Acknowledgments
We gratefully acknowledge the Bundesministerium für Bildung und Forschung for supporting our project “ClimAge”.
Compliance with ethical guidelines
Conflict of interest. C. Degen, S.E. Kettner, H. Fischer, J. Lohse, J. Funke, C. Schwieren, T. Goeschl, and J. Schröder state that there are no conflicts of interest. All studies on humans described in the present manuscript were carried out with the approval of the responsible ethics committee and in accordance with national law and the Helsinki Declaration of 1975 (in its current, revised form). Informed consent was obtained from all patients included in studies.