Skip to main content
Log in

Koronare Revaskularisation bei Diabetikern—

Stellenwert von arteriellen Grafts

Arterial grafts in coronary surgery for diabetic patients

  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

Summary

Surgical revascularization allows especially for the diabetic patient with coronary multi-vessel disease a superior long-termperspective compared to percutaneous coronary interventions. However, the specific advantages and also risks associated with the expanded use of arterial grafts as coronary conduits in diabetics are not clearly answered. A systemic analysis of the current literature underlines the following statements: The radial artery is, compared to the internal mammary artery, to a higher extent prone to atherosclerosis, especially in diabetic patients. Better long-term survival for patients with bilateral IMA-grafts has also been assessed for diabetic patients. The risk of thoracic wound infections is not obligatory increased for diabetics with double IMA-grafts. Revascularization with radial arteries can be performed with low perioperative risks. Long-term results or studies on radial artery bypass grafting especially in diabetics are not available. In our own experience (3,548 isolated coronary operations, 01/2001 until 05/2005), diabetic patients have no increased perioperative mortality, even when using more complex arterial grafting. Conclusively, diabetic patients should also significantly benefit from the use of the second mammary artery. Regarding conduit quality, a second IMA appears favorable over the radial artery.

Zusammenfassung

Gerade für den diabetischen Patienten mit koronarer Mehrgefäßerkrankung besitzen chirurgische Revaskularisationskonzepte entscheidende Überlebensvorteile im langfristigen Verlauf gegenüber perkutanen Revaskularisationsmaßnahmen. Welche Vorteile, aber auch Risiken der erweiterte Einsatz von arteriellen Grafts als Koronarbypass beim Diabetiker hat, ist bisher nicht klar formuliert. Eine systematische Analyse der aktuellen Literatur erbrachte folgende Ergebnisse: Die Radialarterie weist gegenüber Mammaria-Arterien in deutlich höherem Maße atherosklerotische Veränderungen mit besonderer Ausprägung beim Diabetiker auf. Der mit einer bilateralen Mammaria-Revaskularisation verbundene Überlebensvorteil gilt auch für Diabetiker. Das Risiko thorakaler Wundinfektionen ist dabei für den Diabetiker nicht zwangsläufig signifikant erhöht. Die Revaskularisation mit Radialarterien kann mit niedrigem perioperativem Risiko durchgeführt werden. Langzeitergebnisse oder Untersuchungen speziell zu Diabetikern liegen nicht vor. Im eigenem Krankengut (3 548 isolierte Bypassoperationen, 01/2001 bis 05/2005) haben Diabetiker insgesamt, aber auch bei komplexen Arterienkonzepten keine erhöhte perioperative Letalität. Letztlich dürften auch Diabetiker insbesondere von dem Einsatz der zweiten Mammaria-Arterie nachhaltig profitieren. Hinsichtlich der Konduiteigenschaften spricht vieles dafür, die zweite Mammaria-Arterie gegenüber der Radialarterie vorzuziehen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. BARI Investigators (1997) Influence of Diabetes on 5-Year Mortality and Morbidity in a Randomized Trial Comparing CABG and PTCA in Patients With Multivessel Disease. Circulation 96:1761–1769

    Google Scholar 

  2. Kaufer E, Factor SM, Frame R, Brodman RF (1997) Pathology of the Radial and Internal Thoracic Arteries Used as Coronary Artery Bypass Grafts. Ann Thorac Surg 63:1118–1122

    CAS  PubMed  Google Scholar 

  3. Kobayashi H, Kitamura S, Kawachi K, Morita R, Konishi Y, Tsutsumi M (1993) A pathohistological and biochemical study of arteriosclerosis in the internal thoracic artery, a vessel commonly used as a graft in coronary artery bypass surgery. Surg Today 23:697–703

    CAS  PubMed  Google Scholar 

  4. Lev-Ran O, Mohr R, Amir K, Matsa M, Nehser N, Locker C, Uretzky G (2003) Bilateral Internal Thoracic Artery Grafting in Insulin-Treated Diabetics: Should It be Avoided? Ann Thorac Surg 75:1872–1877

