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Release pattern of N–terminal pro B–type natriuretic peptide (NT–proBNP) in acute coronary syndromes

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Summary

Background

Recently it has been found that BNP and NT–proBNP provide independent prognostic information in patients with acute coronary syndromes (ACS). However, little data are available on the time course of NT–proBNP levels in relation to onset of symptoms.

Methods and results

We included 765 patients (236 females, aged 64 ± 11 years) with an ACS (STEMI 42%, NSTEMI 41%, UAP 17%), who were referred for coronary angiography. NT–proBNP was assessed on admission and the next day. NT–proBNP values were related to the time duration from onset of symptoms until blood drawing with lowest values within 3 h and highest values 24–36 h after onset of symptoms (147 (64–436) pg/ml and 1099 (293–3795) pg/ml, respectively, p < 0.001). Highest values for NT–proBNP on admission were found in patients with NSTEMI compared to patients with STEMI and UAP (912 (310–2258) pg/ml) vs 262 (85–1282) pg/ml) vs 182 (74– 410) pg/ml; p < 0.001), but no difference was present between STEMI and NSTEMI the day after admission (1325 (532–2974) pg/ ml vs 1169 (555–3413) pg/ml; p = 0.676). In contrast NT–proBNP values remained unchanged in UAP (182 (74–410) pg/ml) vs 171 (53–474) pg/ml).

Conclusion

The time interval from onset of symptoms to first blood collection is an important determinant for NT–proBNP values on admission in patients with an ACS and needs to be considered in clinical practice.

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Authors and Affiliations

  1. Kerckhoff Heart Center, Departement of Cardiology, Benekestraße 2–8, 61231, Bad Nauheim, Germany

    Michael Weber MD, Christian Kleine, Eva Keil, Matthias Rau, Alexander Berkowitsch, Albrecht Elsaesser, Vesselin Mitrovic & Christian Hamm

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  1. Michael Weber MD
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  2. Christian Kleine
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  3. Eva Keil
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  4. Matthias Rau
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Correspondence to Michael Weber MD.

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Weber, M., Kleine, C., Keil, E. et al. Release pattern of N–terminal pro B–type natriuretic peptide (NT–proBNP) in acute coronary syndromes. Clin Res Cardiol 95, 270–280 (2006). https://doi.org/10.1007/s00392-006-0375-x

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  • DOI: https://doi.org/10.1007/s00392-006-0375-x

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