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Inflammation, ECG changes and pericardial effusion

Whom to biopsy in suspected myocarditis?

  • CRITICAL PERSPECTIVE
  • Published:
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Summary

The role of endomyocardial biopsies in patients with clinically suspected acute myocarditis, myocarditis in the past, and dilated cardiomyopathy is discussed controversially. In fact, it is still under discussion whether information obtained from endomyocardial biopsies is relevant for further clinical decisions. Therefore this Critical Perspective will deal with the question, which patient should undergo endomyocardial biopsy investigations for an etiopathogenic differentiation of the disease and for the possible choice of immunomodulatory treatment strategies.

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Abbreviations

BICC-Trial:

Betaferon® in Chronic Viral Cardiomyopathy

CK:

Creatinine kinase

DCM:

Dilated cardiomyopathy

DCMi:

Inflammatory cardiomyopathy

ECG:

Electrocardiogram

EMB:

Endomyocardial biopsy

LV:

Left ventricle

PCR:

Polymerase chain reaction

TIMP:

Tissue inhibitors of matrix metalloproteinases

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Acknowledgement

This work was supported by the Deutsche Forschungsgemeinschaft (Sonderforschungsbereich Transregio 19).

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Pauschinger, M., Noutsias, M., Lassner, D. et al. Inflammation, ECG changes and pericardial effusion. Clin Res Cardiol 95, 569–583 (2006). https://doi.org/10.1007/s00392-006-0427-2

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