Skip to main content
Log in

Präventionsstrategien gegen Demenz

Preventive strategies for dementia

  • Beiträge zum Themenschwerpunkt
  • Published:
Zeitschrift für Gerontologie und Geriatrie Aims and scope Submit manuscript

An Erratum to this article was published on 17 March 2017

Zusammenfassung

Im Kontext des demografisch bedingten Anstiegs der Prävalenz von Demenzerkrankungen bei gleichzeitig fehlenden kausalen pharmakologischen Therapien gewinnen Präventionskonzepte zunehmend an Bedeutung. Durch gezielte Reduzierung von Risikofaktoren und Maßnahmen zur Induktion von Neuroplastizität kann erfolgreiches Altern unterstützt werden. Der Beitrag fasst die aktuellen Entwicklungen auf dem Gebiet der Demenzprävention durch Modifikation von Lebensstilfaktoren zusammen. Den Schwerpunkt bildet die Betrachtung des Einflusses von kognitiver und körperlicher Aktivität auf die Neuroprotektion. Ein vielversprechender Ansatz vereint die beiden Aktivitäten in einem Tanztraining. Auf die Notwendigkeit weiterer Studien, die den hohen Anforderungen einer randomisierten klinischen Studie gerecht werden, wird nachdrücklich hingewiesen.

Abstract

In the context of the demographically induced increase in the prevalence of dementia and the simultaneous lack of causal pharmacological therapies, preventive approaches are gaining in importance. By reducing risk factors and with measures which induce neuroplasticity successful aging can be supported. This article summarizes the current developments in preventing dementia by modification of life style factors. The main focus lies on the impact of cognitive and physical activity on neuroprotection. A promising approach combines both activities within a dance training program. Further studies that meet the demanding criteria of a randomized clinical trial are urgently needed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Alzheimer’s Disease International (2014) World alzheimer report 2014. ADI, London

    Google Scholar 

  2. Ball LJ, Birg SJ (2002) Preventions of brain aging and dementia. Clin Geriatr Med 18:485–503

    Article  PubMed  Google Scholar 

  3. Bamadis PD, Vivas AB, Styliadis C et al (2014) A review of physical and cognitive interventions in aging. Neurosci Biobehav Rev 44:206–220

    Article  Google Scholar 

  4. Barnes DE, Yaffe K (2011) The projected impact of risk factor reduction on alzheimer’s disease prevalence. Lancet Neurol 10:819–828

    Article  PubMed  PubMed Central  Google Scholar 

  5. Boyke J, Driemeyer J, Gaser C et al (2008) Training-induced brain structure changes in the elderly. J Neurosci 28:7031–7035

    Article  CAS  PubMed  Google Scholar 

  6. Cassilhas RC, Viana VA, Grassmann V et al (2007) The impact of resistance exercise on the cognitive function of the elderly. Med Sci Sports Exerc 39(8):1401–1407

    Article  PubMed  Google Scholar 

  7. Cheng Y, Wu W, Feng W et al (2012) The effects of multi-domain versus single-domain cognitive training in non-demented older people: a randomized controlled trial. BMC Med 27:10–30

    Google Scholar 

  8. Colcombe SJ, Erickson KI, Raz N et al (2003) Aerobic fitness reduces brain tissue loss in aging humans. J Gerontol Med Sci 58 A(2):176–180

    Article  Google Scholar 

  9. Craik FIM (1983) On the transfer of information from temporary to permanent memory. Philos Trans Royal Soc London Ser B 302:341–359

  10. Craik FM, Byrd M (1982) Aging and cognitive deficits: the role of attentional resources. In: Craik FIM, Trehub SE (Hrsg) Aging and cognitive processes. Plenum Press, New York, S 191–211

    Chapter  Google Scholar 

  11. Cummings JL, Morstoff T, Zhong K (2014) Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther 6:37–42

    Article  PubMed  PubMed Central  Google Scholar 

  12. Deuschl G, Maier W et al (2009) S3 Leitlinie Demenzen. In: Diagnose- und Behandlungsleitlinie Demenz. Deutsche Gesellschaft für Neurologie, Berlin

    Google Scholar 

  13. Echávarri C, Aalten P, Uyling HBM et al (2011) Atrophy in the parahippocampal gyrus as an early biomarker of Alzheimer’s disease. Brain Struct Funct. doi:10.1007/s00429-010-0283-8

    PubMed  Google Scholar 

  14. Erickson KI, Prakash RS, Voss MW et al (2009) Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 19(10):1030–1039

    Article  PubMed  PubMed Central  Google Scholar 

  15. Erickson KI, Voss MW, Prakash RS et al (2011) Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 108(7):3017–3022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Förstl H, Kurz A, Hartmann A (2011) Alzheimer-Demenz. In: Först H (Eds.) Demenzen in Theorie und Praxis (47–72). Berlin: Springer-Verlag

