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Stellenwert der Gated-SPECT-Myokardperfusionsszintigraphie zur Beurteilung des individuellen kardialen Risikos

Value of gated SPECT myocardial perfusion imaging for individual cardiac risk assessment

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Summary

Myocardial perfusion imaging enables not only accurate diagnosis of disease but also entails prognostic value. Myocardial perfusion SPECT contributes to assessment of future cardiac events independently of other clinical parameters. A normal stress myocardial perfusion scan is associated with a favorable prognosis independent of history, symptoms, and exercise electrocardiography test variables. Cardiac risk and benefit from invasive therapeutic strategies increase in relation to the severity of the abnormality of perfusion and function assessed by gated myocardial perfusion SPECT. Thus, stress myocardial perfusion imaging may serve as a gatekeeper for referral to coronary angiography enabling effective risk stratification in patients with suspected or documented coronary artery disease.

Zusammenfassung

Die Aussagen der Myokardperfusions-SPECT enthalten ergänzend zur diagnostischen Wertigkeit auch eine prognostische Information. Sie gestatten eine Abschätzung der zukünftigen kardialen Ereignisrate unabhängig von weiteren klinischen Parametern. Ein Normalbefund in der Belastungsmyokardperfusions-SPECT ist unabhängig von anamnestischen, klinischen und ergometrischen Daten mit einer guten Prognose verbunden. Mit zunehmendem Ausmaß von Perfusionsdefekten und Funktionsstörungen in der herzphasengetriggert-akquirierten Myokardperfusions-SPECT (Gated-SPECT) steigt das Risiko zukünftiger kardialer Ereignisse und somit der Zugewinn durch eine invasive Therapiestrategie an. Mit der Gated-SPECT als „Gatekeeper“ für die Überweisung zur Koronarangiographie gelingt eine effiziente Risikostratifizierung von Patienten mit vermuteter oder chronischer koronarer Herzerkrankung.

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References

  1. Bateman TM (1997) Clinical relevance of a normal myocardial perfusion scintigraphic study. J Nucl Cardiol 4:172–173

    CAS  PubMed  Google Scholar 

  2. Berman DS, Kang X, Hayes SW, Friedman JD, Cohen I, Abidov A, Shaw LJ, Amanullah AM, Germano G, Hachamovitch R (2003) Adenosine myocardial perfusion single-photon emission computed tomography in women compared with men. Impact of diabetes mellitus on incremental prognostic value and effect on patient management. J Am Coll Cardiol 41:1125–1133

    PubMed  Google Scholar 

  3. Brown KA, Heller GV, Landin RS, Shaw LJ, Beller GA, Pasquale MJ, Haber SB (1999) Early dipyridamole (99m)Tc-sestamibi single photon emission computed tomographic imaging 2 to 4 days after acute myocardial infarction predicts in-hospital and postdischarge cardiac events: comparison with submaximal exercise imaging. Circulation 100:2060–2066

    CAS  PubMed  Google Scholar 

  4. De Lorenzo A, Lima RS, Siqueira-Filho AG, Pantoja MR (2002) Prevalence and prognostic value of perfusion defects detected by stress technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography in asymptomatic patients with diabetes mellitus and no known coronary artery disease. Am J Cardiol 90:827–832

    Article  Google Scholar 

  5. Giri S, Shaw LJ, Murthy DR, Travin MI, Miller DD, Hachamovitch R, Borges-Neto S, Berman DS, Waters DD, Heller GV (2002) Impact of diabetes on the risk stratification using stress single-photon emission computed tomography myocardial perfusion imaging in patients with symptoms suggestive of coronary artery disease. Circulation 105:32–40

    Article  PubMed  Google Scholar 

  6. Hachamovitch R, Berman DS, Shaw LJ, Kiat H, Cohen I, Cabico JA, Friedman J, Diamond GA (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97:535–543

    CAS  PubMed  Google Scholar 

  7. Hachamovitch R, Hayes SW, Friedman JD, Cohen I, Berman DS (2003) Comparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography. Circulation 107:2900–2906

    Article  PubMed  Google Scholar 

  8. Hashimoto J, Suzuki T, Nakahara T, Kosuda S, Kubo A (2003) Preoperative risk stratification using stress myocardial perfusion scintigraphy with electrocardiographic gating. J Nucl Med 44:385–390

    PubMed  Google Scholar 

  9. Iskander S, Iskandrian AE (1998) Risk assessment using single-photon emission computed tomographic technetium-99m sestamibi imaging. J Am Coll Cardiol 32:57–62

    Article  CAS  PubMed  Google Scholar 

  10. Lima RSL, Watson DD, Goode AR, Siadaty MS, Ragosta M, Beller GA, Samady H (2003) Incremental value of combined perfusion and function over perfusion alone by gated SPECT myocardial perfusion imaging for detection of severe three-vessel coronary artery disease. J Am Coll Cardiol 42:64–70

    PubMed  Google Scholar 

  11. Nowak B (2004) Nuklearkardiologische Methoden zur Prognosebeurteilung und Risikostratifizierung bei koronarer Herzkrankheit. Nuklearmediziner 27:176–185

    Google Scholar 

  12. Schäfers M (2002) Methoden und klinische Anwendung der Nuklearkardiologie: Positionsbericht. Nuklearmedizin 41:3–13

    PubMed  Google Scholar 

  13. Sharir T, Germano G, Kavanagh PB, Lai S, Cohen I, Lewin HC, Friedman JD, Zellweger MJ, Berman DS (1999) Incremental prognostic value of poststress left ventricular ejection fraction and volume by gated myocardial perfusion single photon emission computed tomography. Circulation 100:1035–1042

    CAS  PubMed  Google Scholar 

  14. Sharir T, Germano G, Kang X, Lewin HC, Miranda R, Cohen I, Agafitei RD, Friedman JD, Berman DS (2001) Prediction of myocardial infarction versus cardiac death by gated myocardial perfusion SPECT: risk stratification by the amount of stress-induced ischemia and the poststress ejection fraction. J Nucl Med 42:831–837

    CAS  PubMed  Google Scholar 

  15. Travin MI, Heller GV, Johnson LL, Katten D, Ahlberg AW, Isasi CR, Kaplan RC, Taub CC, Demus D (2004) The prognostic value of ECG-gated SPECT imaging in patients undergoing stress Tc-99m sestamibi myocardial perfusion imaging. J Nucl Cardiol 11:253–262

    PubMed  Google Scholar 

  16. Vanzetto G, Ormezzano O, Fagret D, Comet M, Denis B, Machecourt J (1999) Long-term additive prognostic value of thallium-201 myocardial perfusion imaging over clinical and exercise stress test in low to intermediate risk patients: study in 1137 patients with 6-year follow-up. Circulation 100:1521–1527

    CAS  PubMed  Google Scholar 

  17. Zellweger MJ, Hachamovitch R, Kang X, Hayes SW, Friedman JD, Germano G, Pfisterer ME, Berman DS (2004) Prognostic relevance of symptoms versus objective evidence of coronary artery disease in diabetic patients. Eur Heart J 25:543–550

    PubMed  Google Scholar 

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Nowak, B. Stellenwert der Gated-SPECT-Myokardperfusionsszintigraphie zur Beurteilung des individuellen kardialen Risikos. ZS Kardiologie 94 (Suppl 4), iv81–iv84 (2005). https://doi.org/10.1007/s00392-005-1417-5

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