    PubMed  Google Scholar 

  5. Locker C, Mohr R, Lev-Ran O, Uretzky G, Frimerman A, Shaham Y, Shapira I (2004) Comparison of Bilateral Thoracic Artery Grafting With Percutaneous Coronary Interventions in Diabetic Patients. Ann Thorac Surg 78:471–476

    Article  PubMed  Google Scholar 

  6. Luciani N, Nasso G, Gaudino M, Abbate A, Glieca F, Alessandrini F, Girola F, Santarelli F, Possati G (2003) Coronary Artery Bypass Grafting in Type II Diabetic Patients: A Comparison Between Insulin-Dependent and Non-Insulin-Dependent Patients at Short- and Mid-Term Follow-Up. Ann Thorac Surg 76:1149–1154

    Article  PubMed  Google Scholar 

  7. Lytle BW, Blackstone EH, Sabik JF, Houghtaling P, Loop FD, Cosgrove DM (2004) The Effect of Bilateral Internal Thoracic Artery Grafting on Survival During 20 Postoperative Years. Ann Thorac Surg 78:2005–2014

    Article  PubMed  Google Scholar 

  8. O’Keefe JH, Backstone EH, Sergeant P, McCallister BD (1998) The optimal mode of coronary revascularization for diabetics. Eur Heart J:1696–1703

    Google Scholar 

  9. Royse AG, Royse CF, Tatoulis J et al (2000) Postoperative radial artery angiography for coronary artery bypass surgery. Eur J Cardiothorac Surg 17:294–304

    Article  CAS  PubMed  Google Scholar 

  10. Ruengsakulrach P, Sinclair R, Komeda M, Raman J, Gordon I, Buxton B (1999) Comparative Histopathology of Radial Artery Versus Internal Thoracic Artery and Risk Factors for Development of Intimal Hyperplasia and Atherosclerosis. Circulation 100 [Suppl II]:II-139–II-144

    CAS  Google Scholar 

  11. Schwartz L, Kip KE, Frye RL, Alderman EL, Schaff HV, Detre KM (2002) Coronary Bypass Graft Patency in Patients With Diabetes in the Bypass Angioplasty Revascularization Investigation (BARI). Circulation 106:2652–2658

    PubMed  Google Scholar 

  12. Stevens LM, Carrier M, Perrault LP, Hébert Y, Cartier R, Bouchard D, Fortier A, Pellerin M (2005) Influence of diabetes and bilateral internal thoracic artery grafts on long-term outcome for multivessel coronary artery bypass grafting. Eur J Cardiothorac Surg 27:281–288

    Article  CAS  PubMed  Google Scholar 

  13. Tatoulis J, Royse AG, Buxton BF, Fuller JA, Skillington PD, Goldblatt JC, Brown RP, Rowland MA (2002) The Radial Artery in Coronary Surgery: A 5-Year Experience—Clinical and Angiographic Results. Ann Thorac Surg 73:143–148

    Article  PubMed  Google Scholar 

  14. Weintraub WS, Stein B, Kosinski A, Douglas Jr JS, Ghazzai ZMB, Jones EL, Morris DC, Guyton RA, Craver JM, King III SB (1998) Outcome of Coronary Bypass Surgery Versus Coronary Angioplasty in Diabetic Patients With Multivessel Coronary Artery Disease. J Am Coll Cardiol 31:10–19

    CAS  PubMed  Google Scholar 

  15. Wendler O, Hennen B, Markwirth T, Nikoloudakis N, Graeter T, Schäfers H-J (2001) Complete Arterial Revascularization in the Diabetic Patient—Early Postoperative Results. Thorac Cardiov Surg 49:5–9

    CAS  Google Scholar 

  16. Wendler O, Landwehr P, Bandner-Risch D, Georg T, Schäfers H-J (2001) Vasoreactivity of arterial grafts in the patient with diabetes mellitus: investigations on internal thoracic artery and radial artery conduits. Eur J Cardiothorac Surg 20:305–311

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Cremer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cremer, J., Böning, A., Fraund, S. et al. Koronare Revaskularisation bei Diabetikern—. Clin Res Cardiol 95 (Suppl 1), i35–i39 (2006). https://doi.org/10.1007/s00392-006-1113-0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-006-1113-0

Key words

Schlüsselwörter

Navigation