  17. Fratiglioni L, Paillard-Borg S, Winblad B (2004) An active and socially integrated lifestyle in late life might protect against dementia. Lancet Neurol 3(6):343–353

    Article  PubMed  Google Scholar 

  18. Good CD, Johnsrude IS, Ashburner J et al (2001) A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage 14:21–36

    Article  CAS  PubMed  Google Scholar 

  19. Gregory SM, Parker B, Thompson PD (2012) Physical activity, cognitive function, and brain health: what is the role of exercise training in the prevention of dementia? Brain Sci 2(4):684–708

    Article  PubMed  PubMed Central  Google Scholar 

  20. Hamer M, Chida Y (2009) Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence. Psychol Med 39(1):3–11

    Article  CAS  PubMed  Google Scholar 

  21. Hedden T, Gabrieli JD (2004) Insights into the ageing mind: a view from cognitive neuroscience. Nat Rev Neurosci 5(2):87–96

    Article  CAS  PubMed  Google Scholar 

  22. Kattenstroth JC, Kalisch T, Holt S et al (2013) Six months of dance intervention enhances postural, sensorimotor, and cognitive performance in elderly without affecting cardiorespiratory functions. Front Aging Neurosci 5:1–16

    Article  Google Scholar 

  23. Kempermann G, Fabel K, Ehninger D et al (2010) Why and how physical activity promotes experience-induced brain plasticity. Front Neurosci 4:189

    Article  PubMed  PubMed Central  Google Scholar 

  24. Kimura K, Obuchi S, Arai T et al (2010) The influence of short-term strength training on health-related quality of life and executive cognitive function. J Physiol Anthropol 29(3):95–101

    Article  PubMed  Google Scholar 

  25. Kivipelto M, Mangialasche F (2014) Alzheimer disease: to what extent can Alzheimer disease be prevented? Nat Rev Neurol 10:552–553

    Article  CAS  PubMed  Google Scholar 

  26. Kivipelto M, Solomon A, Ahtiluoto S et al (2013) The finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimers Dement 9:657–665

    Article  PubMed  Google Scholar 

  27. Klusmann V, Evers A, Schwarzer R et al (2010) Complex mental and physical activity in older women and cognitive performance: a 6-month randomized controlled trial. J Gerontol A Biol Sci Med Sci 65(6):680–688

    Article  PubMed  Google Scholar 

  28. Larson EB, Wang L, Bowen JD et al (2006) Exercise is associated with reduced risk for incident dementia among persons 65 years and older. Ann Intern Med 144(2):73–81

    Article  PubMed  Google Scholar 

  29. Li SC, Schmiedek F, Huxhold O et al (2008) Working memory plasticity in old age: practice gain, transfer, and maintenance. Psychol Aging 23(4):731–742

    Article  PubMed  Google Scholar 

  30. Liu-Ambrose T, Nagamatsu LS, Graf P et al (2010) Resistance training and executive functions: a 12-month randomized controlled trial. Arch Intern Med 170(2):170–178

    Article  PubMed  PubMed Central  Google Scholar 

  31. Miller DI, Taler V, Davidson PS, Messier C (2012) Measuring the impact of exercise on cognitive aging: methodological issues. Neurobiol Aging 33(3):622–643

    Article  PubMed  Google Scholar 

  32. Mitchell AJ, Shiri-Feshki M (2009) Rate of progression of mild cognitive impairment to dementia meta-analysis of 41 robust inception cohort studies. Acta Psychiatr Scand 119:252–265

    Article  CAS  PubMed  Google Scholar 

  33. Mowszowski L, Batchelor J, Naismith SL (2010) Early intervention for cognitive decline: can cognitive training be used as a selective prevention technique? Int Psychogeriatr 22(4):537–548

    Article  PubMed  Google Scholar 

  34. Müller P, Rehfeld K, Lüders A et al (2016) Effekte eines Tanz- und eines Gesundheitssporttrainings auf die graue Hirnsubstanz gesunder Senioren. Sportwissenschaft 46(3):213–222. doi:10.1007/s12662-016-0411-6

    Article  Google Scholar 

  35. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C (2014) Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data. Lancet Neurol 13:788–794

    Article  PubMed  Google Scholar 

  36. Owen AM, Hampshire A, Grahn et al (2010) UKPMC funders group putting brain training to the test. Burns 465(7299):775–778

    CAS  Google Scholar 

  37. Papp KV, Walsh SJ, Snyder PJ (2009) Immediate and delayed effects of cognitive interventions in healthy elderly: a review of current literature and future directions. Alzheimers Dement 5(1):50–60

  38. Petersen RC, Smith GE, Waring SC et al (1999) Mild cognitive im pairment: clinical characterization and outcome. Arch Neurol 56(3):303–308

    Article  CAS  PubMed  Google Scholar 

  39. Peverill M, McLaughlin KA, Finn AS, Sheridan MA (2016) Working memory filtering continues to develop into late adolescence. Dev Cogn Neurosci 18:78–88

