Skip to main content

Advertisement

SpringerLink
Log in

Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome

  • ORIGINAL PAPER
  • Published:
Clinical Research in Cardiology Aims and scope Submit manuscript

Summary

Objectives

Though cardiac troponin-T may be positive in hypertrophic and dilative cardiomyopathy, it is not known how often troponin-T is positive in left ventricular hypertrabeculation/ noncompaction (LVHT), an unclassified cardiomyopathy. This retrospective study aimed to assess how often troponin-T is positive in LVHT, is associated with elevated CK, is attributable to cardiac or extra-cardiac causes, in particular neuromuscular disorders (NMDs), or if it is a predictor of poor survival.

Results

Among 100 patients, detected over a period of 11 years, troponin-T was determined at least once in 71 (71%) of them. Troponin-T was determined once in 36 patients, twice in 8 cases, three times in 11 patients, and more than three times in 16 cases. Troponin- T was positive at least once in 12 patients (17%). Forty-five of the 71 patients suffered from a NMD (63%). Troponin-T positivity was associated with elevated CK in 6 cases. Troponin-T-positivity was attributable to acute myocardial ischemia in a single case, to chronic renal failure in 5 cases, to dilative cardiomyopathy in 4 cases, to atrial fibrillation in 3 cases, to heart failure in 4 cases, and to NMD in 10 cases. Troponin-T positivity in LVHT patients with NMD was assumed to be due to cardiac involvement in the disease. Among the 22 patients who died during the observational period troponin was determined in 16 and was positive in 4 (25%).

Conclusions

Troponin-T is positive in 17% of the patients with LVHT. Most of these patients suffer from a NMD. Troponin-T positivity in LVHT predicts the presence of NMD and poor survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Hamilton JS, Sharpe PC (2005) Two cases of inflammatory muscle disease presenting with raised serum concentrations of troponin-T. J Clin Pathol 58:1323–1324

    Article  PubMed  CAS  Google Scholar 

  2. Erlacher P, Lercher A, Falkensammer J, Nassonov EL, Samsonov MI, Shtutman VZ, Puschendorf B, Mair J (2001) Cardiac troponin and betatype myosin heavy chain concentrations in patients with polymyositis or dermatomyositis. Clin Chim Acta 306:27–33

    Article  PubMed  CAS  Google Scholar 

  3. Kobayashi S, Tanaka M, Tamura N, Hashimoto H, Hirose S (1992) Serum cardiac troponin-T in polymyositis/ dermatomyositis. Lancet 340:726

    Article  PubMed  CAS  Google Scholar 

  4. Schwarzmeier JD, Hamwi A, Preisel M, Resl C, Preusser M, Sluga E, Horcher E, Shehata MM (2005) Positive troponin-T without cardiac involvement in inclusion body myositis. Hum Pathol 36:917–921

    Article  PubMed  CAS  Google Scholar 

  5. White GH, Tideman PA (2001) Increased troponin-T in a patient with dermatomyositis. Clin Chem 47:1130– 1131

    PubMed  CAS  Google Scholar 

  6. Jeremias A, Gibson CM (2005) Narrative review: alternative causes for elevated cardiac troponin levels when acute coronary syndromes are excluded. Ann Intern Med 142:786–791

    PubMed  Google Scholar 

  7. Higgins JP, Higgins JA (2003) Elevation of cardiac troponin I indicates more than myocardial ischemia. Clin Invest Med 26:133–147

    PubMed  CAS  Google Scholar 

  8. Jossi S, Gordon SL, Legge MA, Armstrong GP (2006) All troponins are not created equal. Intern Med J 36:325–327

    Article  PubMed  CAS  Google Scholar 

  9. Athanasiadis A, Vogelsberg H, Hauer B, Meinhardt G, Hill S, Sechtem U (2006) Transient left ventricular dysfunction with apical ballooning (tako-tsubo cardiomyopathy) in Germany. Clin Res Cardiol 95:321–328

    Article  PubMed  Google Scholar 

  10. Sato Y, Taniguchi R, Yamada T, Matsumori A (2003) Measurements of serum cardiac troponin-T in patients with heart failure. Am Heart J 145:e18

    Article  PubMed  Google Scholar 

  11. Mahajan N, Mehta Y, Rose M, Shani J, Lichstein E (2005) Elevated troponin level is not synonymous with myocardial infarction. Int J Cardiol 111:442–449

    Article  PubMed  Google Scholar 

  12. Sutidze M, Sulakvelidze M, Kochiashvili D, Labadze D, Rukhadze I (2006) Creatine kinase mb, cardiac troponin-T and cardiac troponin-I as the markers of rhabdomyolysis in chronic hemodialysis patients. Georgian Med News 132:68–71

    PubMed  Google Scholar 

  13. Hoogerwaard EM, Schouten Y, van der Kooi AJ, Gorgels JP, de Visser M, Sanders GT (2001) Troponin-T and troponin-I in carriers of Duchenne and Becker muscular dystrophy with cardiac involvement. Clin Chem 47:962–693

    PubMed  CAS  Google Scholar 

  14. Prellwitz W, Hafner G, Rupprecht HJ, Meyer J (1996) Diagnostic and differential diagnostic value of troponins, Med Klin (Munich) 91:336–342

    CAS  Google Scholar 

  15. Messner B, Baum H, Fischer P, Quasthoff S, Neumeier D (2000) Expression of messenger RNA of the cardiac isoforms of troponin-T and I in myopathic skeletal muscle. Am J Clin Pathol 114:544–549

    PubMed  CAS  Google Scholar 

  16. Hammerer-Lercher A, Erlacher P, Bittner R, Korinthenberg R, Skladal D, Sorichter S, Sperl W, Puschendorf B, Mair J (2001) Clinical and experimental results on cardiac troponin expression in Duchenne muscular dystrophy. Clin Chem 47:451–458

    PubMed  CAS  Google Scholar 

  17. Ricchiuti V, Apple FS (1999) RNA expression of cardiac troponin-T isoforms in diseased human skeletal muscle. Clin Chem 45:2129–2135

    PubMed  CAS  Google Scholar 

  18. Mair J (1997) Cardiac troponin-I and troponin-T: are enzymes still relevant as cardiac markers? Clin Chim Acta 257:99–115

    Article  PubMed  CAS  Google Scholar 

  19. Tung P, Kopelnik A, Banki N, Ong K, Ko N, Lawton MT, Gress D, Drew B, Foster E, ParmleyW, Zaroff J (2004) Predictors of neurocardiogenic injury after subarachnoid hemorrhage. Stroke 35:548–551

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Krankenanstalt Rudolfstiftung, 20, 1180, Vienna, Austria

    Josef Finsterer MD PhD

  2. Second Medical Department, Vienna, Austria

    Claudia Stöllberger MD

  3. Central Laboratory, Krankenanstalt Rudolfstiftung, Vienna, Austria

    Walter Krugluger MD

Authors
  1. Josef Finsterer MD PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudia Stöllberger MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Walter Krugluger MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Josef Finsterer MD PhD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Finsterer, J., Stöllberger, C. & Krugluger, W. Positive troponin-T in noncompaction is associated with neuromuscular disorders and poor outcome. Clin Res Cardiol 96, 109–113 (2007). https://doi.org/10.1007/s00392-006-0467-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00392-006-0467-7

Key words

Search

Navigation