance with the brief psychiatric rating scale: “The drift buster”. International Journal of Methods in Psychiatric Research 3:221– 244

    Google Scholar 

  19. Trzepacz PT, Baker RW, Greenhouse J (1988) A symptom rating scale for delirium. Psychiatry Research 23(1):89–97

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Anaximandrou 24, 54250, Thessaloniki, Greece

    Georgios I. Tagarakis MD & Fani Tsolaki-Tagaraki MD

  2. Herz- und Gefäß-Klinik, Salzburger Leite 1, 97616, Bad Neustadt a.d Saale, Germany

    Georgios I. Tagarakis MD, Fani Tsolaki-Tagaraki MD & Anno Diegeler MD

  3. 3rd Department of Neurology, Papanikolaou Hospital Exochi, Thessaloniki, Greece

    Magdalini Tsolaki MD, PhD & Dimitrios Kazis MD, PhD

  4. Cardiology Department, University of Thessaly, Larrisa, Greece

    Effie Rouska MD

  5. Institute for Psychiatric Research, Lenggstrasse 32, 8230, Zurich, Switzerland

    Andreas Papassotiropoulos MD, PhD

Authors
  1. Georgios I. Tagarakis MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fani Tsolaki-Tagaraki MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Magdalini Tsolaki MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anno Diegeler MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Dimitrios Kazis MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Effie Rouska MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Andreas Papassotiropoulos MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Georgios I. Tagarakis MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tagarakis, G.I., Tsolaki-Tagaraki, F., Tsolaki, M. et al. The role of SOAT-1 polymorphisms in cognitive decline and delirium after bypass heart surgery. Clin Res Cardiol 96, 600–603 (2007). https://doi.org/10.1007/s00392-007-0539-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-007-0539-3

Key words

Search

Navigation