    Article  PubMed  PubMed Central  Google Scholar 

  40. Raz N, Lindenberger U, Rodrigue KM et al (2005) Regional brain changes in aging healthy adults: general trends, individual differences and modifiers. Cereb Cortex 15(11):1676–1689

    Article  PubMed  Google Scholar 

  41. Rehfeld K, Hökelmann A, Lehmann W, Blaser P (2015) Auswirkungen einer Tanz-und Kraft-Ausdauer-Intervention auf kognitive Fähigkeiten älterer Menschen. Z Neuropsychol 25:99–108

    Article  Google Scholar 

  42. Rubinstein E, Duggan C, Van Landingham B, Thompson D, Warburton W (2015) A call to action: the global response to dementia through policy innovation. Report of the WISH dementia forum 2015. http://mhinnovation.net/sites/default/files/downloads/resource/WISH_Dementia_Forum_Report_08.01.15_WEB.pdf. Zugegriffen: 14.12.2016

  43. Schmicker M, Schwefel M, Vellage AK, Müller NG (2016) Training of attentional filtering, but not of memory storage, enhances working memory efficiency by strengthening the neuronal gatekeeper network. J Cogn Neurosci 28(4):636–642

    Article  PubMed  Google Scholar 

  44. Sehm B, Taubert M, Conde V et al (2014) Structural brain plasticity in Parkinson’s disease induced by balance training. Neurobiol Aging 35:232–239

    Article  PubMed  Google Scholar 

  45. Simone PM, Baylis GC (1997) The role of attention in a spatial memory task in Alzheimer disease patients. Alzheimer Dis Assoc Disord 11(3):140–152

    Article  CAS  PubMed  Google Scholar 

  46. Sperling RA, Aisen PS et al (2011) Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 7:280–292

    Article  PubMed  PubMed Central  Google Scholar 

  47. Steiner B, Witte V, Flöel A (2011) Lebensstil und Kognition. Nervenarzt 82:1566–1577

    Article  CAS  PubMed  Google Scholar 

  48. Stern Y (2009) Cognitive reserve. Neuropsychologia 47:2015–2028

    Article  PubMed  PubMed Central  Google Scholar 

  49. Stine-Morrow EA, Parisi JM, Morrow DG, Park DC (2008) The effects of an engaged lifestyle on cognitive vitality: a field experiment. Psychol Aging 23(4):778–786

    Article  PubMed  PubMed Central  Google Scholar 

  50. Tesky V, Thiel C, Banzer W, Pantel J (2011) Effects of a group program to increase cognitive performance through cognitively stimulating Ieisure activities in healthy older subject. GeroPsych (Bern) 24(2):83–92

    Article  Google Scholar 

  51. Valenzuela M, Sachdev P (2009) Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up. Am J Geriatr Psychiatry 17(3):179–187

    Article  PubMed  Google Scholar 

  52. Valenzuela MJ, Sachdev P, Wen W, Chen X, Brodaty H (2008) Lifespan mental activity predicts diminished rate of hippocampal atrophy. PLOS ONE 3(7):e2598

    Article  PubMed  PubMed Central  Google Scholar 

  53. Vemuri PI, Lesnick TG, Przybelski SA et al (2012) Effect of lifestyle activities on Alzheimer disease biomarkers and cognition. Ann Neurol 72(5):730–738

    Article  PubMed  PubMed Central  Google Scholar 

  54. Verghese J, Lipton RB, Katz MJ (2003) Leisure activities and the risk of dementia in the elderly. New Engl J Med 348(25):2508–2016

    Article  PubMed  Google Scholar 

  55. Weltgesundheitsorganisation (WHO) (2010) World Health Report 2010: Global Recommendations on Physical Activity for Health. WHO, Switzerland

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Patrick Müller M.A..

Ethics declarations

Interessenkonflikt

P. Müller, M. Schmicker und N.G. Müller geben an, dass kein Interessenkonflikt besteht.

Alle im vorliegenden Manuskript beschriebenen Untersuchungen am Menschen wurden mit Zustimmung der zuständigen Ethikkommission, im Einklang mit nationalem Recht sowie gemäß der Deklaration von Helsinki von 1975 (in der aktuellen, überarbeiteten Fassung) durchgeführt. Von allen beteiligten Patienten liegt eine Einverständniserklärung vor.

The supplement containing this article is not sponsored by industry.

Additional information

Ein Erratum zu diesem Beitrag ist unter http://dx.doi.org/10.1007/s00391-017-1218-2 zu finden.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Müller, P., Schmicker, M. & Müller, N.G. Präventionsstrategien gegen Demenz. Z Gerontol Geriat 50 (Suppl 2), 89–95 (2017). https://doi.org/10.1007/s00391-017-1202-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00391-017-1202-x

Schlüsselwörter

Keywords

Navigation