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Gegenseitige Beeinflussung von Insomnie im Alter und assoziierten Erkrankungen

Kognitive, behaviorale und neurobiologische Aspekte

Interaction of insomnia in old age and associated diseases

Cognitive, behavioral and neurobiological aspects

  • 42 Accesses

Zusammenfassung

Die Prävalenz von Insomnien ist im Alter besonders hoch. Oft treten Ein- und Durchschlafstörungen sowie hieraus resultierende Beeinträchtigungen wie Stimmungsschwankungen oder Konzentrationsschwierigkeiten im Zusammenspiel mit anderen Erkrankungen wie beispielsweise Depressionen auf. Dieser Beitrag zielt darauf ab, die Rolle der Insomnie im Kontext häufiger Komorbiditäten im Alter zu beleuchten. Der Schwerpunkt liegt auf der Identifizierung von Verknüpfungspunkten zwischen Insomnien und damit assoziierten Erkrankungen auf neurobiologischer Ebene. Es werden jedoch auch mögliche Abgrenzungsmerkmale benannt und Ausführungen zu kognitiv-behavioralen Aspekten und integrativen Theorien wie der „Hyperarousal“-Theorie eingeflochten. Um einen Ausblick auf zukünftige Forschungsansätze zu ermöglichen, wird in einem weiteren Abschnitt die sog. UK Biobank als vielversprechende Ressource portraitiert. Abschließend finden eine kritische Einordung der vorangegangenen Ausführungen sowie die Ableitung praktischer Implikationen für die Behandlung von älteren Patienten mit Insomnie statt.

Abstract

The prevalence of insomnia is particularly high in old age. Sleep disturbances and impaired daytime functioning reflected in mood swings and concentration difficulties are often accompanied by other mental disorders such as depression. The objective of this article is to shed light on the role of insomnia in the context of frequent comorbidities in middle and old age. The focus is on the identification of linkage points between insomnia and associated diseases on a neurobiological level; however, possible distinguishing features are also named and deliberations on cognitive behavioral aspects and integrative theories, such as the hyperarousal theory are discussed. In order to provide an outlook for future research opportunities, the UK Biobank is presented as a promising resource of long-term data. Finally, the contents of the preceding deliberations are critically reflected and practical implications for the treatment of older patients with insomnia are derived.

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Danksagung

Die Autoren danken Frau Natasza Walter (MSc) für das Einbringen ihrer sprachlichen Expertise bei der internen Revision des englischen Abstracts.

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Correspondence to J. E. Schiel MSc.

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Interessenkonflikt

J. E. Schiel und K. Spiegelhalder geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden keine Studien an Menschen oder Tieren durchgeführt. Zitierte Studien unter Beteiligung des Autors K. Spiegelhalder wurden mit Zustimmung der zuständigen Ethikkommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt.

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Schiel, J.E., Spiegelhalder, K. Gegenseitige Beeinflussung von Insomnie im Alter und assoziierten Erkrankungen. Z Gerontol Geriat (2020). https://doi.org/10.1007/s00391-020-01694-6

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Schlüsselwörter

  • Gehirnmetabolismusstörungen
  • Funktionelles Neuroimaging
  • Arousal
  • Kognitive Funktionen
  • UK Biobank

Keywords

  • Brain disorders, metabolic
  • Functional neuroimaging
  • Arousal
  • Cognitive function
  • UK Biobank